Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SANR_RS09370 Genome accession   NC_022239
Coordinates   1926114..1926854 (-) Length   246 a.a.
NCBI ID   WP_003038927.1    Uniprot ID   -
Organism   Streptococcus anginosus C238     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1909425..1993501 1926114..1926854 within 0


Gene organization within MGE regions


Location: 1909425..1993501
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SANR_RS09310 (SANR_1806) - 1910009..1910875 (-) 867 WP_003037699.1 sensor histidine kinase -
  SANR_RS09315 (SANR_1807) - 1910878..1911555 (-) 678 WP_003037807.1 response regulator transcription factor -
  SANR_RS09320 (SANR_1808) - 1911736..1913175 (-) 1440 WP_003037795.1 6-phospho-beta-glucosidase -
  SANR_RS09325 (SANR_1809) lctO 1913430..1914566 (-) 1137 WP_003037688.1 L-lactate oxidase -
  SANR_RS09330 (SANR_1810) spxB 1914826..1916631 (-) 1806 WP_003037777.1 pyruvate oxidase -
  SANR_RS09335 (SANR_1811) ldcB 1916887..1919697 (-) 2811 WP_003037692.1 LD-carboxypeptidase LdcB/DacB -
  SANR_RS09340 (SANR_1812) - 1919732..1920382 (-) 651 WP_020999824.1 DUF6287 domain-containing protein -
  SANR_RS09345 (SANR_1813) - 1920524..1921063 (-) 540 WP_003037787.1 SH3 domain-containing protein -
  SANR_RS09350 (SANR_1814) - 1921203..1923317 (-) 2115 WP_020999825.1 GBS Bsp-like repeat-containing protein -
  SANR_RS09355 (SANR_1815) - 1923726..1924550 (-) 825 WP_003037768.1 sensor histidine kinase -
  SANR_RS09360 (SANR_1816) - 1924670..1925605 (-) 936 WP_020999450.1 IS30 family transposase -
  SANR_RS11655 - 1925682..1926092 (-) 411 WP_003038906.1 hypothetical protein -
  SANR_RS09370 (SANR_1817) comE/blpR 1926114..1926854 (-) 741 WP_003038927.1 response regulator transcription factor Regulator
  SANR_RS09375 (SANR_1818) - 1926986..1927624 (-) 639 WP_003038917.1 SGNH/GDSL hydrolase family protein -
  SANR_RS09380 (SANR_1819) - 1927624..1928454 (-) 831 WP_003038886.1 Cof-type HAD-IIB family hydrolase -
  SANR_RS09385 (SANR_1820) - 1928818..1929963 (+) 1146 WP_003038882.1 cobalamin-independent methionine synthase II family protein -
  SANR_RS09390 (SANR_1821) - 1930463..1930849 (-) 387 WP_003038936.1 VOC family protein -
  SANR_RS09395 (SANR_1822) - 1930839..1932278 (-) 1440 WP_020999826.1 glycoside hydrolase family 1 protein -
  SANR_RS09400 (SANR_1823) - 1932390..1933259 (+) 870 WP_003038853.1 AraC family transcriptional regulator -
  SANR_RS09405 (SANR_1824) - 1933274..1933783 (+) 510 WP_020999827.1 HXXEE domain-containing protein -
  SANR_RS09410 (SANR_1825) - 1933863..1935128 (-) 1266 WP_003038912.1 CapA family protein -
  SANR_RS09415 (SANR_1826) - 1935288..1937210 (-) 1923 WP_003038869.1 beta-glucoside-specific PTS transporter subunit IIABC -
  SANR_RS09420 (SANR_1827) - 1937529..1937852 (-) 324 WP_003038930.1 PTS lactose/cellobiose transporter subunit IIA -
  SANR_RS09425 (SANR_1828) - 1937862..1938182 (-) 321 WP_003038890.1 PTS sugar transporter subunit IIB -
  SANR_RS09430 (SANR_1829) - 1938217..1939113 (-) 897 WP_020999828.1 phosphonomutase-like protein -
  SANR_RS09435 (SANR_1830) - 1939126..1940391 (-) 1266 WP_020999829.1 PTS sugar transporter subunit IIC -
  SANR_RS09440 (SANR_1831) - 1940564..1941742 (+) 1179 WP_020999830.1 ROK family transcriptional regulator -
  SANR_RS09445 (SANR_1832) - 1941929..1943194 (-) 1266 WP_020999831.1 TRZ/ATZ family protein -
  SANR_RS09455 (SANR_1833) msrB 1943643..1944578 (-) 936 WP_003038887.1 peptide-methionine (R)-S-oxide reductase MsrB -
  SANR_RS09460 (SANR_1834) - 1944695..1945630 (-) 936 WP_003038863.1 dihydroorotate oxidase -
  SANR_RS09465 (SANR_1835) gdhA 1945972..1947318 (+) 1347 WP_003038859.1 NADP-specific glutamate dehydrogenase -
  SANR_RS09470 (SANR_1836) - 1947404..1947991 (-) 588 WP_003038909.1 DUF4352 domain-containing protein -
  SANR_RS09475 (SANR_1837) - 1948009..1948866 (-) 858 WP_003038916.1 mechanosensitive ion channel family protein -
  SANR_RS09480 (SANR_1838) sstT 1949024..1950130 (+) 1107 Protein_1866 serine/threonine transporter SstT -
  SANR_RS09485 (SANR_1839) - 1950089..1951777 (-) 1689 WP_020999833.1 recombinase family protein -
  SANR_RS11745 (SANR_1840) - 1951862..1952029 (-) 168 WP_003038850.1 hypothetical protein -
  SANR_RS09495 - 1952522..1952928 (-) 407 Protein_1869 sigma-70 family RNA polymerase sigma factor -
  SANR_RS12040 (SANR_1842) - 1953349..1955352 (-) 2004 WP_235044281.1 LPXTG cell wall anchor domain-containing protein -
  SANR_RS09505 (SANR_1843) - 1955607..1956227 (-) 621 WP_020999835.1 recombinase family protein -
  SANR_RS09510 (SANR_1844) - 1956537..1956887 (+) 351 WP_020999836.1 plasmid mobilization protein -
  SANR_RS09515 (SANR_1845) - 1956893..1958224 (+) 1332 WP_020999837.1 relaxase/mobilization nuclease domain-containing protein -
  SANR_RS09520 (SANR_1846) - 1958227..1959657 (-) 1431 WP_020999838.1 hypothetical protein -
  SANR_RS09525 (SANR_1847) - 1959674..1960948 (-) 1275 WP_020999839.1 hypothetical protein -
  SANR_RS09530 (SANR_1848) - 1960966..1961172 (-) 207 WP_020999840.1 helix-turn-helix domain-containing protein -
  SANR_RS09535 (SANR_1849) - 1961312..1961971 (-) 660 WP_041791290.1 hypothetical protein -
  SANR_RS09540 (SANR_1850) - 1962014..1970752 (-) 8739 WP_020999842.1 helicase-related protein -
  SANR_RS09545 (SANR_1851) - 1970822..1971829 (-) 1008 WP_020999843.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
  SANR_RS09550 (SANR_1852) - 1971822..1972427 (-) 606 WP_000612353.1 DUF6088 family protein -
  SANR_RS09555 (SANR_1853) - 1972505..1974208 (-) 1704 WP_020999844.1 DNA topoisomerase 3 -
  SANR_RS09560 (SANR_1854) - 1974296..1977352 (-) 3057 WP_020999845.1 VaFE repeat-containing surface-anchored protein -
  SANR_RS09565 (SANR_1855) - 1977449..1978978 (-) 1530 WP_020999846.1 CD1107 family mobile element protein -
  SANR_RS09570 (SANR_1856) - 1978953..1979192 (-) 240 WP_000711924.1 hypothetical protein -
  SANR_RS09575 (SANR_1857) - 1979205..1981337 (-) 2133 WP_020999847.1 CHAP domain-containing protein -
  SANR_RS09580 (SANR_1858) - 1981341..1983770 (-) 2430 WP_041791295.1 VirB4-like conjugal transfer ATPase, CD1110 family -
  SANR_RS09585 (SANR_1859) - 1983682..1984071 (-) 390 WP_020999849.1 PrgI family protein -
  SANR_RS09590 (SANR_1860) - 1984075..1984338 (-) 264 WP_020999850.1 hypothetical protein -
  SANR_RS09595 (SANR_1861) - 1984356..1985219 (-) 864 WP_000466908.1 VirB6/TrbL-like conjugal transfer protein, CD1112 family -
  SANR_RS11290 (SANR_1862) - 1985231..1985329 (-) 99 Protein_1890 Maff2 family mobile element protein -
  SANR_RS09600 (SANR_1863) ltrA 1985482..1987341 (-) 1860 WP_003033986.1 group II intron reverse transcriptase/maturase -
  SANR_RS11295 (SANR_1864) - 1988066..1988194 (-) 129 Protein_1892 Maff2 family mobile element protein -
  SANR_RS09610 (SANR_1865) - 1988198..1988509 (-) 312 WP_003034023.1 hypothetical protein -
  SANR_RS09615 (SANR_1866) - 1988674..1990458 (-) 1785 WP_020999851.1 VirD4-like conjugal transfer protein, CD1115 family -
  SANR_RS09620 (SANR_1867) - 1990455..1990940 (-) 486 WP_003034039.1 PcfB family protein -
  SANR_RS09625 (SANR_1868) - 1990937..1991788 (-) 852 WP_003034031.1 ATP-binding protein -
  SANR_RS09630 (SANR_1869) - 1991785..1992564 (-) 780 WP_003033989.1 replication initiator protein A -
  SANR_RS09635 (SANR_1870) - 1992673..1993152 (-) 480 WP_231847317.1 ClbS/DfsB family four-helix bundle protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 29319.85 Da        Isoelectric Point: 8.4284

>NTDB_id=61691 SANR_RS09370 WP_003038927.1 1926114..1926854(-) (comE/blpR) [Streptococcus anginosus C238]
MITIFVLEDDFVQQSRMERTIKEVMKKNSWKYRRIHIYGKPNQLLESITERGSHQLFFLDIQIKNESKRGFEIAEEIRRK
DPNATIVFVTTHSEFMPIIFQYKVAALDFIDKGLDERAFSRHVEEAINTVIEKQGRTVIEDSFNFETSLAMVQVPFHNIL
YFETSPTIHKVILHTKNERMEFYARISEIEKVDKRLYKCHQSYVVNLENILKVDKENGKVYFEDNEYCLVSRMRLKGLID
RIKKLQ

Nucleotide


Download         Length: 741 bp        

>NTDB_id=61691 SANR_RS09370 WP_003038927.1 1926114..1926854(-) (comE/blpR) [Streptococcus anginosus C238]
ATGATAACTATTTTTGTACTAGAAGATGATTTTGTACAACAATCTAGAATGGAGAGGACGATAAAAGAGGTTATGAAGAA
AAATTCTTGGAAATATCGTCGTATTCATATTTATGGGAAACCCAATCAACTACTTGAATCTATTACAGAAAGAGGTTCAC
ATCAACTTTTCTTTTTAGATATTCAAATAAAAAATGAATCAAAAAGAGGGTTTGAGATTGCAGAAGAAATTCGAAGAAAA
GATCCAAATGCAACAATTGTATTTGTAACAACCCATTCAGAATTTATGCCTATAATTTTTCAGTATAAAGTTGCGGCTCT
CGACTTTATTGATAAAGGATTAGATGAAAGAGCGTTTTCTAGACATGTTGAAGAAGCTATCAATACTGTGATAGAAAAGC
AAGGTCGTACAGTTATTGAAGATTCATTTAATTTTGAAACTTCATTAGCTATGGTCCAAGTGCCGTTTCATAATATTTTA
TATTTTGAAACATCGCCAACGATTCATAAAGTTATTTTACATACAAAAAATGAGAGAATGGAGTTTTATGCTCGTATTTC
AGAAATTGAAAAAGTAGATAAAAGACTTTATAAATGTCATCAATCTTATGTGGTAAATCTTGAAAATATTTTAAAAGTGG
ATAAAGAAAATGGTAAAGTATATTTTGAAGATAATGAATATTGTTTAGTATCAAGGATGAGATTAAAAGGGTTGATAGAT
AGAATAAAAAAACTTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-120)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.282

97.967

0.512
  comE/comE1 Streptococcus equinus JB1

45.267

98.78

0.447
  comE/comE2 Streptococcus equinus JB1

39.837

100

0.398
  comE/comE2 Streptococcus gordonii strain NCTC7865

36.885

99.187

0.366
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

36.885

99.187

0.366

Multiple sequence alignment