Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SCI_RS02030 Genome accession   NC_022238
Coordinates   390716..391471 (+) Length   251 a.a.
NCBI ID   WP_003070299.1    Uniprot ID   F9P4C7
Organism   Streptococcus constellatus subsp. pharyngis C1050     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 385716..396471
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCI_RS02015 (SCI_0400) - 386102..387667 (-) 1566 WP_006267112.1 ABC transporter substrate-binding protein/permease -
  SCI_RS02020 (SCI_0401) - 387795..389683 (+) 1889 Protein_378 DUF2207 family protein -
  SCI_RS02025 (SCI_0402) - 389750..390592 (+) 843 WP_006267591.1 undecaprenyl-diphosphate phosphatase -
  SCI_RS02030 (SCI_0403) mecA 390716..391471 (+) 756 WP_003070299.1 adaptor protein MecA Regulator
  SCI_RS02035 (SCI_0404) - 391462..392628 (+) 1167 WP_022524656.1 glycosyltransferase family 4 protein -
  SCI_RS02040 (SCI_0405) sufC 392720..393490 (+) 771 WP_006267171.1 Fe-S cluster assembly ATPase SufC -
  SCI_RS02045 (SCI_0406) sufD 393530..394792 (+) 1263 WP_006267649.1 Fe-S cluster assembly protein SufD -
  SCI_RS02050 (SCI_0407) - 394808..396040 (+) 1233 WP_020997620.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 29014.77 Da        Isoelectric Point: 4.1166

>NTDB_id=61578 SCI_RS02030 WP_003070299.1 390716..391471(+) (mecA) [Streptococcus constellatus subsp. pharyngis C1050]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDIEAVRSLETAEAENNMSTSDIEDQEENSDDLTQKYIYYI
LKFSSLKEAIVFSKTVDYAVNTSELYKMDGYYYLTILVDIEGHPKRYPAWLLASMREHAEDTDVTRAVLQEHGYLLLVNE
AVASLQKVKCS

Nucleotide


Download         Length: 756 bp        

>NTDB_id=61578 SCI_RS02030 WP_003070299.1 390716..391471(+) (mecA) [Streptococcus constellatus subsp. pharyngis C1050]
ATGGAAATGAAGCAAATCAGTGATACAACGATTAAGATCACAATAAAATTAGAAGATTTAGAAGAACGTGGAATGGAGAT
GGCAGATTTTCTCGTTCCGCAAGAAAAGACAGAAGAGTTTTTCTATGCAATTTTAGATGAGTTGGAAATGCCAGAGAGTT
TTTTGGATAGCGGTATGCTCAGTTTTCGTGTAACTCCTAAACCAGACCGACTGGATGTTTTTGTCACCAAGTCTAAGATT
GATAAGAATCTGAACTTTGATGATTTGGCAGATTTACCAGATGTAGAAGAGCTGTCTCAAATGTCTCCAGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGCAAAGACGATATTGAAGCTGTTCGGTCTTTGGAAACGGCAGAAGCAG
AAAATAATATGAGCACTTCTGACATAGAAGATCAAGAAGAAAACAGTGACGACCTTACTCAAAAATATATCTATTATATC
TTGAAATTTTCCAGCTTGAAAGAAGCGATTGTCTTTTCTAAAACAGTAGACTATGCTGTTAACACTTCGGAGTTGTACAA
AATGGATGGTTACTATTATTTAACAATCTTGGTTGATATTGAAGGACATCCTAAGCGTTATCCAGCTTGGCTTTTGGCTT
CTATGCGTGAACATGCGGAAGACACAGATGTGACAAGAGCTGTTTTGCAAGAGCATGGTTATTTATTGCTTGTCAACGAG
GCGGTTGCCAGTCTTCAAAAGGTTAAATGCTCATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P4C7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

66.532

98.805

0.657
  mecA Streptococcus pneumoniae D39

66.532

98.805

0.657
  mecA Streptococcus pneumoniae R6

66.532

98.805

0.657
  mecA Streptococcus pneumoniae TIGR4

66.129

98.805

0.653
  mecA Streptococcus mutans UA159

50

98.805

0.494
  mecA Streptococcus thermophilus LMD-9

46.304

100

0.474
  mecA Streptococcus thermophilus LMG 18311

45.914

100

0.47

Multiple sequence alignment