Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NQD66_RS08745 Genome accession   NZ_CP101995
Coordinates   1711070..1711744 (-) Length   224 a.a.
NCBI ID   WP_001238594.1    Uniprot ID   P0A4I0
Organism   Streptococcus agalactiae strain BCJB2983     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1706070..1716744
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NQD66_RS08720 (NQD66_08720) dltC 1706686..1706925 (-) 240 WP_000351975.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -
  NQD66_RS08725 (NQD66_08725) dltB 1706940..1708205 (-) 1266 WP_000613595.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -
  NQD66_RS08730 (NQD66_08730) dltA 1708202..1709737 (-) 1536 WP_000581010.1 D-alanine--poly(phosphoribitol) ligase subunit DltA -
  NQD66_RS08735 (NQD66_08735) - 1709750..1709872 (-) 123 WP_000806141.1 teichoic acid D-Ala incorporation-associated protein DltX -
  NQD66_RS08740 (NQD66_08740) dltS 1709883..1711070 (-) 1188 WP_000490537.1 two-component system sensor histidine kinase DltS -
  NQD66_RS08745 (NQD66_08745) ciaR 1711070..1711744 (-) 675 WP_001238594.1 two-component system response regulator DltR Regulator
  NQD66_RS08750 (NQD66_08750) rpmH 1712100..1712234 (-) 135 WP_000831903.1 50S ribosomal protein L34 -
  NQD66_RS08755 (NQD66_08755) - 1712418..1713773 (-) 1356 WP_000712235.1 YjiH family protein -
  NQD66_RS08760 (NQD66_08760) - 1714020..1715747 (-) 1728 WP_000429367.1 ABC transporter permease/substrate binding protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25504.44 Da        Isoelectric Point: 5.4971

>NTDB_id=614438 NQD66_RS08745 WP_001238594.1 1711070..1711744(-) (ciaR) [Streptococcus agalactiae strain BCJB2983]
MRLLVVEDEKSIAEAIQALLADKGYSVDLAFDGDDGLEYILTGLYDLVLLDIMLPKRSGLSVLKRVREAGLETPIIFLTA
KSQTYDKVNGLDLGADDYITKPFEADELLARIRLRTRQSSLIRANQLRLGNIRLNTDSHELESKESSVKLSNKEFLLMEV
FMRNAKQIIPKNQLISKVWGPSDNSEYNQLEVFISFLRKKLRFLKADIEIITTKGFGYSLEERT

Nucleotide


Download         Length: 675 bp        

>NTDB_id=614438 NQD66_RS08745 WP_001238594.1 1711070..1711744(-) (ciaR) [Streptococcus agalactiae strain BCJB2983]
ATGAGACTTCTTGTAGTTGAGGATGAAAAAAGTATAGCAGAGGCTATTCAGGCTTTATTGGCAGATAAAGGTTATTCTGT
TGATTTAGCATTTGATGGAGATGATGGGTTAGAATACATTTTGACAGGTCTCTATGATTTAGTCCTGTTGGATATTATGT
TACCCAAACGCTCAGGATTATCTGTTTTAAAAAGAGTGAGGGAAGCTGGTTTAGAAACCCCAATAATCTTTTTAACTGCA
AAATCACAGACTTATGATAAAGTTAATGGTTTAGATTTAGGGGCAGATGATTATATCACAAAACCCTTTGAAGCAGATGA
ATTGCTAGCTAGAATTAGGCTGAGAACCAGACAATCTTCTCTAATCAGAGCAAATCAATTGCGGCTTGGAAATATAAGGC
TTAACACAGATTCACATGAGCTAGAATCTAAAGAAAGTAGTGTAAAATTATCCAATAAAGAATTTCTCTTGATGGAAGTT
TTTATGCGAAATGCAAAGCAGATTATTCCTAAAAATCAGTTGATTTCTAAGGTTTGGGGACCTTCAGACAATTCAGAATA
TAACCAGTTAGAAGTATTTATTTCTTTTTTGCGAAAAAAATTGCGCTTTTTAAAAGCAGACATTGAAATAATAACCACTA
AGGGCTTTGGATATTCCTTGGAGGAGAGGACATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A4I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

37.838

99.107

0.375
  ciaR Streptococcus pneumoniae Rx1

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae D39

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae TIGR4

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae R6

37.387

99.107

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366
  covR Streptococcus salivarius strain HSISS4

35.371

100

0.362