Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NQD70_RS09460 Genome accession   NZ_CP101991
Coordinates   1842406..1843080 (-) Length   224 a.a.
NCBI ID   WP_001238594.1    Uniprot ID   P0A4I0
Organism   Streptococcus agalactiae strain BCJB4361     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1837406..1848080
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NQD70_RS09435 (NQD70_09440) dltC 1838022..1838261 (-) 240 WP_000351975.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -
  NQD70_RS09440 (NQD70_09445) dltB 1838276..1839541 (-) 1266 WP_000613595.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -
  NQD70_RS09445 (NQD70_09450) dltA 1839538..1841073 (-) 1536 WP_000581010.1 D-alanine--poly(phosphoribitol) ligase subunit DltA -
  NQD70_RS09450 (NQD70_09455) - 1841086..1841208 (-) 123 WP_000806141.1 teichoic acid D-Ala incorporation-associated protein DltX -
  NQD70_RS09455 (NQD70_09460) dltS 1841219..1842406 (-) 1188 WP_000490537.1 two-component system sensor histidine kinase DltS -
  NQD70_RS09460 (NQD70_09465) ciaR 1842406..1843080 (-) 675 WP_001238594.1 two-component system response regulator DltR Regulator
  NQD70_RS09465 (NQD70_09470) rpmH 1843436..1843570 (-) 135 WP_000831903.1 50S ribosomal protein L34 -
  NQD70_RS09470 (NQD70_09475) - 1843754..1845109 (-) 1356 WP_000712235.1 YjiH family protein -
  NQD70_RS09475 (NQD70_09480) - 1845356..1847083 (-) 1728 WP_309164555.1 ABC transporter permease/substrate binding protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25504.44 Da        Isoelectric Point: 5.4971

>NTDB_id=614012 NQD70_RS09460 WP_001238594.1 1842406..1843080(-) (ciaR) [Streptococcus agalactiae strain BCJB4361]
MRLLVVEDEKSIAEAIQALLADKGYSVDLAFDGDDGLEYILTGLYDLVLLDIMLPKRSGLSVLKRVREAGLETPIIFLTA
KSQTYDKVNGLDLGADDYITKPFEADELLARIRLRTRQSSLIRANQLRLGNIRLNTDSHELESKESSVKLSNKEFLLMEV
FMRNAKQIIPKNQLISKVWGPSDNSEYNQLEVFISFLRKKLRFLKADIEIITTKGFGYSLEERT

Nucleotide


Download         Length: 675 bp        

>NTDB_id=614012 NQD70_RS09460 WP_001238594.1 1842406..1843080(-) (ciaR) [Streptococcus agalactiae strain BCJB4361]
ATGAGACTTCTTGTAGTTGAGGATGAAAAAAGTATAGCAGAGGCTATTCAGGCTTTATTGGCAGATAAAGGTTATTCTGT
TGATTTAGCATTTGATGGAGATGATGGGTTAGAATACATTTTGACAGGTCTCTATGATTTAGTCCTGTTGGATATTATGT
TACCCAAACGCTCAGGATTATCTGTTTTAAAAAGAGTGAGGGAAGCTGGTTTAGAAACCCCAATAATCTTTTTAACTGCA
AAATCACAGACTTATGATAAAGTTAATGGTTTAGATTTAGGGGCAGATGATTATATCACAAAACCCTTTGAAGCAGATGA
ATTGCTAGCTAGAATTAGGCTGAGAACCAGACAATCTTCTCTAATCAGAGCAAATCAATTGCGGCTTGGAAATATAAGGC
TTAACACAGATTCACATGAGCTAGAATCTAAAGAAAGTAGTGTAAAATTATCCAATAAAGAATTTCTCTTGATGGAAGTT
TTTATGCGAAATGCAAAGCAGATTATTCCTAAAAATCAGTTGATTTCTAAGGTTTGGGGACCTTCAGACAATTCAGAATA
TAACCAGTTAGAAGTATTTATTTCTTTTTTGCGAAAAAAATTGCGCTTTTTAAAAGCAGACATTGAAATAATAACCACTA
AGGGCTTTGGATATTCCTTGGAGGAGAGGACATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A4I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

37.838

99.107

0.375
  ciaR Streptococcus pneumoniae Rx1

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae D39

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae TIGR4

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae R6

37.387

99.107

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366
  covR Streptococcus salivarius strain HSISS4

35.371

100

0.362