Detailed information NTG0613654

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: NPS18_RS08750
• Genome accession: NZ_CP101984
• Coordinates: 1773660..1775951 (-)
• Length: 763 a.a.
• NCBI ID: WP_002263352.1
• Uniprot ID: Q8DSC1
• Organism: Streptococcus mutans strain UA-159
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1768660..1780951

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NPS18_RS08730 (NPS18_08730)	-	1769195..1769665 (+)	471	WP_002263356.1	hypothetical protein	-
NPS18_RS08735 (NPS18_08735)	-	1770542..1771534 (+)	993	WP_002263355.1	PTS sugar transporter subunit IIB	-
NPS18_RS08740 (NPS18_08740)	-	1771569..1772387 (+)	819	WP_002263354.1	PTS mannose/fructose/sorbose transporter subunit IIC	-
NPS18_RS08745 (NPS18_08745)	-	1772402..1773328 (+)	927	WP_002263353.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
NPS18_RS08750 (NPS18_08750)	comA/nlmT	1773660..1775951 (-)	2292	WP_002263352.1	peptide cleavage/export ABC transporter	Regulator
NPS18_RS08755 (NPS18_08755)	-	1776501..1776854 (-)	354	WP_002263351.1	hypothetical protein	-
NPS18_RS08760 (NPS18_08760)	-	1777173..1777541 (+)	369	WP_002263350.1	DUF956 family protein	-
NPS18_RS08765 (NPS18_08765)	-	1777778..1778851 (-)	1074	WP_002263349.1	acyltransferase	-
NPS18_RS08770 (NPS18_08770)	serS	1779375..1780655 (+)	1281	WP_002263348.1	serine--tRNA ligase	-

Sequence

Protein

• Length: 763 a.a.
• Molecular weight: 86450.75 Da
• Isoelectric Point: 7.1052

>NTDB_id=613654 NPS18_RS08750 WP_002263352.1 1773660..1775951(-) (comA/nlmT) [Streptococcus mutans strain UA-159]
MNIFSYLLLTVVSVLLVNLFLEFIKYFFKTTPAMNKENSKKSSIFLWSRTRRFKFVPQVDNRDCGPAALASIAKHYGSYY
SLVHLRELTKTDRQGTTALGIIEAAKNIGFETYSLDADMSLFNYDDLIYPFIVHVVKNKRLQHYYVVYDDEGDSLIIGDP
DPSVKVIRMSKERFQHEWTGVAIFFSPKDDYQPQKDKRRGLTSFIPSFLKQKSLLFYIIMASLIITLIEIIGAFYLQVML
DEYIPSQKISTLGFITLGLIITYVAQQIIAFAKEYLLIILGQRLVIDVILTYIKHIFILPMSFFSTRRTGEITSRFTDAN
QIIDAVASTIFSIFLDISMVFIVGGVLLIQNVVLFFLALLCVPIYIIIVFAFMKMFGYLNYEVMESNAIMSSSVIEDING
IETIKSLTSEEVSYQRIDKEFVDFLEKSFRLHKYGAIQVSIKTAAKLILNIVILWYGARLVMTGKISVGQMIAFNVLLGY
FSSPIENMINLQIKLQSARIANTRLNEVYLVDSEFENNGELSEGSFLDGDISFEKLSYKYGYGRDTLSDINLTIKKGSKV
SLVGASGSGKTTLAKMIVNFYEPIQGLIRLNGYDLKDIDKTVLRQHINYLPQQAYVFSGTIMDNLTLGAKEDTIQEDIIR
ACEIAEIHSDIEQMPLGYQTELSDSTGVSGGQKQRIALARALLTQAPVLILDEATSSLDVLTEKKIVNNLMAMTNKTIVF
VAHRLSIAQRTDRIIVMDQGKIVEEGSHKELLAHKGFYYKLFN

Nucleotide

• Length: 2292 bp

>NTDB_id=613654 NPS18_RS08750 WP_002263352.1 1773660..1775951(-) (comA/nlmT) [Streptococcus mutans strain UA-159]
ATGAACATATTTTCTTATCTTCTTTTGACTGTAGTTTCAGTATTATTAGTCAATTTATTCTTAGAATTTATAAAATACTT
TTTTAAAACAACTCCAGCAATGAATAAGGAAAATTCTAAGAAATCTTCAATTTTTTTGTGGAGTCGAACTAGACGTTTTA
AATTTGTACCACAAGTCGATAATAGAGACTGTGGCCCGGCTGCTCTAGCCTCTATTGCCAAACATTATGGTTCATATTAT
TCCTTGGTTCATCTGCGTGAACTTACAAAGACAGATCGACAAGGCACCACAGCATTAGGCATCATTGAAGCTGCCAAAAA
TATTGGATTTGAAACTTACTCGCTAGATGCTGATATGTCTTTATTTAATTATGATGACCTTATTTACCCTTTTATTGTTC
ACGTTGTTAAAAATAAACGTCTTCAACATTACTATGTTGTTTATGACGATGAAGGAGATAGTCTAATCATCGGAGATCCA
GATCCTTCTGTCAAAGTTATTCGCATGTCTAAGGAGAGATTTCAGCATGAATGGACAGGTGTAGCTATCTTCTTTTCCCC
AAAGGATGATTATCAGCCTCAAAAAGATAAAAGAAGAGGATTAACAAGTTTCATACCTTCTTTTTTAAAGCAAAAGAGTC
TCTTGTTCTATATTATAATGGCGAGTTTAATCATTACTTTAATAGAAATTATTGGAGCTTTTTATCTCCAAGTAATGCTG
GATGAGTATATTCCCAGTCAAAAAATTTCAACTTTAGGCTTTATCACTTTAGGATTAATAATAACTTATGTTGCCCAACA
AATAATAGCTTTTGCAAAAGAGTACTTATTAATTATATTAGGACAAAGGCTGGTAATTGATGTTATACTTACTTATATTA
AGCACATTTTTATTCTTCCGATGTCTTTTTTTTCGACAAGACGAACGGGAGAAATCACATCTCGCTTCACTGATGCCAAT
CAAATTATTGATGCTGTGGCGTCAACAATTTTTTCTATTTTCTTAGACATTTCGATGGTATTTATAGTTGGTGGAGTATT
ATTAATTCAAAATGTCGTTTTATTTTTCCTAGCCTTGCTCTGCGTTCCTATCTACATTATCATTGTTTTTGCATTTATGA
AAATGTTTGGTTACTTAAACTATGAGGTAATGGAAAGTAATGCGATAATGTCTTCATCTGTTATTGAGGATATTAATGGA
ATAGAAACTATCAAATCTTTGACGAGTGAAGAAGTTAGCTATCAGAGAATTGACAAGGAATTTGTTGATTTTTTAGAGAA
ATCTTTTAGGCTGCATAAGTATGGAGCTATTCAAGTCTCAATTAAAACTGCTGCAAAGCTAATTTTGAATATCGTTATTC
TATGGTATGGAGCACGATTGGTTATGACCGGGAAAATTTCAGTGGGTCAAATGATTGCTTTTAATGTGCTTTTAGGATAT
TTTTCAAGCCCAATTGAAAATATGATTAATTTACAAATTAAGCTCCAATCAGCCCGCATAGCTAATACGCGTCTCAATGA
AGTCTATCTGGTCGATTCTGAGTTTGAAAATAATGGGGAGCTTTCAGAAGGCAGCTTTTTGGATGGGGATATCTCTTTTG
AAAAGTTATCTTACAAGTATGGTTATGGTCGTGATACTCTGTCAGATATCAATCTAACTATTAAAAAAGGTTCAAAGGTC
AGTCTGGTCGGAGCCTCTGGTTCTGGTAAAACGACTCTTGCCAAGATGATTGTCAATTTTTATGAACCTATACAGGGTCT
TATCCGTCTTAATGGCTATGACCTAAAAGATATAGATAAGACTGTTTTACGCCAGCATATTAACTATCTCCCCCAACAAG
CTTATGTCTTTAGTGGTACCATTATGGATAATCTGACCTTGGGAGCCAAGGAAGACACTATTCAGGAAGATATTATTCGA
GCCTGTGAAATTGCTGAGATTCATTCAGACATTGAACAAATGCCGCTGGGGTACCAGACTGAGTTATCTGATAGTACTGG
AGTTTCCGGTGGCCAGAAGCAGCGGATTGCCTTGGCTCGCGCTCTCTTAACCCAAGCTCCAGTTTTGATTTTGGATGAAG
CCACCAGCAGTCTGGATGTCCTGACTGAAAAGAAAATCGTCAACAACCTCATGGCCATGACCAATAAGACTATTGTTTTT
GTGGCACACCGTTTGAGTATTGCTCAACGGACAGACCGAATTATTGTTATGGATCAAGGTAAGATTGTGGAAGAAGGTAG
CCATAAGGAACTTTTAGCTCATAAAGGCTTCTACTACAAGCTGTTTAACTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (215-484)

• Peptidase C39 family (Peptidase_C39) (53-189)

• ABC transporter (ABC_tran) (547-696)

3D structure

• AlphaFold DB: Q8DSC1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.81	99.083	0.731
comA	Streptococcus mitis NCTC 12261	62.676	93.054	0.583
comA	Streptococcus pneumoniae Rx1	61.831	93.054	0.575
comA	Streptococcus pneumoniae D39	61.831	93.054	0.575
comA	Streptococcus pneumoniae R6	61.831	93.054	0.575
comA	Streptococcus mitis SK321	61.831	93.054	0.575
comA	Streptococcus pneumoniae TIGR4	61.549	93.054	0.573
comA	Streptococcus gordonii str. Challis substr. CH1	60.224	93.578	0.564