Detailed information NTG0061192

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: LBPG_RS11565
• Genome accession: NC_022112
• Coordinates: 2378758..2380950 (-)
• Length: 730 a.a.
• NCBI ID: WP_003567347.1
• Uniprot ID: A0A826HY20
• Organism: Lacticaseibacillus paracasei subsp. paracasei 8700:2
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2373758..2385950

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LBPG_RS11535 (LBPG_02290)	-	2373924..2374208 (-)	285	WP_003567331.1	bacteriocin immunity protein	-
LBPG_RS11540 (LBPG_02291)	-	2374401..2374697 (-)	297	WP_003567333.1	bacteriocin immunity protein	-
LBPG_RS11545 (LBPG_02292)	-	2374799..2376154 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
LBPG_RS11550 (LBPG_02293)	-	2376460..2376771 (-)	312	WP_003580849.1	hypothetical protein	-
LBPG_RS11555 (LBPG_02294)	-	2376844..2377194 (-)	351	WP_003567340.1	hypothetical protein	-
LBPG_RS11560 (LBPG_02295)	-	2377368..2378747 (-)	1380	WP_003567343.1	bacteriocin secretion accessory protein	-
LBPG_RS11565 (LBPG_02296)	comA	2378758..2380950 (-)	2193	WP_003567347.1	peptide cleavage/export ABC transporter	Regulator
LBPG_RS11570	-	2381416..2381553 (-)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
LBPG_RS11575 (LBPG_02298)	-	2381743..2383041 (+)	1299	WP_003567349.1	GHKL domain-containing protein	-
LBPG_RS11580 (LBPG_02299)	-	2383046..2383852 (+)	807	WP_003567351.1	LytTR family DNA-binding domain-containing protein	-
LBPG_RS11585	-	2384214..2384411 (-)	198	WP_003659579.1	hypothetical protein	-
LBPG_RS11590	-	2384958..2385197 (+)	240	WP_003567354.1	hypothetical protein	-
LBPG_RS11595 (LBPG_02303)	-	2385457..2385630 (-)	174	WP_032675994.1	bacteriocin	-
LBPG_RS11600 (LBPG_02304)	-	2385665..2385853 (-)	189	WP_003567358.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81262.49 Da
• Isoelectric Point: 7.2447

>NTDB_id=61192 LBPG_RS11565 WP_003567347.1 2378758..2380950(-) (comA) [Lacticaseibacillus paracasei subsp. paracasei 8700:2]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPANAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHTELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=61192 LBPG_RS11565 WP_003567347.1 2378758..2380950(-) (comA) [Lacticaseibacillus paracasei subsp. paracasei 8700:2]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAGGACTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGCGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTAACAACGTTACGCCAATACATCGAGTATGTACCGCAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATACTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

3D structure

• AlphaFold DB: A0A826HY20

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.635	98.356	0.577
comA	Streptococcus pneumoniae Rx1	58.078	98.356	0.571
comA	Streptococcus pneumoniae D39	58.078	98.356	0.571
comA	Streptococcus pneumoniae R6	58.078	98.356	0.571
comA	Streptococcus mitis SK321	57.939	98.356	0.57
comA	Streptococcus pneumoniae TIGR4	57.66	98.356	0.567
comA	Streptococcus gordonii str. Challis substr. CH1	57.103	98.356	0.562
comA/nlmT	Streptococcus mutans UA159	54.848	98.904	0.542