Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   K9N64_RS03525 Genome accession   NZ_CP084248
Coordinates   244817..246106 (+) Length   429 a.a.
NCBI ID   WP_002290101.1    Uniprot ID   A0A828ZUK2
Organism   Enterococcus lactis strain DH9003     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 239817..251106
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K9N64_RS03490 (K9N64_03480) - 240169..241059 (-) 891 WP_225479283.1 EcsC family protein -
  K9N64_RS03495 (K9N64_03485) - 241052..241216 (-) 165 WP_225479284.1 hypothetical protein -
  K9N64_RS03500 (K9N64_03490) - 241505..242050 (-) 546 WP_113820962.1 DUF1643 domain-containing protein -
  K9N64_RS03505 (K9N64_03495) - 242224..242523 (-) 300 WP_002312614.1 hypothetical protein -
  K9N64_RS03510 (K9N64_03500) - 242550..242858 (-) 309 WP_002317115.1 DUF960 domain-containing protein -
  K9N64_RS03515 (K9N64_03505) - 243012..243860 (-) 849 WP_002331982.1 LEM-3-like GIY-YIG domain-containing protein -
  K9N64_RS03520 (K9N64_03510) rlmH 243910..244389 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  K9N64_RS03525 (K9N64_03515) htrA 244817..246106 (+) 1290 WP_002290101.1 S1C family serine protease Regulator
  K9N64_RS03530 (K9N64_03520) ytpR 246145..246750 (-) 606 WP_002313997.1 YtpR family tRNA-binding protein -
  K9N64_RS03535 (K9N64_03525) - 246946..247410 (-) 465 WP_002292633.1 universal stress protein -
  K9N64_RS03540 (K9N64_03530) - 247432..247752 (-) 321 WP_002292632.1 thioredoxin family protein -
  K9N64_RS03545 (K9N64_03535) pepA 247895..248974 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  K9N64_RS03550 (K9N64_03540) - 249174..249524 (+) 351 WP_002309710.1 PepSY domain-containing protein -
  K9N64_RS03555 (K9N64_03545) - 249747..250694 (+) 948 WP_225479285.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44916.93 Da        Isoelectric Point: 4.5419

>NTDB_id=610273 K9N64_RS03525 WP_002290101.1 244817..246106(+) (htrA) [Enterococcus lactis strain DH9003]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=610273 K9N64_RS03525 WP_002290101.1 244817..246106(+) (htrA) [Enterococcus lactis strain DH9003]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A828ZUK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

60.169

82.517

0.496
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464