Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   KE3_RS08915 Genome accession   NC_021900
Coordinates   1771983..1772816 (-) Length   277 a.a.
NCBI ID   WP_081665472.1    Uniprot ID   -
Organism   Streptococcus lutetiensis 033     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1773224..1785917 1771983..1772816 flank 408


Gene organization within MGE regions


Location: 1771983..1785917
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KE3_RS08915 comD/comD2 1771983..1772816 (-) 834 WP_081665472.1 sensor histidine kinase Regulator
  KE3_RS08920 (KE3_1837) - 1773712..1774005 (-) 294 WP_020917489.1 bacteriocin immunity protein -
  KE3_RS08925 (KE3_1838) - 1774033..1774338 (-) 306 WP_020917490.1 bacteriocin immunity protein -
  KE3_RS08930 (KE3_1839) - 1774351..1774500 (-) 150 WP_020917491.1 hypothetical protein -
  KE3_RS08935 (KE3_1840) rsmA 1774907..1775779 (-) 873 WP_020917492.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
  KE3_RS08940 (KE3_1841) rnmV 1775902..1776471 (-) 570 WP_043895125.1 ribonuclease M5 -
  KE3_RS08945 (KE3_1842) - 1776464..1777234 (-) 771 WP_003066600.1 TatD family hydrolase -
  KE3_RS11105 - 1777371..1777448 (-) 78 WP_230318136.1 hypothetical protein -
  KE3_RS11015 (KE3_1844) - 1777649..1777762 (-) 114 WP_231557400.1 Cna B-type domain-containing protein -
  KE3_RS11020 (KE3_1845) - 1777759..1778460 (-) 702 WP_228380538.1 Cna B-type domain-containing protein -
  KE3_RS11025 - 1778524..1778730 (-) 207 Protein_1763 thioester domain-containing protein -
  KE3_RS11030 (KE3_1846) - 1778734..1779060 (-) 327 WP_041973728.1 hypothetical protein -
  KE3_RS08960 (KE3_1848) - 1779540..1780508 (+) 969 WP_013852274.1 L-lactate dehydrogenase -
  KE3_RS11035 - 1780996..1781340 (-) 345 WP_043895126.1 hypothetical protein -
  KE3_RS11040 (KE3_1849) - 1781370..1781873 (+) 504 WP_228380496.1 CPBP family intramembrane glutamic endopeptidase -
  KE3_RS08975 (KE3_1850) - 1781993..1783098 (-) 1106 Protein_1768 IS3 family transposase -
  KE3_RS08985 (KE3_1853) - 1783406..1784224 (-) 819 WP_020917499.1 metal ABC transporter permease -
  KE3_RS08990 (KE3_1854) - 1784235..1784948 (-) 714 WP_013852281.1 metal ABC transporter ATP-binding protein -
  KE3_RS08995 (KE3_1855) - 1784991..1785917 (-) 927 WP_009855033.1 metal ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 277 a.a.        Molecular weight: 31687.17 Da        Isoelectric Point: 4.6655

>NTDB_id=60843 KE3_RS08915 WP_081665472.1 1771983..1772816(-) (comD/comD2) [Streptococcus lutetiensis 033]
MVSYFLFMDAVAIVKPFHNTVNDAIRGIVAFIYLILLFVFLFYLNFRHGQEQKNELLRNQEMELAALENYSKHVESLYQE
VRSFRHDYANVLMSLKVGIDQGNLDDIKKIYNEITANSTKLVKNNKFDLTRLANIIDSGVKSFMSAKFLQAENQGVAISL
EVAKKMENPSMPLIYYIRILSILFDNAIEAALESETPEISVANFYQDGNFVFMIENSTKEKSVDLTKIFERGYSTKGENC
GLGLATLMDFQDDDENLSVETRSSDYTFTQVVRIFDA

Nucleotide


Download         Length: 834 bp        

>NTDB_id=60843 KE3_RS08915 WP_081665472.1 1771983..1772816(-) (comD/comD2) [Streptococcus lutetiensis 033]
ATGGTCTCTTATTTTTTATTCATGGATGCCGTTGCTATTGTAAAACCTTTTCATAATACTGTTAACGATGCAATAAGGGG
AATTGTTGCTTTCATTTATCTCATCCTTCTTTTTGTCTTCCTCTTTTATCTTAATTTCCGTCATGGGCAAGAGCAGAAAA
ATGAATTGCTTCGTAACCAGGAAATGGAATTGGCGGCCTTGGAAAATTATAGCAAGCACGTGGAGAGTTTGTATCAGGAG
GTTCGCAGTTTCAGGCATGACTACGCTAATGTCCTGATGAGTTTAAAGGTTGGAATTGATCAAGGCAATCTTGATGACAT
CAAGAAAATTTACAACGAAATCACAGCCAATTCGACGAAGCTAGTCAAGAATAATAAATTTGACCTGACTCGCTTGGCTA
ACATCATAGACAGCGGCGTCAAAAGCTTCATGTCAGCTAAATTTTTGCAAGCCGAAAATCAAGGGGTTGCAATTAGTCTA
GAAGTCGCCAAAAAAATGGAAAATCCTAGCATGCCATTAATTTATTACATTCGAATTTTGTCGATTCTGTTTGATAATGC
CATAGAAGCCGCTTTGGAGTCAGAAACTCCAGAAATCTCAGTCGCTAATTTTTACCAAGATGGTAACTTTGTTTTCATGA
TTGAGAATTCAACTAAGGAAAAATCAGTGGATTTAACTAAGATTTTTGAGCGTGGCTACTCAACTAAGGGAGAAAATTGT
GGACTTGGTCTAGCCACACTAATGGATTTCCAAGATGACGACGAAAATCTGTCAGTTGAAACCCGCAGCTCAGATTACAC
ATTTACACAAGTTGTCCGAATTTTTGATGCATAA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(177-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus equinus JB1

87.726

100

0.877
  comD/comD3 Streptococcus equinus JB1

82.657

97.834

0.809
  comD/blpH Streptococcus mutans UA159

39.051

98.917

0.386
  comD/comD1 Streptococcus equinus JB1

46.32

83.394

0.386

Multiple sequence alignment