Detailed information NTG0606864

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: LA346_RS10610
• Genome accession: NZ_CP083627
• Coordinates: 2073253..2073957 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain FDAARGOS_1508
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2068253..2078957

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LA346_RS10580 (LA346_10580)	-	2068298..2069041 (-)	744	Protein_2071	potassium channel family protein	-
LA346_RS10585 (LA346_10585)	-	2069088..2069342 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LA346_RS10590 (LA346_10590)	relB	2069344..2069586 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
LA346_RS10595 (LA346_10595)	-	2069780..2071036 (+)	1257	WP_000530078.1	ISL3 family transposase	-
LA346_RS10600 (LA346_10600)	vicX	2071100..2071909 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
LA346_RS10605 (LA346_10605)	micB	2071911..2073260 (-)	1350	WP_000886213.1	cell wall metabolism sensor histidine kinase VicK	Regulator
LA346_RS10610 (LA346_10610)	micA	2073253..2073957 (-)	705	WP_000722076.1	response regulator YycF	Regulator
LA346_RS10615 (LA346_10615)	mutY	2074013..2075188 (-)	1176	WP_000886152.1	A/G-specific adenine glycosylase	-
LA346_RS10935	-	2075285..2075410 (+)	126	WP_001818232.1	hypothetical protein	-
LA346_RS10620 (LA346_10620)	-	2075516..2077186 (-)	1671	WP_000845285.1	formate--tetrahydrofolate ligase	-
LA346_RS10625 (LA346_10625)	coaB	2077416..2078105 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
LA346_RS10630 (LA346_10630)	coaC	2078117..2078668 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=606864 LA346_RS10610 WP_000722076.1 2073253..2073957(-) (micA) [Streptococcus pneumoniae strain FDAARGOS_1508]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=606864 LA346_RS10610 WP_000722076.1 2073253..2073957(-) (micA) [Streptococcus pneumoniae strain FDAARGOS_1508]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38