Detailed information NTG0605575

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: LAE52_RS11850
• Genome accession: NZ_CP083392
• Coordinates: 2293494..2295656 (-)
• Length: 720 a.a.
• NCBI ID: WP_005720995.1
• Uniprot ID: A0A135ZGN3
• Organism: Lactobacillus crispatus strain Lc1226
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2288494..2300656

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LAE52_RS11805 (LAE52_11825)	-	2288771..2288980 (-)	210	WP_003549779.1	helix-turn-helix domain-containing protein	-
LAE52_RS11810 (LAE52_11830)	-	2288995..2289534 (-)	540	WP_005721009.1	hypothetical protein	-
LAE52_RS11815 (LAE52_11835)	-	2289539..2289721 (-)	183	WP_005721008.1	hypothetical protein	-
LAE52_RS11820 (LAE52_11840)	-	2289889..2290104 (-)	216	WP_005721007.1	hypothetical protein	-
LAE52_RS11825 (LAE52_11845)	-	2290174..2290368 (-)	195	WP_005721006.1	bacteriocin	-
LAE52_RS11830 (LAE52_11850)	-	2290386..2290637 (-)	252	WP_005726423.1	Blp family class II bacteriocin	-
LAE52_RS11835 (LAE52_11855)	-	2291230..2291427 (-)	198	WP_005721002.1	hypothetical protein	-
LAE52_RS11840 (LAE52_11860)	-	2291428..2292732 (-)	1305	WP_005721000.1	thioredoxin domain-containing protein	-
LAE52_RS11845 (LAE52_11865)	-	2292887..2293483 (-)	597	WP_005720997.1	hypothetical protein	-
LAE52_RS11850 (LAE52_11870)	comA	2293494..2295656 (-)	2163	WP_005720995.1	peptide cleavage/export ABC transporter	Regulator
LAE52_RS11855 (LAE52_11875)	-	2295780..2296580 (-)	801	WP_005720993.1	LytR/AlgR family response regulator transcription factor	-
LAE52_RS11860 (LAE52_11880)	-	2296573..2297289 (-)	717	Protein_2299	GHKL domain-containing protein	-
LAE52_RS11865 (LAE52_11885)	-	2297315..2298349 (-)	1035	WP_005729050.1	IS30 family transposase	-
LAE52_RS11870 (LAE52_11890)	-	2298417..2299079 (-)	663	WP_224052975.1	hypothetical protein	-
LAE52_RS13075	-	2299067..2299198 (-)	132	WP_005720990.1	bacteriocin-like peptide, LSEI_2386 family	-

Sequence

Protein

• Length: 720 a.a.
• Molecular weight: 81317.69 Da
• Isoelectric Point: 8.1038

>NTDB_id=605575 LAE52_RS11850 WP_005720995.1 2293494..2295656(-) (comA) [Lactobacillus crispatus strain Lc1226]
MLLQYKSIYVPQVDESDCGVACLAMILKKYHSRVFLAHLRHSARTNLEGTTALGLVKTAQAFNLKTEAVKADMSLFDPDA
DIQYPFIVHVLKQGELLHYYVVIKATKNYLVIADPDPSVGLTKMSKEKFSQEWTGIALFMVPNDDFEPLKEKKQNLWSLF
PYMFKQKKLVTNIILAALLMTIISICSSYFLQGLIDTYIPSGTYQTLSILAIGLLIAYVFNSIFSYGQNFLLDVLGQRLS
IDLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGIVLAIQNSTLFVITLLSLPIY
AVVILSFSKKFEKMNNDQMESNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTFI
QLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQNRLNEVYMVKSEFQKDAQIRDAK
QLAGEIEYHHVDYHYGYGVDVLKDINLKIEPNDKLAIVGMSGSGKSTMVKLLVDFFSPSKGKLTFNGFNSTKVDKHVLRS
YVNYVPQTPYIFSGTIKENLLLGSRPDITEKDILKACQIAEIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLS
PAKILIFDEATSGLDTITEKKVVDNLMKLKDKTIIFIAHRLAIAQRTNNILVVDHGQIVEQGSHEKLMQKHGFYYNLVEN

Nucleotide

• Length: 2163 bp

>NTDB_id=605575 LAE52_RS11850 WP_005720995.1 2293494..2295656(-) (comA) [Lactobacillus crispatus strain Lc1226]
ATGTTACTACAGTATAAATCAATTTATGTACCACAAGTAGACGAATCAGATTGTGGAGTTGCATGCTTAGCTATGATTCT
TAAAAAATATCATTCTAGAGTATTTTTAGCCCATTTACGTCATTCAGCCCGCACTAATTTAGAAGGGACTACCGCTCTGG
GCTTAGTTAAAACAGCACAAGCATTTAATCTAAAAACTGAAGCAGTTAAAGCTGACATGTCCTTGTTTGATCCTGATGCA
GACATTCAATATCCTTTCATCGTACACGTCTTAAAGCAAGGCGAATTACTCCACTATTATGTTGTGATTAAGGCAACCAA
AAATTATTTAGTGATTGCTGATCCGGATCCTAGCGTTGGTTTAACGAAAATGTCTAAAGAAAAGTTTTCTCAAGAATGGA
CGGGAATTGCCCTTTTTATGGTCCCAAATGATGATTTTGAGCCACTCAAAGAGAAAAAGCAAAATCTGTGGTCACTATTT
CCATACATGTTCAAACAAAAGAAACTAGTCACTAATATTATTTTGGCTGCTCTTTTGATGACAATCATTAGTATTTGTAG
CTCATACTTCTTGCAAGGCTTAATTGATACTTATATTCCTAGCGGTACATACCAAACTTTGTCGATCCTAGCTATTGGTT
TATTGATAGCATATGTTTTCAACTCTATCTTTTCTTACGGGCAAAATTTTCTATTGGATGTTCTAGGTCAGCGATTAAGT
ATTGATCTTAACTTACAATACATTCGCCATATTTTTGAATTACCAATGGAATTCTTCGTAACTCGTAGAACAGGGGAAAT
TACCTCAAGGTTCTCTGATGCTAGTCGAATTATTGACGCACTCGCCAGTACAGTTATTTCATTATTTCTTGATCTTTCAA
TTGTAATTGTGATGGGAATAGTTTTGGCAATTCAAAATTCCACTCTATTTGTGATTACTCTACTGTCTTTGCCAATTTAT
GCAGTGGTGATTCTTAGCTTTTCTAAGAAATTTGAAAAGATGAATAATGATCAGATGGAGAGTAATGCTGTCTTAAGTTC
TTCAGTAATTGAAGATATTCAAGGAATTGAAACAATCAAAGCTTTAAATAGCGAACAAACACGTTATCGTAAGATTGATA
GTCAATTCGTCGATTACCTCAAGAAATCTTTTCGTTACAGTAAAACTGAATCTTTGCAGTCAGCTTTAAAGACCTTCATT
CAGTTATCTCTCAATGTAATTATCCTCTGGGTAGGGGCTAAGGTTGTAATGAACGGGCAGATGAGCATTGGTCAATTAAT
GACCTTCAACGCATTACTATCGTATTTTGTAGATCCACTTCAGAGCATTATTAATCTTCAACCAACTCTACAATCAGCTA
ATGTAGCACAAAATCGATTGAATGAAGTATACATGGTTAAGAGTGAGTTCCAGAAAGATGCTCAGATTAGGGATGCCAAG
CAATTAGCAGGTGAGATTGAATATCATCATGTTGACTATCATTATGGCTATGGAGTCGATGTATTAAAAGATATTAATTT
AAAAATCGAACCCAATGATAAGTTGGCAATCGTAGGGATGAGTGGCTCAGGTAAGTCTACTATGGTCAAACTTTTAGTTG
ATTTCTTCTCTCCAAGCAAAGGCAAGTTAACTTTTAATGGATTTAATTCTACTAAAGTAGATAAGCATGTCTTACGGTCA
TACGTAAACTATGTTCCCCAAACACCATACATCTTCTCAGGAACAATCAAAGAAAATCTGCTCTTAGGTAGTCGACCAGA
TATTACAGAAAAAGATATATTGAAAGCCTGTCAGATAGCAGAAATTGAGTCTGAAATCGAACAATTACCACTGCAGTTTG
AAACCAAGATGGATGAAAATGCCAAGATTTTATCCGGTGGGCAAAAGCAAAGGCTAACTATTGCACGTGCATTATTGTCA
CCGGCTAAAATTTTAATTTTTGATGAAGCCACTAGCGGGCTTGATACGATTACAGAGAAAAAAGTAGTAGATAATTTAAT
GAAATTAAAAGATAAAACTATTATTTTTATTGCTCATCGTTTAGCAATTGCACAAAGGACTAACAATATTCTGGTTGTAG
ATCATGGTCAAATTGTTGAGCAAGGAAGTCATGAGAAATTAATGCAGAAACATGGCTTTTACTATAACTTAGTTGAGAAT
TAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (171-440)

• ABC transporter (ABC_tran) (502-652)

• Peptidase C39 family (Peptidase_C39) (9-144)

3D structure

• AlphaFold DB: A0A135ZGN3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis SK321	56.643	99.306	0.562
comA	Streptococcus pneumoniae D39	56.503	99.306	0.561
comA	Streptococcus pneumoniae R6	56.503	99.306	0.561
comA	Streptococcus mitis NCTC 12261	56.503	99.306	0.561
comA	Streptococcus pneumoniae Rx1	56.503	99.306	0.561
comA	Streptococcus pneumoniae TIGR4	56.364	99.306	0.56
comA	Streptococcus gordonii str. Challis substr. CH1	55.664	99.306	0.553
comA/nlmT	Streptococcus mutans UA159	53.814	98.333	0.529