Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   K9O36_RS01225 Genome accession   NZ_CP083179
Coordinates   244813..246102 (-) Length   429 a.a.
NCBI ID   WP_002294152.1    Uniprot ID   A0AAV3GR07
Organism   Enterococcus faecium strain H7     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 219349..278500 244813..246102 within 0


Gene organization within MGE regions


Location: 219349..278500
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K9O36_RS01085 - 219610..220254 (+) 645 WP_233976252.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
  K9O36_RS01090 - 220261..221268 (+) 1008 WP_002288240.1 sugar kinase -
  K9O36_RS01095 kduI 221284..222126 (+) 843 WP_002288239.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
  K9O36_RS01100 - 222146..222949 (+) 804 WP_002294167.1 gluconate 5-dehydrogenase -
  K9O36_RS01105 fni 223198..224262 (-) 1065 WP_002288234.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  K9O36_RS01110 - 224259..225344 (-) 1086 WP_002288233.1 phosphomevalonate kinase -
  K9O36_RS01115 mvaD 225357..226334 (-) 978 WP_002288232.1 diphosphomevalonate decarboxylase -
  K9O36_RS01120 mvk 226327..227271 (-) 945 WP_002288231.1 mevalonate kinase -
  K9O36_RS01125 - 227587..228246 (+) 660 WP_002294164.1 deoxynucleoside kinase -
  K9O36_RS01130 - 228331..229236 (+) 906 WP_002294163.1 magnesium transporter CorA family protein -
  K9O36_RS01135 - 229238..229870 (-) 633 WP_002294161.1 pentapeptide repeat-containing protein -
  K9O36_RS01140 infC 230190..230714 (+) 525 WP_002293357.1 translation initiation factor IF-3 -
  K9O36_RS01145 rpmI 230786..230986 (+) 201 WP_002289309.1 50S ribosomal protein L35 -
  K9O36_RS01150 rplT 231039..231398 (+) 360 WP_002289310.1 50S ribosomal protein L20 -
  K9O36_RS01155 - 231650..232987 (+) 1338 WP_002289312.1 hypothetical protein -
  K9O36_RS01160 - 233035..235164 (+) 2130 WP_002289314.1 hydantoinase/oxoprolinase family protein -
  K9O36_RS01165 - 235139..235828 (+) 690 WP_002289315.1 hypothetical protein -
  K9O36_RS01170 - 236236..236922 (-) 687 WP_002289316.1 GntR family transcriptional regulator -
  K9O36_RS01175 - 237058..237252 (-) 195 WP_002315615.1 hypothetical protein -
  K9O36_RS01180 - 237302..237742 (-) 441 WP_002289317.1 thioesterase family protein -
  K9O36_RS01185 - 237746..238591 (-) 846 WP_002289318.1 NAD(P)H-hydrate dehydratase -
  K9O36_RS01190 pepV 238740..240158 (+) 1419 WP_002294157.1 dipeptidase PepV -
  K9O36_RS01195 - 240215..241162 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  K9O36_RS01200 - 241385..241735 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  K9O36_RS01205 pepA 241935..243014 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  K9O36_RS01210 - 243158..243478 (+) 321 WP_002287837.1 thioredoxin family protein -
  K9O36_RS01215 - 243500..243964 (+) 465 WP_002287838.1 universal stress protein -
  K9O36_RS01220 ytpR 244169..244774 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  K9O36_RS01225 htrA 244813..246102 (-) 1290 WP_002294152.1 S1C family serine protease Regulator
  K9O36_RS01230 rlmH 246530..247009 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  K9O36_RS01235 - 247119..248264 (+) 1146 WP_233976253.1 recombinase family protein -
  K9O36_RS01240 - 248261..248683 (+) 423 WP_010721782.1 hypothetical protein -
  K9O36_RS01245 - 248941..249144 (+) 204 WP_071854798.1 hypothetical protein -
  K9O36_RS01250 - 249253..249561 (+) 309 WP_071854799.1 DUF960 domain-containing protein -
  K9O36_RS01255 - 249588..249887 (+) 300 WP_172921415.1 4'-phosphopantetheinyl transferase -
  K9O36_RS01260 - 250060..250611 (+) 552 WP_233976254.1 DUF1643 domain-containing protein -
  K9O36_RS01265 - 250757..251050 (+) 294 WP_071854802.1 Mor transcription activator family protein -
  K9O36_RS01270 - 251043..251339 (+) 297 WP_086317326.1 hypothetical protein -
  K9O36_RS01275 - 251410..252414 (+) 1005 WP_233976255.1 DUF4767 domain-containing protein -
  K9O36_RS01280 - 252749..253948 (-) 1200 WP_025479669.1 hypothetical protein -
  K9O36_RS01285 - 254086..254919 (+) 834 WP_071854805.1 replication initiation factor domain-containing protein -
  K9O36_RS01290 - 254963..255127 (+) 165 WP_002340116.1 hypothetical protein -
  K9O36_RS01295 - 255102..255368 (+) 267 WP_002340115.1 hypothetical protein -
  K9O36_RS01300 - 255635..257008 (+) 1374 WP_233976256.1 recombinase family protein -
  K9O36_RS01305 - 257012..258649 (+) 1638 WP_071854806.1 recombinase family protein -
  K9O36_RS01310 - 258886..260649 (+) 1764 WP_233976257.1 DNA methyltransferase -
  K9O36_RS01315 - 260699..261481 (-) 783 WP_233976258.1 site-specific DNA-methyltransferase -
  K9O36_RS01320 - 261482..264157 (-) 2676 WP_233976259.1 DEAD/DEAH box helicase -
  K9O36_RS01325 - 264671..265720 (+) 1050 WP_052410492.1 dsDNA nuclease domain-containing protein -
  K9O36_RS01330 - 265720..267408 (+) 1689 WP_233976260.1 hypothetical protein -
  K9O36_RS01335 - 267590..268099 (+) 510 WP_002296569.1 DUF1456 family protein -
  K9O36_RS01340 - 268199..268849 (+) 651 WP_002312640.1 hypothetical protein -
  K9O36_RS01345 - 269300..270238 (+) 939 WP_002291914.1 2-dehydropantoate 2-reductase -
  K9O36_RS01350 - 270251..271303 (+) 1053 WP_002291912.1 PTS sugar transporter subunit IIC -
  K9O36_RS01355 - 271569..272204 (+) 636 WP_002330002.1 DUF998 domain-containing protein -
  K9O36_RS01360 - 272437..272841 (+) 405 WP_002292291.1 organic hydroperoxide resistance protein -
  K9O36_RS01365 - 272974..274017 (+) 1044 WP_002292292.1 hypothetical protein -
  K9O36_RS01370 - 274032..274595 (+) 564 WP_002330004.1 restriction endonuclease subunit S -
  K9O36_RS01375 - 275150..276790 (+) 1641 WP_002294751.1 membrane protein -
  K9O36_RS01380 - 277044..277358 (+) 315 Protein_275 hypothetical protein -
  K9O36_RS01385 - 277663..278223 (-) 561 WP_002294749.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44871.87 Da        Isoelectric Point: 4.5419

>NTDB_id=604960 K9O36_RS01225 WP_002294152.1 244813..246102(-) (htrA) [Enterococcus faecium strain H7]
MDRKNVTPKMKKSKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=604960 K9O36_RS01225 WP_002294152.1 244813..246102(-) (htrA) [Enterococcus faecium strain H7]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAGTAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(9-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.269

96.27

0.513
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464