Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   K8Z62_RS01185 Genome accession   NZ_CP082963
Coordinates   243197..244486 (-) Length   429 a.a.
NCBI ID   WP_002290101.1    Uniprot ID   A0A828ZUK2
Organism   Enterococcus lactis strain HJS001     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 238197..249486
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K8Z62_RS01160 (K8Z62_01160) pepA 238644..239723 (+) 1080 WP_002292630.1 glutamyl aminopeptidase -
  K8Z62_RS01165 (K8Z62_01165) - 239866..240186 (+) 321 WP_002292632.1 thioredoxin family protein -
  K8Z62_RS01170 (K8Z62_01170) - 240208..240672 (+) 465 WP_002292633.1 universal stress protein -
  K8Z62_RS01175 (K8Z62_01175) ytpR 240877..241482 (+) 606 WP_002292634.1 YtpR family tRNA-binding protein -
  K8Z62_RS01180 (K8Z62_01180) - 241800..243017 (+) 1218 WP_104771242.1 IS110 family transposase -
  K8Z62_RS01185 (K8Z62_01185) htrA 243197..244486 (-) 1290 WP_002290101.1 S1C family serine protease Regulator
  K8Z62_RS01190 (K8Z62_01190) rlmH 244914..245393 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  K8Z62_RS01195 (K8Z62_01195) - 245573..246697 (+) 1125 WP_223493815.1 hypothetical protein -
  K8Z62_RS01200 (K8Z62_01200) - 247062..247703 (+) 642 Protein_240 transposase -
  K8Z62_RS01205 (K8Z62_01205) - 247709..248668 (-) 960 WP_002293280.1 IS30-like element IS6770 family transposase -
  K8Z62_RS01210 (K8Z62_01210) - 248763..249299 (+) 537 Protein_242 IS256-like element ISEfa13 family transposase -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44916.93 Da        Isoelectric Point: 4.5419

>NTDB_id=603967 K8Z62_RS01185 WP_002290101.1 243197..244486(-) (htrA) [Enterococcus lactis strain HJS001]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=603967 K8Z62_RS01185 WP_002290101.1 243197..244486(-) (htrA) [Enterococcus lactis strain HJS001]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCAGCCGGTGAAACAGTTGTCGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAATCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGGACGAAAGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGT
CGAAACGGTTGCCTCTTTTGGTGACTCAAGCGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCTTTGAATCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATATGATGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGCGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCAAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A828ZUK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

60.169

82.517

0.496
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464