Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   K8B76_RS00220 Genome accession   NZ_CP082820
Coordinates   41876..43225 (+) Length   449 a.a.
NCBI ID   WP_000801625.1    Uniprot ID   C1C9U7
Organism   Streptococcus pneumoniae strain SCAID PHRX1-2021     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 36876..48225
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K8B76_RS00195 (K8B76_00195) plsX 36995..37987 (+) 993 WP_000717460.1 phosphate acyltransferase PlsX -
  K8B76_RS00200 (K8B76_00200) - 37993..38226 (+) 234 WP_000136447.1 acyl carrier protein -
  K8B76_RS00205 (K8B76_00205) - 38263..38562 (+) 300 Protein_34 transposase family protein -
  K8B76_RS00210 (K8B76_00210) blpU 38765..38995 (+) 231 WP_001093068.1 bacteriocin-like peptide BlpU -
  K8B76_RS10540 - 38998..39123 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  K8B76_RS00215 (K8B76_00215) comA 39710..41863 (+) 2154 WP_000668287.1 peptide cleavage/export ABC transporter ComA Regulator
  K8B76_RS00220 (K8B76_00220) comB 41876..43225 (+) 1350 WP_000801625.1 competence pheromone export protein ComB Regulator
  K8B76_RS00225 (K8B76_00225) purC 43395..44102 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  K8B76_RS10950 - 44113..44247 (+) 135 WP_000429437.1 hypothetical protein -
  K8B76_RS00230 (K8B76_00230) - 44304..48029 (+) 3726 WP_000361214.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49583.43 Da        Isoelectric Point: 5.3895

>NTDB_id=602518 K8B76_RS00220 WP_000801625.1 41876..43225(+) (comB) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQSEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=602518 K8B76_RS00220 WP_000801625.1 41876..43225(+) (comB) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAATCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1C9U7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae TIGR4

99.332

100

0.993
  comB Streptococcus pneumoniae Rx1

99.109

100

0.991
  comB Streptococcus pneumoniae D39

99.109

100

0.991
  comB Streptococcus pneumoniae R6

99.109

100

0.991
  comB Streptococcus mitis SK321

94.878

100

0.949
  comB Streptococcus mitis NCTC 12261

94.432

100

0.944
  comB Streptococcus gordonii str. Challis substr. CH1

55.333

100

0.555