Detailed information NTG0600329

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: K4200_RS12460
• Genome accession: NZ_CP082231
• Coordinates: 2543347..2544645 (+)
• Length: 432 a.a.
• NCBI ID: WP_070416083.1
• Uniprot ID: -
• Organism: Enterococcus faecalis strain E006
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2538347..2549645

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K4200_RS12455 (K4200_12455)	rlmH	2542467..2542946 (-)	480	WP_002355021.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
K4200_RS12460 (K4200_12460)	htrA	2543347..2544645 (+)	1299	WP_070416083.1	S1C family serine protease	Regulator
K4200_RS12465 (K4200_12465)	ytpR	2544692..2545312 (-)	621	WP_002361057.1	YtpR family tRNA-binding protein	-
K4200_RS12470 (K4200_12470)	-	2545523..2545978 (-)	456	WP_002385249.1	universal stress protein	-
K4200_RS12475 (K4200_12475)	-	2546126..2546440 (-)	315	WP_002355015.1	thioredoxin family protein	-
K4200_RS12480 (K4200_12480)	pepA	2546452..2547528 (-)	1077	WP_002355013.1	glutamyl aminopeptidase	-
K4200_RS12485 (K4200_12485)	-	2547835..2548176 (+)	342	WP_002355012.1	PepSY domain-containing protein	-

Sequence

Protein

• Length: 432 a.a.
• Molecular weight: 44904.01 Da
• Isoelectric Point: 4.9047

>NTDB_id=600329 K4200_RS12460 WP_070416083.1 2543347..2544645(+) (htrA) [Enterococcus faecalis strain E006]
MQRKDVTPNSDKKSLLQKFEIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide

• Length: 1299 bp

>NTDB_id=600329 K4200_RS12460 WP_070416083.1 2543347..2544645(+) (htrA) [Enterococcus faecalis strain E006]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGAGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCTCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGCG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCGATTG
GTTCCCCTCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCCATCAATCCAGGAAACTCCGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGCGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (132-277)

• PDZ domain (PDZ_2) (319-416)

• Peptidase family M50 (Peptidase_M50) (8-416)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	53.171	94.907	0.505
htrA	Streptococcus mutans UA159	58.63	84.491	0.495
htrA	Streptococcus mitis NCTC 12261	55.135	85.648	0.472
htrA	Streptococcus pneumoniae TIGR4	55.807	81.713	0.456
htrA	Streptococcus pneumoniae Rx1	55.807	81.713	0.456
htrA	Streptococcus pneumoniae D39	55.807	81.713	0.456
htrA	Streptococcus pneumoniae R6	55.807	81.713	0.456