Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   K6973_RS08625 Genome accession   NZ_CP082206
Coordinates   1714335..1716230 (-) Length   631 a.a.
NCBI ID   WP_003052158.1    Uniprot ID   A0AAE9ULB9
Organism   Streptococcus dysgalactiae strain DY107     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1709335..1721230
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6973_RS08600 (K6973_08600) - 1710085..1710444 (-) 360 WP_138126236.1 S1 RNA-binding domain-containing protein -
  K6973_RS08605 (K6973_08605) - 1710444..1711844 (-) 1401 WP_222819251.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  K6973_RS08610 (K6973_08610) - 1711881..1712522 (-) 642 WP_014612503.1 response regulator transcription factor -
  K6973_RS08615 (K6973_08615) - 1712515..1713519 (-) 1005 WP_003061197.1 sensor histidine kinase -
  K6973_RS08620 (K6973_08620) liaF 1713516..1714208 (-) 693 WP_015057977.1 cell wall-active antibiotics response protein LiaF -
  K6973_RS08625 (K6973_08625) pknB 1714335..1716230 (-) 1896 WP_003052158.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  K6973_RS08630 (K6973_08630) - 1716227..1716967 (-) 741 WP_003061786.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  K6973_RS08635 (K6973_08635) rsmB 1717005..1718327 (-) 1323 WP_138126991.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  K6973_RS08640 (K6973_08640) fmt 1718317..1719252 (-) 936 WP_138126242.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68741.11 Da        Isoelectric Point: 7.2906

>NTDB_id=600118 K6973_RS08625 WP_003052158.1 1714335..1716230(-) (pknB) [Streptococcus dysgalactiae strain DY107]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPVTTPKVAPTPVTSTTESRL
EHTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPNVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPPTGTAKRKGSAITVYLSIGNKGFEMENYKGIDYQEAMASLMETYGVPKSKIKIERIVTNEYTEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYTYADAVNTLTALGIEASRIKAYAPSSSSATGFVQVNSPSSK
AIVSGQTPYYGTTLSLSEKGEISLYLYPEETHSSSSSTSSEASSSSSSTNDGTGTSSNTELSPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=600118 K6973_RS08625 WP_003052158.1 1714335..1716230(-) (pknB) [Streptococcus dysgalactiae strain DY107]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGCATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATCTAATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTACGTACCAATTATCAGACAGATCAGGTAG
CGGTTGCCCGTTTCCAACGGGAAGCGCGTGCCATGGCTGAGTTAAACCATCCTAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATACGTAGATGGCGCTGACTTAAAGAAGTATATTCAAGATCATGCTCC
TCTATCCAATAATGAAGTGGTCAGAATCATGGAAGAGGTGCTTTCTGCCATGACATTAGCTCACCAGAAAGGGATTGTTC
ATAGAGATTTAAAACCTCAAAACATTCTTTTAACTAAAAATGGTGTGGTTAAGGTAACTGATTTTGGGATTGCCGTTGCT
TTTGCGGAAACGAGTTTGACTCAAACCAACTCTATGTTGGGAAGTGTCCATTACCTATCACCTGAGCAGGCTCGCGGCTC
AAAAGCGACCATTCAAAGTGATATTTATGCGATGGGAATTATGCTCTTTGAAATGTTGACAGGACATATCCCTTATGATG
GCGATAGTGCTGTTACCATTGCTTTGCAACATTTCCAAAAGCCTCTTCCGTCTATTATCGACGAAAACCACAATGTACCG
CAAGCTTTAGAGAATGTGGTTATCCGAGCAACAGCTAAGAAATTAAGCGATCGTTACGGATCAACCTTTGAAATGAGTCG
TGATCTGATGACGGCTCTCAGTTACAACCGGAGTCGTGAACGGAAAGTTATTTTTGATGATGTGGAAAGCACAAAACCTC
TCCCTAAAGTAACACCGGCACCAGTAACGACGCCAAAAGTAGCTCCAACTCCTGTTACGTCCACAACTGAAAGTCGTTTA
GAACACACTAATCAGATGGATACACTCCAGAAACCACAAAAAAAGAAGCGAAATGGTCGTTTCTTGGGTACTTTGTTAAA
AATCCTCTTTTCTCTCTTTATTGTAGGTGTGGCTCTCTTCACTTACTTGGTGCTAACAAAACCTACCTCAGTAAAAGTTC
CTAATGTGACAGGTGTCAGTCTTAAAGTTGCAAAGCAGGAACTGCAAGATTTAGGCTTGAAAGTTGGTAAGGTGAGACAG
ATTGAAAGTGATACTGTTGCGGAAGGGAATGTTGTCCGAACAGATCCACCAACGGGAACAGCCAAGCGCAAGGGTTCAGC
TATCACAGTTTACTTGTCAATTGGCAATAAAGGGTTTGAGATGGAAAACTACAAAGGGATTGATTATCAAGAAGCCATGG
CTAGCTTGATGGAAACCTACGGTGTTCCTAAATCGAAGATTAAGATTGAACGAATCGTGACCAATGAATATACGGAAAAT
ACTGTTATTAGCCAATCTCCGAGTGCAGGGGATAAATTTAATCCTAATGGGAAATCTAAAATTACTCTTAGTGTTGCCGT
GAGTGACACAGTCATTATGCCTATGGTAACCGAATATACCTATGCTGATGCAGTAAATACTTTGACAGCATTAGGTATTG
AAGCTTCAAGGATTAAAGCTTATGCTCCAAGCTCAAGTTCAGCAACAGGTTTTGTTCAGGTTAATTCTCCAAGTTCAAAA
GCTATTGTCAGTGGTCAAACCCCTTATTACGGTACCACATTGAGCCTCTCTGAAAAAGGTGAGATAAGCCTTTACCTTTA
CCCAGAAGAAACGCATTCTTCAAGTAGTTCAACCAGTTCTGAGGCAAGTTCTAGCAGTTCCTCAACAAATGATGGAACGG
GAACAAGTAGTAATACTGAATTAAGCCCATCGGAATCAACTGGTCAAACCCCATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(511-587)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(371-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.358

92.868

0.607
  stkP/pknB Streptococcus salivarius strain HSISS4

62.017

94.295

0.585
  stkP Streptococcus pneumoniae TIGR4

58.221

81.933

0.477
  stkP Streptococcus pneumoniae D39

58.027

81.933

0.475
  stkP Streptococcus pneumoniae R6

58.027

81.933

0.475
  stkP Streptococcus pneumoniae Rx1

57.834

81.933

0.474