Detailed information NTG0600094

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: K6973_RS02990
• Genome accession: NZ_CP082206
• Coordinates: 555377..556126 (+)
• Length: 249 a.a.
• NCBI ID: WP_129556053.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae strain DY107
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 550377..561126

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6973_RS02965 (K6973_02965)	-	550428..550835 (+)	408	WP_218655159.1	diacylglycerol kinase	-
K6973_RS02970 (K6973_02970)	era	550956..551852 (+)	897	WP_218655160.1	GTPase Era	-
K6973_RS02975 (K6973_02975)	-	552039..552515 (+)	477	WP_222819555.1	NUDIX domain-containing protein	-
K6973_RS11250	-	552781..553182 (+)	402	WP_261987959.1	hypothetical protein	-
K6973_RS11255	-	553336..553992 (+)	657	WP_261987960.1	hypothetical protein	-
K6973_RS02985 (K6973_02985)	-	554105..554972 (+)	868	Protein_537	IS30 family transposase	-
K6973_RS02990 (K6973_02990)	comE/blpR	555377..556126 (+)	750	WP_129556053.1	response regulator transcription factor	Regulator
K6973_RS02995 (K6973_02995)	-	556127..557461 (+)	1335	WP_222819556.1	GHKL domain-containing protein	-
K6973_RS03000 (K6973_03000)	-	557609..557734 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
K6973_RS03005 (K6973_03005)	-	557825..559188 (-)	1364	Protein_541	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29257.56 Da
• Isoelectric Point: 5.6284

>NTDB_id=600094 K6973_RS02990 WP_129556053.1 555377..556126(+) (comE/blpR) [Streptococcus dysgalactiae strain DY107]
MNIFVLEDDFLQQTRIEKIIYKILTDNKWEINHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=600094 K6973_RS02990 WP_129556053.1 555377..556126(+) (comE/blpR) [Streptococcus dysgalactiae strain DY107]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACAACAAACTAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGAAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAGGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-119)

• LytTr DNA-binding domain (LytTR) (150-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.328	97.992	0.542
comE/comE1	Streptococcus equinus JB1	42.857	95.582	0.41
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE2	Streptococcus equinus JB1	41.393	97.992	0.406
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.306	99.598	0.382