NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	K6974_RS01255	Genome accession	NZ_CP082204
Coordinates	232831..233571 (+)	Length	246 a.a.
NCBI ID	WP_024398111.1	Uniprot ID	-
Organism	Streptococcus suis strain FJSM5
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 227831..238571

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6974_RS01230 (K6974_01215)	-	228585..230918 (+)	2334	WP_222336632.1	endonuclease MutS2	-
K6974_RS01235	-	230951..231349 (-)	399	WP_024378071.1	hypothetical protein	-
K6974_RS01240 (K6974_01225)	-	231573..231800 (+)	228	WP_222336631.1	ComC/BlpC family peptide pheromone/bacteriocin	-
K6974_RS01245 (K6974_01230)	-	231781..232086 (+)	306	WP_222336630.1	hypothetical protein	-
K6974_RS01250 (K6974_01235)	-	232490..232831 (+)	342	WP_024398112.1	LytTR family DNA-binding domain-containing protein	-
K6974_RS01255 (K6974_01240)	comE/blpR	232831..233571 (+)	741	WP_024398111.1	response regulator transcription factor	Regulator
K6974_RS01260 (K6974_01245)	-	233581..234912 (+)	1332	WP_044773740.1	sensor histidine kinase	-
K6974_RS01265 (K6974_01250)	-	235107..235256 (-)	150	WP_172034621.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
K6974_RS01270 (K6974_01255)	-	235354..236715 (-)	1362	WP_222336629.1	bacteriocin secretion accessory protein	-

Sequence

Protein

Download Length: 246 a.a. Molecular weight: 28789.89 Da Isoelectric Point: 6.8329

                                >NTDB_id=599977 K6974_RS01255 WP_024398111.1 232831..233571(+) (comE/blpR) [Streptococcus suis strain FJSM5]

MNVFVLEDDFAQQSRIESIVGSLMERHHIQTKKFEVFGKPDQLIQAVEEKGTHQLFFLDIEIRADDKKGLEVAQQIRDID

PFAIIVFVTTHSEYMPLAFRYQVSALDFIDKELAPTEFEARLETALLYANGKNSRTVAEDSFYYKSRYAQVQVPFADILY

IETSPHPHRVILHTEKDRLEFTGNLADILKQEKRLLQCHRSYLVNPNNVVKVDRQMKVLYFRNGSNCYVARNRMELVHNA

IRDLHR

Nucleotide

Download Length: 741 bp

                                >NTDB_id=599977 K6974_RS01255 WP_024398111.1 232831..233571(+) (comE/blpR) [Streptococcus suis strain FJSM5]

ATGAATGTATTTGTTTTAGAAGATGATTTTGCCCAACAGTCACGGATTGAGTCAATCGTTGGTAGCTTAATGGAGCGACA

CCACATTCAGACCAAGAAGTTTGAAGTTTTTGGGAAACCAGACCAGTTGATTCAGGCAGTAGAGGAAAAAGGAACTCATC

AACTCTTTTTCTTGGACATTGAGATTCGAGCAGATGACAAGAAGGGGTTAGAGGTGGCTCAACAGATTCGTGATATTGAT

CCCTTTGCCATTATTGTTTTTGTCACCACTCACTCCGAGTATATGCCTCTAGCCTTTCGTTATCAGGTATCGGCTCTGGA

TTTTATTGATAAGGAGCTAGCCCCGACCGAGTTTGAGGCACGGCTTGAGACAGCTCTCCTTTATGCTAATGGGAAAAATA

GTCGGACGGTGGCAGAGGATTCCTTCTATTACAAGTCGCGTTATGCCCAGGTACAAGTACCCTTTGCGGATATTCTCTAT

ATCGAAACATCTCCTCATCCCCATCGGGTTATTCTGCATACGGAGAAGGATCGCTTAGAGTTTACAGGGAATTTGGCAGA

TATTTTGAAACAAGAAAAAAGACTGCTCCAGTGTCATCGCTCTTACTTGGTCAACCCCAATAATGTGGTCAAGGTTGATC

GACAGATGAAAGTTCTCTACTTCCGAAATGGCAGCAACTGCTATGTCGCTCGGAATCGAATGGAGCTAGTTCATAATGCC

ATTCGAGACTTGCATAGATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(3-122)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	51.807	100	0.524
comE/comE1	Streptococcus equinus JB1	43.802	98.374	0.431
comE/comE2	Streptococcus equinus JB1	38.115	99.187	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.398	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.398	100	0.374

Detailed information NTG0599977