NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	KFZ57_RS02270	Genome accession	NZ_CP098229
Coordinates	473626..474750 (+)	Length	374 a.a.
NCBI ID	WP_000228535.1	Uniprot ID	B7LHY7
Organism	Escherichia coli strain XJ55
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 468626..479750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KFZ57_RS02245 (KFZ57_02245)	mscL	468752..469162 (-)	411	WP_000022439.1	large-conductance mechanosensitive channel protein MscL	-
KFZ57_RS02250 (KFZ57_02250)	trkA	469292..470668 (-)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
KFZ57_RS02255 (KFZ57_02255)	rsmB	470690..471979 (-)	1290	WP_096943226.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
KFZ57_RS02260 (KFZ57_02260)	fmt	472025..472972 (-)	948	WP_000004454.1	methionyl-tRNA formyltransferase	-
KFZ57_RS02265 (KFZ57_02265)	def	472987..473496 (-)	510	WP_000114984.1	peptide deformylase	-
KFZ57_RS02270 (KFZ57_02270)	dprA	473626..474750 (+)	1125	WP_000228535.1	DNA-protecting protein DprA	Machinery gene
KFZ57_RS02275 (KFZ57_02275)	smg	474722..475195 (+)	474	WP_000460672.1	DUF494 family protein Smg	-
KFZ57_RS02280 (KFZ57_02280)	yrdD	475224..475766 (+)	543	WP_001129719.1	type I DNA topoisomerase	-
KFZ57_RS02285 (KFZ57_02285)	tsaC	475771..476343 (+)	573	WP_001297709.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
KFZ57_RS02290 (KFZ57_02290)	aroE	476348..477166 (+)	819	WP_089569840.1	shikimate dehydrogenase	-
KFZ57_RS02295 (KFZ57_02295)	yrdB	477163..477420 (+)	258	WP_001070563.1	DUF1488 domain-containing protein	-
KFZ57_RS02300 (KFZ57_02300)	yrdA	477396..477950 (-)	555	WP_001286216.1	gamma carbonic anhydrase family protein	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40954.92 Da Isoelectric Point: 6.3122

                                >NTDB_id=598637 KFZ57_RS02270 WP_000228535.1 473626..474750(+) (dprA) [Escherichia coli strain XJ55]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSQIDAVGLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLVTTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHARLAASLLEHGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQQDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=598637 KFZ57_RS02270 WP_000228535.1 473626..474750(+) (dprA) [Escherichia coli strain XJ55]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGTATCAGCAGCTTGTACGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCAAATTGATGCGGTTGGATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGTGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGCTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGGTTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTCAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCCCGACTGGCTGCCAGTCTGCT

TGAACATGGCGGAGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAAGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCCTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGCAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterProScan.

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

DprA winged helix domain (WHD_DprA)

(312-357)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	B7LHY7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.509	98.663	0.479
dprA	Vibrio cholerae O1 biovar El Tor strain E7946	44.865	98.93	0.444
dprA	Vibrio cholerae strain A1552	44.865	98.93	0.444
dprA	Haemophilus influenzae Rd KW20	45.401	90.107	0.409
dprA	Glaesserella parasuis strain SC1401	44.838	90.642	0.406
dprA	Legionella pneumophila strain ERS1305867	44.545	88.235	0.393

Detailed information NTG0598637