Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   K4752_RS12645 Genome accession   NZ_CP081505
Coordinates   2583431..2584729 (+) Length   432 a.a.
NCBI ID   WP_002368406.1    Uniprot ID   R3K7C6
Organism   Enterococcus faecalis strain E006xJH2-2-TC1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2578431..2589729
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K4752_RS14880 - 2578860..2579036 (-) 177 Protein_2467 IS5/IS1182 family transposase -
  K4752_RS12625 (K4752_12625) - 2579167..2580201 (-) 1035 WP_002388592.1 HEPN domain-containing protein -
  K4752_RS12630 (K4752_12630) - 2580204..2581373 (-) 1170 WP_010774065.1 DUF262 domain-containing protein -
  K4752_RS12635 (K4752_12635) - 2581410..2582369 (-) 960 WP_010774034.1 IS30-like element IS6770 family transposase -
  K4752_RS12640 (K4752_12640) rlmH 2582551..2583030 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  K4752_RS12645 (K4752_12645) htrA 2583431..2584729 (+) 1299 WP_002368406.1 S1C family serine protease Regulator
  K4752_RS12650 (K4752_12650) ytpR 2584776..2585396 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  K4752_RS12655 (K4752_12655) - 2585500..2586324 (-) 825 WP_002385250.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  K4752_RS12660 (K4752_12660) - 2586308..2587078 (-) 771 WP_002365320.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
  K4752_RS12665 (K4752_12665) - 2587100..2587573 (-) 474 WP_002359087.1 PTS sugar transporter subunit IIB -
  K4752_RS12670 (K4752_12670) - 2587576..2588319 (-) 744 WP_002359086.1 BtpA/SgcQ family protein -
  K4752_RS12675 (K4752_12675) - 2588331..2588741 (-) 411 WP_002359084.1 PTS sugar transporter subunit IIA -
  K4752_RS12680 (K4752_12680) - 2588756..2589487 (-) 732 WP_002365323.1 GntR family transcriptional regulator -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44831.95 Da        Isoelectric Point: 4.9968

>NTDB_id=597112 K4752_RS12645 WP_002368406.1 2583431..2584729(+) (htrA) [Enterococcus faecalis strain E006xJH2-2-TC1]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=597112 K4752_RS12645 WP_002368406.1 2583431..2584729(+) (htrA) [Enterococcus faecalis strain E006xJH2-2-TC1]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGTGCTCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTGTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCTGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCGCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAATCCGGTGAAACTATCAATATTAATGCCATTCAAACCGATGCTGCCATTAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGCATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R3K7C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456