Detailed information NTG0059581

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: LOCK919_RS12525
• Genome accession: NC_021721
• Coordinates: 2564776..2566968 (-)
• Length: 730 a.a.
• NCBI ID: WP_013246039.1
• Uniprot ID: A0AAP4JKG1
• Organism: Lacticaseibacillus paracasei
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2559776..2571968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LOCK919_RS12495 (LOCK919_2602)	-	2559939..2560223 (-)	285	WP_003580845.1	bacteriocin immunity protein	-
LOCK919_RS12500 (LOCK919_2603)	-	2560416..2560712 (-)	297	WP_013246034.1	bacteriocin immunity protein	-
LOCK919_RS12505 (LOCK919_2604)	-	2560817..2562172 (-)	1356	WP_013246035.1	threonine/serine ThrE exporter family protein	-
LOCK919_RS12510 (LOCK919_2605)	-	2562478..2562789 (-)	312	WP_013246036.1	hypothetical protein	-
LOCK919_RS12515 (LOCK919_2606)	-	2562862..2563212 (-)	351	WP_013246037.1	hypothetical protein	-
LOCK919_RS12520 (LOCK919_2607)	-	2563386..2564765 (-)	1380	WP_013246038.1	bacteriocin secretion accessory protein	-
LOCK919_RS12525 (LOCK919_2608)	comA	2564776..2566968 (-)	2193	WP_013246039.1	peptide cleavage/export ABC transporter	Regulator
LOCK919_RS17050 (LOCK919_2609)	-	2567256..2567411 (-)	156	WP_013246040.1	bacteriocin-like peptide, LSEI_2386 family	-
LOCK919_RS12530 (LOCK919_2610)	-	2567581..2568879 (+)	1299	WP_013246041.1	GHKL domain-containing protein	-
LOCK919_RS12535 (LOCK919_2611)	-	2568884..2569690 (+)	807	WP_013246042.1	LytR/AlgR family response regulator transcription factor	-
LOCK919_RS12540	-	2569992..2570414 (-)	423	WP_032800967.1	hypothetical protein	-
LOCK919_RS12545 (LOCK919_2612)	-	2570591..2570773 (-)	183	WP_020751751.1	hypothetical protein	-
LOCK919_RS12550 (LOCK919_2613)	-	2571081..2571260 (-)	180	WP_013246044.1	bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81300.54 Da
• Isoelectric Point: 7.0226

>NTDB_id=59581 LOCK919_RS12525 WP_013246039.1 2564776..2566968(-) (comA) [Lacticaseibacillus paracasei]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKDRFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIATGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=59581 LOCK919_RS12525 WP_013246039.1 2564776..2566968(-) (comA) [Lacticaseibacillus paracasei]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTAGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATATTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGATCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCACCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCACTGGTCTCATCCTTGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACTTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCTATCAATGTGACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAGCAAATCAATCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCAATC
AGTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCAGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGACTAGCAATTGCCCGAGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTGACCATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.774	98.356	0.578
comA	Streptococcus pneumoniae Rx1	58.217	98.356	0.573
comA	Streptococcus pneumoniae D39	58.217	98.356	0.573
comA	Streptococcus pneumoniae R6	58.217	98.356	0.573
comA	Streptococcus mitis SK321	58.078	98.356	0.571
comA	Streptococcus pneumoniae TIGR4	57.799	98.356	0.568
comA	Streptococcus gordonii str. Challis substr. CH1	56.964	98.356	0.56
comA/nlmT	Streptococcus mutans UA159	54.848	98.904	0.542