Detailed information NTG0595659

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: M9A05_RS27045
• Genome accession: NZ_CP097575
• Coordinates: 5818824..5819495 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF25
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 5813824..5824495

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M9A05_RS27010 (M9A05_27010)	ppyR	5814291..5814548 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
M9A05_RS27015 (M9A05_27015)	-	5814535..5815734 (+)	1200	WP_017001977.1	NnrS family protein	-
M9A05_RS27020 (M9A05_27020)	-	5815735..5816001 (-)	267	WP_003115326.1	DUF5329 domain-containing protein	-
M9A05_RS27025 (M9A05_27025)	-	5815985..5816878 (-)	894	WP_250177586.1	hypothetical protein	-
M9A05_RS27030 (M9A05_27030)	-	5816905..5817987 (-)	1083	WP_250177587.1	patatin-like phospholipase family protein	-
M9A05_RS27035 (M9A05_27035)	-	5818202..5818510 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
M9A05_RS27040 (M9A05_27040)	-	5818510..5818824 (+)	315	WP_003097704.1	PepSY domain-containing protein	-
M9A05_RS27045 (M9A05_27045)	ciaR	5818824..5819495 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
M9A05_RS27050 (M9A05_27050)	carS	5819492..5820829 (+)	1338	WP_003090493.1	two-component system sensor histidine kinase CarS	-
M9A05_RS27055 (M9A05_27055)	-	5820920..5821228 (+)	309	WP_003116713.1	hypothetical protein	-
M9A05_RS29375	-	5821233..5821769 (-)	537	Protein_5347	methyl-accepting chemotaxis protein	-
M9A05_RS29380	-	5822091..5823377 (-)	1287	Protein_5348	HAMP domain-containing protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=595659 M9A05_RS27045 WP_003090494.1 5818824..5819495(+) (ciaR) [Pseudomonas aeruginosa strain UNC_PaerCF25]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=595659 M9A05_RS27045 WP_003090494.1 5818824..5819495(+) (ciaR) [Pseudomonas aeruginosa strain UNC_PaerCF25]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGATGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGATCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GCTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363