Detailed information
Bioinformatically predicted
Overview
| Name | mecA | Type | Regulator |
| Locus tag | KX728_RS03685 | Genome accession | NZ_CP079724 |
| Coordinates | 735995..736735 (+) | Length | 246 a.a. |
| NCBI ID | WP_215804968.1 | Uniprot ID | - |
| Organism | Streptococcus oralis strain 34 | ||
| Function | degradation of ComW (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 727756..793119 | 735995..736735 | within | 0 |
Gene organization within MGE regions
Location: 727756..793119
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KX728_RS03660 (KX728_03655) | - | 727756..728724 (+) | 969 | WP_215804784.1 | glycosyltransferase family 2 protein | - |
| KX728_RS03665 (KX728_03660) | - | 728746..730905 (+) | 2160 | WP_215804783.1 | LicD family protein | - |
| KX728_RS03670 (KX728_03665) | - | 730963..731775 (+) | 813 | WP_215804782.1 | phosphorylcholine transferase LicD | - |
| KX728_RS03675 (KX728_03670) | - | 731819..734347 (+) | 2529 | WP_215804781.1 | MBL fold metallo-hydrolase | - |
| KX728_RS03680 (KX728_03675) | - | 734394..735872 (-) | 1479 | WP_215804780.1 | oligosaccharide flippase family protein | - |
| KX728_RS03685 (KX728_03680) | mecA | 735995..736735 (+) | 741 | WP_215804968.1 | adaptor protein MecA | Regulator |
| KX728_RS03690 (KX728_03685) | - | 736883..738169 (+) | 1287 | WP_215804779.1 | homoserine dehydrogenase | - |
| KX728_RS03695 (KX728_03690) | thrB | 738171..739040 (+) | 870 | WP_215804778.1 | homoserine kinase | - |
| KX728_RS03700 (KX728_03695) | msrB | 739300..740238 (+) | 939 | WP_215804777.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| KX728_RS03705 (KX728_03700) | - | 740298..742022 (+) | 1725 | WP_215804776.1 | ABC transporter ATP-binding protein | - |
| KX728_RS03710 (KX728_03705) | - | 742024..743772 (+) | 1749 | WP_215804775.1 | ABC transporter ATP-binding protein | - |
| KX728_RS03715 (KX728_03710) | - | 743873..745132 (+) | 1260 | WP_049519552.1 | TRZ/ATZ family protein | - |
| KX728_RS03720 (KX728_03715) | rplJ | 745368..745868 (+) | 501 | WP_001287274.1 | 50S ribosomal protein L10 | - |
| KX728_RS03725 (KX728_03720) | rplL | 745943..746311 (+) | 369 | WP_001196964.1 | 50S ribosomal protein L7/L12 | - |
| KX728_RS09320 | - | 746411..747064 (-) | 654 | WP_223335635.1 | site-specific integrase | - |
| KX728_RS09325 | - | 747253..747561 (-) | 309 | WP_223335634.1 | hypothetical protein | - |
| KX728_RS03735 (KX728_03730) | - | 747685..748539 (-) | 855 | WP_215804774.1 | DNA adenine methylase | - |
| KX728_RS03740 (KX728_03735) | - | 748594..750303 (-) | 1710 | WP_215804773.1 | AAA family ATPase | - |
| KX728_RS03745 (KX728_03740) | - | 750306..750689 (-) | 384 | WP_215804772.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KX728_RS03750 (KX728_03745) | - | 750676..751047 (-) | 372 | WP_215804771.1 | helix-turn-helix domain-containing protein | - |
| KX728_RS03755 (KX728_03750) | - | 751497..752027 (-) | 531 | WP_215804770.1 | hypothetical protein | - |
| KX728_RS03760 (KX728_03755) | - | 752080..752289 (+) | 210 | WP_215804769.1 | helix-turn-helix transcriptional regulator | - |
| KX728_RS03765 (KX728_03760) | - | 752293..752490 (+) | 198 | WP_215804768.1 | hypothetical protein | - |
| KX728_RS09330 | - | 752501..752629 (+) | 129 | WP_257474690.1 | hypothetical protein | - |
| KX728_RS03775 (KX728_03770) | gdhA | 753074..754420 (-) | 1347 | WP_215804767.1 | NADP-specific glutamate dehydrogenase | - |
| KX728_RS03780 (KX728_03775) | - | 754654..755589 (+) | 936 | WP_215804766.1 | dihydroorotate oxidase | - |
| KX728_RS03785 (KX728_03780) | holA | 755623..756660 (+) | 1038 | WP_215804765.1 | DNA polymerase III subunit delta | - |
| KX728_RS03790 (KX728_03785) | sodA | 756730..757335 (+) | 606 | WP_000974725.1 | superoxide dismutase SodA | - |
| KX728_RS03795 (KX728_03790) | - | 757491..758021 (+) | 531 | WP_061406909.1 | YutD family protein | - |
| KX728_RS03800 (KX728_03795) | rlmN | 758042..759127 (+) | 1086 | WP_215804764.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| KX728_RS03805 (KX728_03800) | - | 759129..759617 (+) | 489 | WP_215804763.1 | VanZ family protein | - |
| KX728_RS03810 (KX728_03805) | - | 759614..761155 (+) | 1542 | WP_215804762.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| KX728_RS03815 (KX728_03810) | - | 761198..761437 (-) | 240 | WP_000600215.1 | zinc-ribbon domain-containing protein | - |
| KX728_RS03820 (KX728_03815) | - | 761465..762271 (-) | 807 | WP_045617343.1 | peptidylprolyl isomerase | - |
| KX728_RS03825 (KX728_03820) | rpsP | 762488..762760 (+) | 273 | WP_000268760.1 | 30S ribosomal protein S16 | - |
| KX728_RS03830 (KX728_03825) | kphA | 762780..763019 (+) | 240 | WP_000379625.1 | RNA-binding protein KphA | - |
| KX728_RS03835 (KX728_03830) | - | 763062..763397 (+) | 336 | WP_009013949.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| KX728_RS03840 (KX728_03835) | - | 763471..764022 (+) | 552 | WP_215804761.1 | putative immunity protein | - |
| KX728_RS03845 (KX728_03840) | - | 764152..765054 (+) | 903 | WP_215804760.1 | DMT family transporter | - |
| KX728_RS03850 (KX728_03845) | - | 765204..766061 (+) | 858 | WP_215804759.1 | alpha/beta fold hydrolase | - |
| KX728_RS03855 (KX728_03850) | - | 766160..766948 (+) | 789 | WP_215804758.1 | alpha/beta hydrolase | - |
| KX728_RS03860 (KX728_03855) | rimM | 766979..767497 (+) | 519 | WP_215804757.1 | ribosome maturation factor RimM | - |
| KX728_RS03865 (KX728_03860) | trmD | 767487..768206 (+) | 720 | WP_215804967.1 | tRNA (guanosine(37)-N1)-methyltransferase TrmD | - |
| KX728_RS03870 (KX728_03865) | - | 768218..768556 (+) | 339 | WP_001196045.1 | ATP cone domain-containing protein | - |
| KX728_RS03875 (KX728_03870) | - | 768584..768904 (-) | 321 | WP_215804756.1 | hypothetical protein | - |
| KX728_RS03880 (KX728_03875) | - | 769008..769226 (+) | 219 | WP_084939098.1 | YdbC family protein | - |
| KX728_RS03885 (KX728_03880) | - | 769260..769817 (-) | 558 | WP_215804755.1 | TetR/AcrR family transcriptional regulator | - |
| KX728_RS03890 (KX728_03885) | - | 770210..770746 (-) | 537 | WP_042768991.1 | biotin transporter BioY | - |
| KX728_RS03895 (KX728_03890) | gor | 770890..772236 (-) | 1347 | WP_215804754.1 | glutathione-disulfide reductase | - |
| KX728_RS03900 (KX728_03895) | - | 772503..773687 (+) | 1185 | WP_215804753.1 | efflux RND transporter periplasmic adaptor subunit | - |
| KX728_RS03905 (KX728_03900) | - | 773671..774372 (+) | 702 | WP_000733788.1 | ABC transporter ATP-binding protein | - |
| KX728_RS03910 (KX728_03905) | - | 774374..775633 (+) | 1260 | WP_215804752.1 | ABC transporter permease | - |
| KX728_RS03915 (KX728_03910) | metG | 775770..777767 (+) | 1998 | WP_215804751.1 | methionine--tRNA ligase | - |
| KX728_RS03920 (KX728_03915) | - | 777784..778317 (-) | 534 | WP_125328397.1 | DNA topology modulation protein | - |
| KX728_RS03925 (KX728_03920) | rpsT | 778370..778606 (-) | 237 | WP_001274000.1 | 30S ribosomal protein S20 | - |
| KX728_RS03930 (KX728_03925) | coaA | 778674..779594 (-) | 921 | WP_215804750.1 | type I pantothenate kinase | - |
| KX728_RS03935 (KX728_03930) | - | 779796..780200 (+) | 405 | WP_215804749.1 | hypothetical protein | - |
| KX728_RS03940 (KX728_03935) | - | 780403..780993 (+) | 591 | WP_215804748.1 | class I SAM-dependent methyltransferase | - |
| KX728_RS03945 (KX728_03940) | - | 780990..782267 (+) | 1278 | WP_215804747.1 | pyrimidine-nucleoside phosphorylase | - |
| KX728_RS03950 (KX728_03945) | deoC | 782287..782949 (+) | 663 | WP_215804746.1 | deoxyribose-phosphate aldolase | - |
| KX728_RS03955 (KX728_03950) | - | 782936..783325 (+) | 390 | WP_000246111.1 | cytidine deaminase | - |
| KX728_RS03960 (KX728_03955) | - | 783415..784470 (+) | 1056 | WP_049477645.1 | BMP family protein | - |
| KX728_RS03965 (KX728_03960) | - | 784607..786142 (+) | 1536 | WP_219108679.1 | ABC transporter ATP-binding protein | - |
| KX728_RS03970 (KX728_03965) | - | 786135..787193 (+) | 1059 | WP_000038688.1 | ABC transporter permease | - |
| KX728_RS03975 (KX728_03970) | - | 787196..788151 (+) | 956 | Protein_740 | ABC transporter permease | - |
| KX728_RS03980 (KX728_03975) | plsY | 788186..788827 (-) | 642 | WP_049550356.1 | glycerol-3-phosphate 1-O-acyltransferase PlsY | - |
| KX728_RS03985 (KX728_03980) | parE | 788963..790906 (+) | 1944 | WP_000037293.1 | DNA topoisomerase IV subunit B | - |
| KX728_RS03990 (KX728_03985) | - | 791769..792281 (+) | 513 | WP_049484235.1 | hypothetical protein | - |
| KX728_RS03995 (KX728_03990) | - | 792271..793119 (+) | 849 | WP_215804744.1 | aminoglycoside 6-adenylyltransferase | - |
Sequence
Protein
Download Length: 246 a.a. Molecular weight: 28484.30 Da Isoelectric Point: 4.1097
>NTDB_id=588972 KX728_RS03685 WP_215804968.1 735995..736735(+) (mecA) [Streptococcus oralis strain 34]
MKMKQISDTTLKITMTLDDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKI
DQTLDFEDLADLPDMEELAQMSPDEFLKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQADKETESKKEPYIYYILRFA
SLADLVAFAKTVNYQMETSELYKMNGHYYLTILVDVENHPSPYPAWLLARMREFADDSDISRSVLQEYGQILINHDAVLG
LQKIRS
MKMKQISDTTLKITMTLDDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKI
DQTLDFEDLADLPDMEELAQMSPDEFLKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQADKETESKKEPYIYYILRFA
SLADLVAFAKTVNYQMETSELYKMNGHYYLTILVDVENHPSPYPAWLLARMREFADDSDISRSVLQEYGQILINHDAVLG
LQKIRS
Nucleotide
Download Length: 741 bp
>NTDB_id=588972 KX728_RS03685 WP_215804968.1 735995..736735(+) (mecA) [Streptococcus oralis strain 34]
ATGAAGATGAAACAAATTAGTGATACAACACTGAAAATCACGATGACTTTAGATGATTTGATGGATAGAGGAATGGAGAT
TGCAGACTTTCTCGTTCCTCAGGAAAAAACCGAAGAGTTTTTCTATGCTATTTTAGATGAGTTAGAGATGCCAGACAATT
TCTTGGATAGTGGTATGCTGAGTTTCCGCGTGACGCCAAAACCTGATAAGGTGGACGTCTTTGTGACCAAATCCAAGATT
GACCAAACTCTGGATTTTGAAGATTTGGCGGATCTACCAGACATGGAAGAATTAGCCCAAATGTCGCCAGATGAATTTCT
CAAAACCTTGGAAAAGAGTATTGCAGATAAAACCAAGGACGATATTGAGGCCATCCAATCTCTAGAGCAGGTCGAAGCAA
AGGAAGAAGAGCAAGAGCAGGCAGACAAGGAGACTGAGAGTAAGAAAGAACCTTATATCTACTATATCCTGCGCTTTGCA
AGCCTTGCTGACTTAGTTGCTTTTGCAAAGACGGTTAACTACCAGATGGAAACATCTGAACTCTATAAGATGAATGGACA
CTATTATTTGACAATCTTAGTCGATGTGGAAAATCATCCAAGTCCATATCCGGCTTGGCTCTTGGCTCGTATGCGTGAGT
TTGCAGACGACAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGGCAAATATTGATTAACCATGACGCAGTTCTCGGT
CTGCAAAAGATTCGTTCATAA
ATGAAGATGAAACAAATTAGTGATACAACACTGAAAATCACGATGACTTTAGATGATTTGATGGATAGAGGAATGGAGAT
TGCAGACTTTCTCGTTCCTCAGGAAAAAACCGAAGAGTTTTTCTATGCTATTTTAGATGAGTTAGAGATGCCAGACAATT
TCTTGGATAGTGGTATGCTGAGTTTCCGCGTGACGCCAAAACCTGATAAGGTGGACGTCTTTGTGACCAAATCCAAGATT
GACCAAACTCTGGATTTTGAAGATTTGGCGGATCTACCAGACATGGAAGAATTAGCCCAAATGTCGCCAGATGAATTTCT
CAAAACCTTGGAAAAGAGTATTGCAGATAAAACCAAGGACGATATTGAGGCCATCCAATCTCTAGAGCAGGTCGAAGCAA
AGGAAGAAGAGCAAGAGCAGGCAGACAAGGAGACTGAGAGTAAGAAAGAACCTTATATCTACTATATCCTGCGCTTTGCA
AGCCTTGCTGACTTAGTTGCTTTTGCAAAGACGGTTAACTACCAGATGGAAACATCTGAACTCTATAAGATGAATGGACA
CTATTATTTGACAATCTTAGTCGATGTGGAAAATCATCCAAGTCCATATCCGGCTTGGCTCTTGGCTCGTATGCGTGAGT
TTGCAGACGACAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGGCAAATATTGATTAACCATGACGCAGTTCTCGGT
CTGCAAAAGATTCGTTCATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| mecA | Streptococcus pneumoniae Rx1 |
90.574 |
99.187 |
0.898 |
| mecA | Streptococcus pneumoniae D39 |
90.574 |
99.187 |
0.898 |
| mecA | Streptococcus pneumoniae R6 |
90.574 |
99.187 |
0.898 |
| mecA | Streptococcus pneumoniae TIGR4 |
90.164 |
99.187 |
0.894 |
| mecA | Streptococcus thermophilus LMD-9 |
47.222 |
100 |
0.484 |
| mecA | Streptococcus thermophilus LMG 18311 |
47.222 |
100 |
0.484 |
| mecA | Streptococcus mutans UA159 |
47.951 |
99.187 |
0.476 |