Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   MDRSPN_RS03855 Genome accession   NZ_AP018391
Coordinates   734114..734851 (+) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   C1CQZ3
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 729114..739851
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS03840 (MDRSPN_00721) - 730039..731472 (+) 1434 WP_120164196.1 O-antigen polysaccharide polymerase Wzy family protein -
  MDRSPN_RS03845 (MDRSPN_00722) - 731501..732535 (+) 1035 WP_000461502.1 hypothetical protein -
  MDRSPN_RS03850 (MDRSPN_00723) - 732628..733884 (-) 1257 WP_120164197.1 ISL3 family transposase -
  MDRSPN_RS03855 (MDRSPN_00724) mecA 734114..734851 (+) 738 WP_000782676.1 adaptor protein MecA Regulator
  MDRSPN_RS03860 (MDRSPN_00725) - 735002..736288 (+) 1287 WP_000216382.1 homoserine dehydrogenase -
  MDRSPN_RS03865 (MDRSPN_00726) thrB 736290..737159 (+) 870 WP_000692432.1 homoserine kinase -
  MDRSPN_RS11225 - 737235..737387 (+) 153 WP_001835993.1 hypothetical protein -
  MDRSPN_RS03875 (MDRSPN_00727) msrB 737454..738392 (+) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=58520 MDRSPN_RS03855 WP_000782676.1 734114..734851(+) (mecA) [Streptococcus pneumoniae strain MDRSPN001]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=58520 MDRSPN_RS03855 WP_000782676.1 734114..734851(+) (mecA) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GATCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTAACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CQZ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482