Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   VB13_RS01345 Genome accession   NZ_CP077685
Coordinates   249399..250160 (+) Length   253 a.a.
NCBI ID   WP_009880576.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain M49 591     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 244399..255160
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VB13_RS01330 (VB13_01385) - 244657..246225 (-) 1569 WP_109821085.1 ABC transporter substrate-binding protein/permease -
  VB13_RS01335 (VB13_01390) - 246423..248348 (+) 1926 WP_136040326.1 DUF2207 domain-containing protein -
  VB13_RS01340 (VB13_01395) - 248414..249253 (+) 840 WP_009880575.1 undecaprenyl-diphosphate phosphatase -
  VB13_RS01345 (VB13_01400) mecA 249399..250160 (+) 762 WP_009880576.1 adaptor protein MecA Regulator
  VB13_RS01350 (VB13_01405) - 250167..251336 (+) 1170 WP_012560443.1 glycosyltransferase family 4 protein -
  VB13_RS01355 (VB13_01410) sufC 251458..252228 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  VB13_RS01360 (VB13_01415) sufD 252323..253585 (+) 1263 WP_009880578.1 Fe-S cluster assembly protein SufD -
  VB13_RS01365 (VB13_01420) - 253616..254842 (+) 1227 WP_012560444.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29039.67 Da        Isoelectric Point: 4.1622

>NTDB_id=582221 VB13_RS01345 WP_009880576.1 249399..250160(+) (mecA) [Streptococcus pyogenes strain M49 591]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSTEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=582221 VB13_RS01345 WP_009880576.1 249399..250160(+) (mecA) [Streptococcus pyogenes strain M49 591]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTAGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCTACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGACAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486