Detailed information NTG0058174

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: SPN034183_RS05935
• Genome accession: NC_021028
• Coordinates: 1122010..1122714 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae SPN034183
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1117010..1127714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN034183_RS05905 (SPN034183_10910)	-	1117191..1118177 (+)	987	WP_000204733.1	L-lactate dehydrogenase	-
SPN034183_RS05910 (SPN034183_10920)	-	1118478..1119221 (-)	744	Protein_1140	ion channel	-
SPN034183_RS05915 (SPN034183_10930)	-	1119268..1119522 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SPN034183_RS05920 (SPN034183_10940)	-	1119524..1119766 (-)	243	WP_000208080.1	DUF6290 family protein	-
SPN034183_RS05925 (SPN034183_10950)	vicX	1119857..1120666 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
SPN034183_RS05930 (SPN034183_10960)	micB	1120668..1122017 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPN034183_RS05935 (SPN034183_10970)	micA	1122010..1122714 (-)	705	WP_000722076.1	response regulator YycF	Regulator
SPN034183_RS05940 (SPN034183_10980)	mutY	1122769..1123944 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
SPN034183_RS05945 (SPN034183_10990)	-	1124273..1125943 (-)	1671	WP_000845287.1	formate--tetrahydrofolate ligase	-
SPN034183_RS05950 (SPN034183_11000)	coaB	1126173..1126862 (+)	690	WP_000699489.1	phosphopantothenate--cysteine ligase	-
SPN034183_RS05955 (SPN034183_11010)	coaC	1126874..1127425 (+)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=58174 SPN034183_RS05935 WP_000722076.1 1122010..1122714(-) (micA) [Streptococcus pneumoniae SPN034183]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=58174 SPN034183_RS05935 WP_000722076.1 1122010..1122714(-) (micA) [Streptococcus pneumoniae SPN034183]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38