Detailed information
Bioinformatically predicted
Overview
| Name | comB | Type | Regulator |
| Locus tag | SPN034183_RS00485 | Genome accession | NC_021028 |
| Coordinates | 76577..77926 (+) | Length | 449 a.a. |
| NCBI ID | WP_000801618.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae SPN034183 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12359..88031 | 76577..77926 | within | 0 |
Gene organization within MGE regions
Location: 12359..88031
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SPN034183_RS00065 (SPN034183_00130) | ftsH | 12359..14317 (+) | 1959 | WP_000744554.1 | ATP-dependent zinc metalloprotease FtsH | - |
| SPN034183_RS00070 (SPN034183_00140) | comX/comX2 | 14439..14918 (+) | 480 | WP_000588866.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| SPN034183_RS00105 | - | 20468..20677 (+) | 210 | Protein_14 | transposase | - |
| SPN034183_RS11050 (SPN034183_00150) | - | 20712..21509 (-) | 798 | Protein_15 | transposase | - |
| SPN034183_RS00125 (SPN034183_00160) | comW | 21775..22011 (+) | 237 | WP_000939546.1 | sigma(X)-activator ComW | Regulator |
| SPN034183_RS00130 (SPN034183_00170) | - | 22242..23528 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| SPN034183_RS00135 (SPN034183_00180) | - | 23770..24918 (-) | 1149 | WP_000876732.1 | site-specific integrase | - |
| SPN034183_RS00140 (SPN034183_00190) | - | 25104..26027 (-) | 924 | WP_000122591.1 | exonuclease domain-containing protein | - |
| SPN034183_RS00145 (SPN034183_00200) | - | 26040..26423 (-) | 384 | WP_000136459.1 | ImmA/IrrE family metallo-endopeptidase | - |
| SPN034183_RS00150 (SPN034183_00210) | - | 26436..26801 (-) | 366 | WP_000492031.1 | helix-turn-helix transcriptional regulator | - |
| SPN034183_RS00155 (SPN034183_00230) | - | 27178..27399 (-) | 222 | WP_000041097.1 | hypothetical protein | - |
| SPN034183_RS12630 (SPN034183_00240) | - | 27518..27664 (+) | 147 | WP_000389576.1 | hypothetical protein | - |
| SPN034183_RS00160 (SPN034183_00250) | - | 27676..27879 (+) | 204 | WP_000032097.1 | helix-turn-helix transcriptional regulator | - |
| SPN034183_RS00165 | - | 27896..28093 (+) | 198 | WP_001057654.1 | hypothetical protein | - |
| SPN034183_RS12635 (SPN034183_00260) | - | 28104..28265 (+) | 162 | WP_001002946.1 | hypothetical protein | - |
| SPN034183_RS00170 (SPN034183_00270) | - | 28260..28685 (-) | 426 | WP_000386249.1 | hypothetical protein | - |
| SPN034183_RS00175 (SPN034183_00280) | - | 28739..29449 (+) | 711 | WP_001002359.1 | ORF6C domain-containing protein | - |
| SPN034183_RS00180 (SPN034183_00290) | - | 29463..29720 (+) | 258 | WP_000370959.1 | hypothetical protein | - |
| SPN034183_RS00185 (SPN034183_00300) | - | 29806..30126 (+) | 321 | WP_000462824.1 | hypothetical protein | - |
| SPN034183_RS00190 (SPN034183_00310) | - | 30142..30438 (+) | 297 | WP_000391805.1 | hypothetical protein | - |
| SPN034183_RS00195 (SPN034183_00320) | - | 30431..31237 (+) | 807 | WP_001289771.1 | phage replisome organizer N-terminal domain-containing protein | - |
| SPN034183_RS00200 (SPN034183_00340) | - | 31377..32147 (+) | 771 | WP_000228219.1 | ATP-binding protein | - |
| SPN034183_RS13365 | - | 32162..32356 (+) | 195 | WP_000470307.1 | hypothetical protein | - |
| SPN034183_RS00210 (SPN034183_00350) | - | 32356..32574 (+) | 219 | WP_000891962.1 | hypothetical protein | - |
| SPN034183_RS11060 | - | 32956..33054 (+) | 99 | Protein_36 | single-stranded DNA-binding protein | - |
| SPN034183_RS12640 (SPN034183_00370) | - | 33068..33235 (+) | 168 | WP_000233203.1 | hypothetical protein | - |
| SPN034183_RS00225 (SPN034183_00380) | - | 33403..33720 (+) | 318 | WP_000969665.1 | hypothetical protein | - |
| SPN034183_RS12870 | - | 33722..33796 (+) | 75 | Protein_39 | DUF1642 domain-containing protein | - |
| SPN034183_RS00230 (SPN034183_00400) | - | 33973..34374 (+) | 402 | WP_000736390.1 | transcriptional activator | - |
| SPN034183_RS00235 (SPN034183_00410) | - | 34562..35104 (+) | 543 | WP_000397549.1 | site-specific integrase | - |
| SPN034183_RS00240 (SPN034183_00420) | - | 35481..35801 (+) | 321 | WP_000282427.1 | HNH endonuclease | - |
| SPN034183_RS00245 (SPN034183_00430) | - | 35938..36330 (+) | 393 | WP_001118283.1 | P27 family phage terminase small subunit | - |
| SPN034183_RS00250 (SPN034183_00440) | - | 36323..38053 (+) | 1731 | WP_000527299.1 | terminase large subunit | - |
| SPN034183_RS00255 | - | 38061..38279 (+) | 219 | WP_001002923.1 | hypothetical protein | - |
| SPN034183_RS00260 (SPN034183_00460) | - | 38297..39499 (+) | 1203 | WP_000510803.1 | phage portal protein | - |
| SPN034183_RS00265 (SPN034183_00470) | - | 39483..40058 (+) | 576 | WP_001172115.1 | HK97 family phage prohead protease | - |
| SPN034183_RS00270 (SPN034183_00480) | - | 40055..41221 (+) | 1167 | WP_001030357.1 | phage major capsid protein | - |
| SPN034183_RS00275 | - | 41233..41502 (+) | 270 | WP_000262606.1 | hypothetical protein | - |
| SPN034183_RS00280 (SPN034183_00500) | - | 41505..41786 (+) | 282 | WP_000370976.1 | hypothetical protein | - |
| SPN034183_RS00285 (SPN034183_00510) | - | 41773..42072 (+) | 300 | WP_000267055.1 | phage head closure protein | - |
| SPN034183_RS00290 (SPN034183_00520) | - | 42069..42416 (+) | 348 | WP_000063886.1 | HK97 gp10 family phage protein | - |
| SPN034183_RS00295 (SPN034183_00530) | - | 42413..42736 (+) | 324 | WP_000777003.1 | hypothetical protein | - |
| SPN034183_RS00300 (SPN034183_00540) | - | 42748..43326 (+) | 579 | WP_000191279.1 | major tail protein | - |
| SPN034183_RS00305 (SPN034183_00550) | - | 43338..43757 (+) | 420 | WP_001227146.1 | hypothetical protein | - |
| SPN034183_RS00310 (SPN034183_00560) | - | 44035..47130 (+) | 3096 | WP_000918318.1 | hypothetical protein | - |
| SPN034183_RS00315 (SPN034183_00570) | - | 47127..47849 (+) | 723 | WP_000589856.1 | hypothetical protein | - |
| SPN034183_RS12400 (SPN034183_00580) | - | 47850..54482 (+) | 6633 | WP_000966215.1 | phage tail spike protein | - |
| SPN034183_RS13370 (SPN034183_00590) | - | 54479..54595 (+) | 117 | WP_001063632.1 | hypothetical protein | - |
| SPN034183_RS00330 (SPN034183_00600) | - | 54576..54779 (+) | 204 | WP_001091113.1 | hypothetical protein | - |
| SPN034183_RS00335 (SPN034183_00610) | - | 54782..55132 (+) | 351 | WP_000852241.1 | hypothetical protein | - |
| SPN034183_RS00340 (SPN034183_00620) | - | 55141..55557 (+) | 417 | WP_001165344.1 | phage holin family protein | - |
| SPN034183_RS00345 (SPN034183_00630) | - | 55561..55893 (+) | 333 | WP_001186219.1 | phage holin | - |
| SPN034183_RS00350 (SPN034183_00640) | - | 55897..56853 (+) | 957 | WP_000350505.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| SPN034183_RS00360 | - | 57074..57262 (-) | 189 | WP_000109850.1 | hypothetical protein | - |
| SPN034183_RS00365 (SPN034183_00670) | tadA | 57830..58297 (+) | 468 | WP_000291870.1 | tRNA adenosine(34) deaminase TadA | - |
| SPN034183_RS00370 (SPN034183_00680) | - | 58483..58926 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| SPN034183_RS00375 (SPN034183_00690) | - | 58928..59443 (+) | 516 | WP_001838385.1 | histidine phosphatase family protein | - |
| SPN034183_RS00380 (SPN034183_00700) | radA | 59457..60818 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| SPN034183_RS00385 (SPN034183_00710) | - | 60891..61388 (+) | 498 | WP_001809263.1 | carbonic anhydrase | - |
| SPN034183_RS00395 (SPN034183_00720) | - | 61413..62243 (+) | 831 | Protein_71 | PrsW family glutamic-type intramembrane protease | - |
| SPN034183_RS00400 (SPN034183_00730) | - | 62388..63356 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| SPN034183_RS11075 (SPN034183_00740) | - | 63493..63771 (-) | 279 | Protein_73 | transposase family protein | - |
| SPN034183_RS12875 | - | 63815..64740 (-) | 926 | Protein_74 | Rpn family recombination-promoting nuclease/putative transposase | - |
| SPN034183_RS00425 (SPN034183_00770) | polA | 64996..67629 (+) | 2634 | WP_001809267.1 | DNA polymerase I | - |
| SPN034183_RS00430 (SPN034183_00780) | - | 67714..68151 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| SPN034183_RS12880 | - | 68192..68575 (+) | 384 | WP_000693132.1 | hypothetical protein | - |
| SPN034183_RS00440 (SPN034183_00790) | - | 68604..69613 (-) | 1010 | Protein_78 | YeiH family protein | - |
| SPN034183_RS00445 (SPN034183_00800) | - | 69762..70931 (+) | 1170 | WP_000366345.1 | pyridoxal phosphate-dependent aminotransferase | - |
| SPN034183_RS00450 (SPN034183_00810) | recO | 70928..71698 (+) | 771 | WP_000616162.1 | DNA repair protein RecO | - |
| SPN034183_RS00455 (SPN034183_00820) | plsX | 71695..72687 (+) | 993 | WP_000717457.1 | phosphate acyltransferase PlsX | - |
| SPN034183_RS00460 (SPN034183_00830) | - | 72693..72926 (+) | 234 | WP_000659556.1 | acyl carrier protein | - |
| SPN034183_RS11085 (SPN034183_00840) | - | 72972..73263 (+) | 292 | Protein_83 | IS5/IS1182 family transposase | - |
| SPN034183_RS00465 (SPN034183_00850) | blpU | 73466..73696 (+) | 231 | Protein_84 | bacteriocin-like peptide BlpU | - |
| SPN034183_RS13240 (SPN034183_00860) | - | 73699..73824 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| SPN034183_RS00480 (SPN034183_00870) | comA | 74411..76564 (+) | 2154 | WP_000668304.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| SPN034183_RS00485 (SPN034183_00880) | comB | 76577..77926 (+) | 1350 | WP_000801618.1 | competence pheromone export protein ComB | Regulator |
| SPN034183_RS00490 (SPN034183_00890) | purC | 78096..78803 (+) | 708 | WP_000043304.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| SPN034183_RS13375 | - | 78805..78948 (+) | 144 | WP_050167432.1 | hypothetical protein | - |
| SPN034183_RS00495 (SPN034183_00900) | - | 79005..82730 (+) | 3726 | WP_000361178.1 | phosphoribosylformylglycinamidine synthase | - |
| SPN034183_RS00500 (SPN034183_00910) | purF | 82823..84265 (+) | 1443 | WP_000220633.1 | amidophosphoribosyltransferase | - |
| SPN034183_RS00505 (SPN034183_00920) | purM | 84302..85324 (+) | 1023 | WP_000182558.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| SPN034183_RS00510 (SPN034183_00930) | purN | 85321..85866 (+) | 546 | WP_000717506.1 | phosphoribosylglycinamide formyltransferase | - |
| SPN034183_RS00515 (SPN034183_00940) | - | 85950..86459 (+) | 510 | WP_000894018.1 | VanZ family protein | - |
| SPN034183_RS00520 (SPN034183_00950) | purH | 86484..88031 (+) | 1548 | WP_000167082.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 49615.49 Da Isoelectric Point: 5.3895
>NTDB_id=58154 SPN034183_RS00485 WP_000801618.1 76577..77926(+) (comB) [Streptococcus pneumoniae SPN034183]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAMETGASLASQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Nucleotide
Download Length: 1350 bp
>NTDB_id=58154 SPN034183_RS00485 WP_000801618.1 76577..77926(+) (comB) [Streptococcus pneumoniae SPN034183]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATGGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACATTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCAACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATGGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACATTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCAACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB | Streptococcus pneumoniae TIGR4 |
99.109 |
100 |
0.991 |
| comB | Streptococcus pneumoniae Rx1 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae D39 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae R6 |
98.886 |
100 |
0.989 |
| comB | Streptococcus mitis SK321 |
95.1 |
100 |
0.951 |
| comB | Streptococcus mitis NCTC 12261 |
94.655 |
100 |
0.947 |
| comB | Streptococcus gordonii str. Challis substr. CH1 |
55.333 |
100 |
0.555 |