Detailed information NTG0581526

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: JGX27_RS10085
• Genome accession: NZ_CP077423
• Coordinates: 2010489..2011217 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus subsp. gallolyticus TX20005
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2005489..2016217

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JGX27_RS10060 (JGX27_10060)	rsgA	2005713..2006585 (-)	873	WP_009854990.1	ribosome small subunit-dependent GTPase A	-
JGX27_RS10075 (JGX27_10075)	-	2008780..2008980 (-)	201	WP_009854991.1	hypothetical protein	-
JGX27_RS10080 (JGX27_10080)	comD/comD3	2009112..2010476 (-)	1365	WP_009854992.1	GHKL domain-containing protein	Regulator
JGX27_RS10085 (JGX27_10085)	comE/comE2	2010489..2011217 (-)	729	WP_012962512.1	LytTR family DNA-binding domain-containing protein	Regulator
JGX27_RS10090 (JGX27_10090)	-	2011316..2011609 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
JGX27_RS10095 (JGX27_10095)	-	2011660..2011887 (-)	228	WP_009854995.1	hypothetical protein	-
JGX27_RS10100 (JGX27_10100)	-	2012157..2012468 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
JGX27_RS10105 (JGX27_10105)	-	2012480..2012629 (-)	150	WP_009854997.1	hypothetical protein	-
JGX27_RS10110 (JGX27_10110)	-	2012639..2012938 (-)	300	WP_009854998.1	DUF3884 family protein	-
JGX27_RS10115 (JGX27_10115)	-	2013238..2013375 (+)	138	WP_009854999.1	hypothetical protein	-
JGX27_RS10120 (JGX27_10120)	-	2013397..2014704 (-)	1308	WP_009855000.1	GHKL domain-containing protein	-
JGX27_RS10125 (JGX27_10125)	comE/comE1	2014712..2015443 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
JGX27_RS10130 (JGX27_10130)	-	2015460..2015744 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
JGX27_RS10135 (JGX27_10135)	-	2015987..2016187 (-)	201	WP_009855003.1	hypothetical protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=581526 JGX27_RS10085 WP_012962512.1 2010489..2011217(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=581526 JGX27_RS10085 WP_012962512.1 2010489..2011217(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCTAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACCGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACCAAAATCAGAATACCATTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426