Detailed information NTG0581527

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: JGX27_RS10125
• Genome accession: NZ_CP077423
• Coordinates: 2014712..2015443 (-)
• Length: 243 a.a.
• NCBI ID: WP_009855001.1
• Uniprot ID: A0A380K1N3
• Organism: Streptococcus gallolyticus subsp. gallolyticus TX20005
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2009712..2020443

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JGX27_RS10085 (JGX27_10085)	comE/comE2	2010489..2011217 (-)	729	WP_012962512.1	LytTR family DNA-binding domain-containing protein	Regulator
JGX27_RS10090 (JGX27_10090)	-	2011316..2011609 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
JGX27_RS10095 (JGX27_10095)	-	2011660..2011887 (-)	228	WP_009854995.1	hypothetical protein	-
JGX27_RS10100 (JGX27_10100)	-	2012157..2012468 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
JGX27_RS10105 (JGX27_10105)	-	2012480..2012629 (-)	150	WP_009854997.1	hypothetical protein	-
JGX27_RS10110 (JGX27_10110)	-	2012639..2012938 (-)	300	WP_009854998.1	DUF3884 family protein	-
JGX27_RS10115 (JGX27_10115)	-	2013238..2013375 (+)	138	WP_009854999.1	hypothetical protein	-
JGX27_RS10120 (JGX27_10120)	-	2013397..2014704 (-)	1308	WP_009855000.1	GHKL domain-containing protein	-
JGX27_RS10125 (JGX27_10125)	comE/comE1	2014712..2015443 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
JGX27_RS10130 (JGX27_10130)	-	2015460..2015744 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
JGX27_RS10135 (JGX27_10135)	-	2015987..2016187 (-)	201	WP_009855003.1	hypothetical protein	-
JGX27_RS10140 (JGX27_10140)	-	2016509..2017522 (-)	1014	WP_009855005.1	bacteriocin biosynthesis protein	-
JGX27_RS10145 (JGX27_10145)	-	2018580..2018777 (-)	198	WP_009855009.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
JGX27_RS10150 (JGX27_10150)	-	2018796..2019047 (-)	252	WP_009855010.1	bacteriocin class II family protein	-
JGX27_RS10155 (JGX27_10155)	-	2019294..2019551 (+)	258	WP_009855011.1	hypothetical protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28456.61 Da
• Isoelectric Point: 5.4335

>NTDB_id=581527 JGX27_RS10125 WP_009855001.1 2014712..2015443(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus TX20005]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRMPYSDIL
YFETSPAVHRVIMHTKNDRMEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=581527 JGX27_RS10125 WP_009855001.1 2014712..2015443(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAGAACCTGAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTATTTGAAACTCCTAAAGCACGTGTGCGCATGCCATATAGTGACATTCTC
TATTTTGAAACCTCTCCTGCTGTGCACCGCGTGATTATGCATACGAAAAATGACAGAATGGAATTTTATGCAACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTTAAGTGTCATCGTTCTTTTATTATTAATGTGGATAATGTGGTCAGATTTG
ATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACACTTGCCTAGTTTCTAGAGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (11-123)

• LytTr DNA-binding domain (LytTR) (152-238)

3D structure

• AlphaFold DB: A0A380K1N3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	71.605	100	0.716
comE/blpR	Streptococcus mutans UA159	47.699	98.354	0.469
comE/comE2	Streptococcus equinus JB1	46.694	99.588	0.465