Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6L67_RS09175 Genome accession   NZ_CP077320
Coordinates   1943781..1945064 (-) Length   427 a.a.
NCBI ID   WP_005875495.1    Uniprot ID   A0A377L278
Organism   Enterococcus durans strain FDAARGOS 1437     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1938781..1950064
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L67_RS09145 (I6L67_09145) - 1938832..1939800 (-) 969 WP_005875489.1 glycosyltransferase family 2 protein -
  I6L67_RS09150 (I6L67_09150) - 1939981..1940331 (-) 351 WP_016177291.1 PepSY domain-containing protein -
  I6L67_RS09155 (I6L67_09155) pepA 1940529..1941608 (+) 1080 WP_016177292.1 glutamyl aminopeptidase -
  I6L67_RS09160 (I6L67_09160) - 1941913..1942233 (+) 321 WP_005875492.1 thioredoxin family protein -
  I6L67_RS09165 (I6L67_09165) - 1942255..1942719 (+) 465 WP_005875493.1 universal stress protein -
  I6L67_RS09170 (I6L67_09170) ytpR 1943059..1943676 (+) 618 WP_016177293.1 YtpR family tRNA-binding protein -
  I6L67_RS09175 (I6L67_09175) htrA 1943781..1945064 (-) 1284 WP_005875495.1 S1C family serine protease Regulator
  I6L67_RS09180 (I6L67_09180) rlmH 1945492..1945971 (+) 480 WP_005875496.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L67_RS09185 (I6L67_09185) sstT 1946428..1947642 (+) 1215 WP_033624411.1 serine/threonine transporter SstT -
  I6L67_RS09190 (I6L67_09190) - 1947848..1948807 (+) 960 WP_016176468.1 IS30-like element IS6770 family transposase -
  I6L67_RS09195 (I6L67_09195) - 1949250..1949714 (+) 465 WP_060789894.1 PTS sugar transporter subunit IIA -
  I6L67_RS09200 (I6L67_09200) - 1949707..1950003 (+) 297 WP_002290091.1 PTS sugar transporter subunit IIB -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44801.83 Da        Isoelectric Point: 4.5954

>NTDB_id=580809 I6L67_RS09175 WP_005875495.1 1943781..1945064(-) (htrA) [Enterococcus durans strain FDAARGOS 1437]
MDRKDVTSKMKKKNNGLWRKLGLGLVGGVIGGLLTAGIFYAALGNGHSNTSAGGNQNSSGETVVENVKVNVDSDITSAVD
KVQDAVVSVINLQSQNQSNDFGKLFGQQQQSTEDSDLEASSEGSGVIYKKEGNTSYIVTNNHVVDGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKIQSDKVDKVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIVSSLNRQVTSTNESNETVNI
NAIQTDAAINPGNSGGPLINIEGQVIGINSSKIATTSESSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMY
DLSYVSTQQKEQVLKIPSLVTNGVIVASVQPATPAEKAGLKQYDVITKIDDTEVSSGVELQSALYKKKVGDTVKITYYQE
KDEKTATVELTIDQSALKQNQSSNSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=580809 I6L67_RS09175 WP_005875495.1 1943781..1945064(-) (htrA) [Enterococcus durans strain FDAARGOS 1437]
ATGGATAGAAAAGATGTGACATCAAAAATGAAAAAGAAAAATAATGGTCTTTGGCGCAAACTTGGACTAGGTTTAGTCGG
TGGTGTGATTGGAGGATTATTAACAGCGGGTATTTTTTATGCTGCATTAGGAAATGGTCACTCCAATACGAGTGCTGGGG
GTAACCAGAATTCGTCAGGTGAAACTGTTGTAGAAAATGTCAAAGTGAATGTAGATTCAGATATTACTAGTGCTGTAGAT
AAAGTACAAGATGCGGTAGTTTCCGTTATCAACTTGCAAAGTCAAAATCAATCGAACGATTTTGGCAAACTATTTGGGCA
ACAGCAGCAAAGTACTGAAGATAGTGATCTAGAGGCTTCTAGTGAAGGGAGTGGCGTTATCTACAAAAAAGAGGGCAACA
CTTCATATATCGTAACAAATAACCACGTAGTTGATGGGCAACAAGGATTAGAAGTTTTGCTCAAAGATGGGACAAAAGTC
AAAGCAGAATTAGTTGGAACTGATGCTTATTCTGATTTAGCTGTATTGAAGATCCAATCAGATAAAGTGGATAAAGTTGC
TTCTTTTGGCGACTCTAGTGCTTTAAAAGTTGGTGAACCTGCAATTGCAATTGGTTCTCCTTTAGGTTCCGAATATGCCA
ATTCAGTGACATCAGGTATCGTTTCTTCTTTGAACCGACAAGTGACAAGTACAAATGAATCCAACGAAACTGTAAATATC
AATGCAATCCAAACAGATGCTGCAATCAATCCTGGTAACTCAGGTGGTCCACTGATCAACATTGAAGGACAAGTGATTGG
GATCAACTCAAGTAAAATCGCTACTACTTCTGAATCTTCATCTGGCGTAAGTGTTGAAGGTATGGGCTTTGCAATCCCAA
GTAATGATGTAGTCAATATCATCAACCAACTTGAAAAAGATGGTAAAGTGACACGTCCTGCATTAGGAATTACGATGTAC
GATTTATCTTATGTTTCAACGCAGCAAAAAGAACAAGTCTTGAAGATTCCTTCTTTAGTCACAAATGGTGTAATCGTGGC
AAGTGTCCAACCAGCAACACCTGCTGAAAAAGCTGGTTTGAAACAATATGATGTAATTACTAAAATCGACGACACGGAAG
TTTCATCTGGTGTTGAGTTGCAATCAGCTCTTTATAAGAAAAAAGTTGGTGACACAGTAAAAATCACTTATTACCAAGAA
AAAGATGAAAAAACTGCTACAGTTGAATTGACGATCGATCAATCTGCATTAAAACAAAACCAATCATCGAATTCAGGAAA
CTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

Peptidase family M50 (Peptidase_M50)

(8-419)

PDZ domain (PDZ_2)

(313-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A377L278

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.333

94.848

0.506
  htrA Streptococcus mitis NCTC 12261

54.522

90.632

0.494
  htrA Streptococcus mutans UA159

58.611

84.309

0.494
  htrA Streptococcus pneumoniae TIGR4

59.763

79.157

0.473
  htrA Streptococcus pneumoniae R6

59.763

79.157

0.473
  htrA Streptococcus pneumoniae Rx1

59.763

79.157

0.473
  htrA Streptococcus pneumoniae D39

59.763

79.157

0.473