Detailed information
Bioinformatically predicted
Overview
| Name | mecA | Type | Regulator |
| Locus tag | I6L86_RS06745 | Genome accession | NZ_CP077259 |
| Coordinates | 1402703..1403440 (+) | Length | 245 a.a. |
| NCBI ID | WP_000782682.1 | Uniprot ID | A0AAX2L652 |
| Organism | Streptococcus mitis strain FDAARGOS 1456 | ||
| Function | degradation of ComW (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1390060..1445205 | 1402703..1403440 | within | 0 |
Gene organization within MGE regions
Location: 1390060..1445205
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L86_RS06685 (I6L86_06685) | aroC | 1390313..1391479 (+) | 1167 | WP_001269850.1 | chorismate synthase | - |
| I6L86_RS06690 (I6L86_06690) | - | 1391489..1392592 (+) | 1104 | WP_001140859.1 | prephenate dehydrogenase | - |
| I6L86_RS06695 (I6L86_06695) | - | 1392603..1392941 (+) | 339 | WP_000065969.1 | YlbF/YmcA family competence regulator | - |
| I6L86_RS06700 (I6L86_06700) | aroA | 1393033..1394316 (+) | 1284 | WP_004238699.1 | 3-phosphoshikimate 1-carboxyvinyltransferase | - |
| I6L86_RS06705 (I6L86_06705) | - | 1394309..1394785 (+) | 477 | WP_001151349.1 | shikimate kinase | - |
| I6L86_RS06710 (I6L86_06710) | pheA | 1394782..1395630 (+) | 849 | WP_000686445.1 | prephenate dehydratase | - |
| I6L86_RS06715 (I6L86_06715) | - | 1395627..1396937 (+) | 1311 | WP_000032338.1 | LCP family protein | - |
| I6L86_RS06720 (I6L86_06720) | - | 1397058..1397903 (+) | 846 | WP_001061995.1 | LicD family protein | - |
| I6L86_RS06725 (I6L86_06725) | - | 1397893..1398996 (+) | 1104 | WP_000225887.1 | glycosyltransferase | - |
| I6L86_RS06730 (I6L86_06730) | - | 1398998..1399984 (+) | 987 | WP_000446965.1 | glycosyltransferase family 2 protein | - |
| I6L86_RS06735 (I6L86_06735) | - | 1400000..1401469 (+) | 1470 | WP_004238693.1 | O-antigen polysaccharide polymerase Wzy family protein | - |
| I6L86_RS06740 (I6L86_06740) | - | 1401462..1402496 (+) | 1035 | WP_000461491.1 | hypothetical protein | - |
| I6L86_RS06745 (I6L86_06745) | mecA | 1402703..1403440 (+) | 738 | WP_000782682.1 | adaptor protein MecA | Regulator |
| I6L86_RS06750 (I6L86_06750) | - | 1403592..1404878 (+) | 1287 | WP_000216346.1 | homoserine dehydrogenase | - |
| I6L86_RS06755 (I6L86_06755) | thrB | 1404880..1405749 (+) | 870 | WP_000692425.1 | homoserine kinase | - |
| I6L86_RS06760 (I6L86_06760) | msrB | 1405962..1406900 (+) | 939 | WP_000818182.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| I6L86_RS06765 (I6L86_06765) | - | 1406961..1408685 (+) | 1725 | WP_000681728.1 | ABC transporter ATP-binding protein | - |
| I6L86_RS06770 (I6L86_06770) | - | 1408687..1410435 (+) | 1749 | WP_001254284.1 | ABC transporter ATP-binding protein | - |
| I6L86_RS06775 (I6L86_06775) | - | 1410693..1411952 (+) | 1260 | WP_000870440.1 | TRZ/ATZ family protein | - |
| I6L86_RS06780 (I6L86_06780) | rplJ | 1412203..1412703 (+) | 501 | WP_001287267.1 | 50S ribosomal protein L10 | - |
| I6L86_RS06785 (I6L86_06785) | rplL | 1412776..1413144 (+) | 369 | WP_001196965.1 | 50S ribosomal protein L7/L12 | - |
| I6L86_RS06790 (I6L86_06790) | pezA | 1413672..1414148 (+) | 477 | WP_000579609.1 | type II toxin-antitoxin system antitoxin PezA | - |
| I6L86_RS06795 (I6L86_06795) | pezT | 1414148..1414918 (+) | 771 | WP_000405376.1 | type II toxin-antitoxin system toxin PezT | - |
| I6L86_RS06805 (I6L86_06805) | - | 1416575..1417006 (+) | 432 | WP_025169729.1 | hypothetical protein | - |
| I6L86_RS06810 (I6L86_06810) | - | 1417009..1417398 (+) | 390 | Protein_1296 | replication initiation factor domain-containing protein | - |
| I6L86_RS06815 (I6L86_06815) | - | 1417561..1418031 (+) | 471 | WP_000447038.1 | MarR family transcriptional regulator | - |
| I6L86_RS06820 (I6L86_06820) | - | 1418031..1420307 (+) | 2277 | WP_000401876.1 | ATP-binding cassette domain-containing protein | - |
| I6L86_RS06825 (I6L86_06825) | - | 1420759..1421091 (+) | 333 | WP_000656278.1 | LytTR family DNA-binding domain-containing protein | - |
| I6L86_RS06830 (I6L86_06830) | comE/blpR | 1421102..1421842 (+) | 741 | WP_001019941.1 | response regulator transcription factor | Regulator |
| I6L86_RS06835 (I6L86_06835) | - | 1422071..1423216 (+) | 1146 | WP_000209246.1 | low temperature requirement protein A | - |
| I6L86_RS06840 (I6L86_06840) | - | 1423519..1423581 (+) | 63 | Protein_1302 | conjugal transfer protein | - |
| I6L86_RS06845 (I6L86_06845) | - | 1423906..1424589 (+) | 684 | WP_000492701.1 | LexA family transcriptional regulator | - |
| I6L86_RS06850 (I6L86_06850) | - | 1424592..1426007 (+) | 1416 | WP_000219659.1 | Y-family DNA polymerase | - |
| I6L86_RS06855 (I6L86_06855) | - | 1426004..1426369 (+) | 366 | WP_000981959.1 | hypothetical protein | - |
| I6L86_RS06860 (I6L86_06860) | - | 1426359..1426649 (+) | 291 | WP_001080187.1 | DUF5960 family protein | - |
| I6L86_RS06865 (I6L86_06865) | - | 1426944..1427303 (+) | 360 | WP_000529547.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| I6L86_RS06870 (I6L86_06870) | mobC | 1427313..1427678 (+) | 366 | WP_000263039.1 | plasmid mobilization relaxosome protein MobC | - |
| I6L86_RS06875 (I6L86_06875) | - | 1427665..1429527 (+) | 1863 | WP_000261797.1 | SAG1250 family conjugative relaxase | - |
| I6L86_RS06880 (I6L86_06880) | - | 1429571..1430419 (-) | 849 | WP_000837479.1 | helix-turn-helix domain-containing protein | - |
| I6L86_RS06885 (I6L86_06885) | - | 1430772..1431413 (+) | 642 | WP_000151481.1 | ATP-binding cassette domain-containing protein | - |
| I6L86_RS06890 (I6L86_06890) | - | 1431426..1431596 (+) | 171 | WP_000711945.1 | hypothetical protein | - |
| I6L86_RS06895 (I6L86_06895) | gdhA | 1431877..1433223 (-) | 1347 | WP_000199543.1 | NADP-specific glutamate dehydrogenase | - |
| I6L86_RS06900 (I6L86_06900) | - | 1433464..1434399 (+) | 936 | WP_000255154.1 | dihydroorotate oxidase | - |
| I6L86_RS06905 (I6L86_06905) | holA | 1434433..1435470 (+) | 1038 | WP_078228374.1 | DNA polymerase III subunit delta | - |
| I6L86_RS06910 (I6L86_06910) | sodA | 1435841..1436446 (+) | 606 | WP_000974733.1 | superoxide dismutase SodA | - |
| I6L86_RS06915 (I6L86_06915) | - | 1436608..1437138 (+) | 531 | WP_001224347.1 | YutD family protein | - |
| I6L86_RS06920 (I6L86_06920) | rlmN | 1437159..1438244 (+) | 1086 | WP_000804766.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| I6L86_RS06925 (I6L86_06925) | - | 1438244..1438726 (+) | 483 | WP_000976729.1 | VanZ family protein | - |
| I6L86_RS06930 (I6L86_06930) | - | 1438728..1440269 (+) | 1542 | WP_000025380.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| I6L86_RS06935 (I6L86_06935) | - | 1440323..1441126 (-) | 804 | WP_000717398.1 | peptidylprolyl isomerase | - |
| I6L86_RS06940 (I6L86_06940) | - | 1441431..1441655 (-) | 225 | WP_001041099.1 | helix-turn-helix transcriptional regulator | - |
| I6L86_RS06945 (I6L86_06945) | - | 1441658..1442236 (-) | 579 | WP_000742118.1 | hypothetical protein | - |
| I6L86_RS06950 (I6L86_06950) | - | 1442497..1442640 (-) | 144 | WP_001067872.1 | hypothetical protein | - |
| I6L86_RS06955 (I6L86_06955) | rpsP | 1442816..1443088 (+) | 273 | WP_000268760.1 | 30S ribosomal protein S16 | - |
| I6L86_RS06960 (I6L86_06960) | kphA | 1443108..1443347 (+) | 240 | WP_000379617.1 | RNA-binding protein KphA | - |
| I6L86_RS06965 (I6L86_06965) | - | 1443461..1444012 (+) | 552 | WP_004239319.1 | hypothetical protein | - |
| I6L86_RS06970 (I6L86_06970) | - | 1444120..1444908 (+) | 789 | WP_000821028.1 | alpha/beta fold hydrolase | - |
Sequence
Protein
Download Length: 245 a.a. Molecular weight: 28406.18 Da Isoelectric Point: 4.0236
>NTDB_id=580394 I6L86_RS06745 WP_000782682.1 1402703..1403440(+) (mecA) [Streptococcus mitis strain FDAARGOS 1456]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEGESKKEPYIYYILSFS
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLLNHDAVLN
LQKIG
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEGESKKEPYIYYILSFS
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLLNHDAVLN
LQKIG
Nucleotide
Download Length: 738 bp
>NTDB_id=580394 I6L86_RS06745 WP_000782682.1 1402703..1403440(+) (mecA) [Streptococcus mitis strain FDAARGOS 1456]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAGGAAGAGCAAGAGCAGGCTGAACAAGAAGGTGAAAGCAAGAAAGAGCCGTACATCTATTACATCCTTTCTTTTTCT
AAGTTAGCTGACTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTCTTGGCCCGTATGCGCGAGT
TTGCGGAAGATAGTGATATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGCTGAATCACGATGCAGTGCTCAAT
CTGCAAAAGATTGGATAA
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAGGAAGAGCAAGAGCAGGCTGAACAAGAAGGTGAAAGCAAGAAAGAGCCGTACATCTATTACATCCTTTCTTTTTCT
AAGTTAGCTGACTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTCTTGGCCCGTATGCGCGAGT
TTGCGGAAGATAGTGATATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGCTGAATCACGATGCAGTGCTCAAT
CTGCAAAAGATTGGATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| mecA | Streptococcus pneumoniae Rx1 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae D39 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae R6 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae TIGR4 |
97.143 |
100 |
0.971 |
| mecA | Streptococcus mutans UA159 |
49.187 |
100 |
0.494 |
| mecA | Streptococcus thermophilus LMD-9 |
46.586 |
100 |
0.473 |
| mecA | Streptococcus thermophilus LMG 18311 |
46.185 |
100 |
0.469 |