Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   SPN034156_RS00975 Genome accession   NC_021006
Coordinates   198829..199533 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae SPN034156     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 193829..204533
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN034156_RS00945 (SPN034156_01790) - 194010..194996 (+) 987 WP_000204733.1 L-lactate dehydrogenase -
  SPN034156_RS00950 (SPN034156_01800) - 195297..196040 (-) 744 Protein_185 ion channel -
  SPN034156_RS00955 (SPN034156_01810) - 196087..196341 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  SPN034156_RS00960 (SPN034156_01820) - 196343..196585 (-) 243 WP_000208080.1 DUF6290 family protein -
  SPN034156_RS00965 (SPN034156_01830) vicX 196676..197485 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  SPN034156_RS00970 (SPN034156_01840) micB 197487..198836 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SPN034156_RS00975 (SPN034156_01850) micA 198829..199533 (-) 705 WP_000722076.1 response regulator YycF Regulator
  SPN034156_RS00980 (SPN034156_01860) mutY 199588..200763 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  SPN034156_RS00985 (SPN034156_01870) - 201092..202762 (-) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  SPN034156_RS00990 (SPN034156_01880) coaB 202992..203681 (+) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  SPN034156_RS00995 (SPN034156_01890) coaC 203693..204244 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=57996 SPN034156_RS00975 WP_000722076.1 198829..199533(-) (micA) [Streptococcus pneumoniae SPN034156]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=57996 SPN034156_RS00975 WP_000722076.1 198829..199533(-) (micA) [Streptococcus pneumoniae SPN034156]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment