NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	MON07_RS09485	Genome accession	NZ_CP093395
Coordinates	2071911..2072582 (-)	Length	223 a.a.
NCBI ID	WP_003090494.1	Uniprot ID	A0A0H2ZC88
Organism	Pseudomonas aeruginosa strain PA1_NCHU
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2066911..2077582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MON07_RS09470 (MON07_09470)	-	2068029..2070173 (+)	2145	WP_023517725.1	methyl-accepting chemotaxis protein	-
MON07_RS09475 (MON07_09475)	-	2070178..2070486 (-)	309	WP_003097699.1	hypothetical protein	-
MON07_RS09480 (MON07_09480)	carS	2070577..2071914 (-)	1338	WP_023875208.1	two-component system sensor histidine kinase CarS	-
MON07_RS09485 (MON07_09485)	ciaR	2071911..2072582 (-)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
MON07_RS09490 (MON07_09490)	-	2072582..2072896 (-)	315	WP_003097704.1	PepSY domain-containing protein	-
MON07_RS09495 (MON07_09495)	-	2072896..2073204 (-)	309	WP_003090497.1	PepSY domain-containing protein	-
MON07_RS09500 (MON07_09500)	-	2073419..2074501 (+)	1083	WP_023875207.1	hypothetical protein	-
MON07_RS09505 (MON07_09505)	-	2074528..2075421 (+)	894	WP_003116712.1	hypothetical protein	-
MON07_RS09510 (MON07_09510)	-	2075405..2075671 (+)	267	WP_003090500.1	DUF5329 domain-containing protein	-
MON07_RS09515 (MON07_09515)	-	2075672..2076865 (-)	1194	WP_003131074.1	NnrS family protein	-
MON07_RS09520 (MON07_09520)	ppyR	2076852..2077109 (-)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 24729.20 Da Isoelectric Point: 5.8445

                                >NTDB_id=572075 MON07_RS09485 WP_003090494.1 2071911..2072582(-) (ciaR) [Pseudomonas aeruginosa strain PA1_NCHU]

MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA

RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR

YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

Download Length: 672 bp

                                >NTDB_id=572075 MON07_RS09485 WP_003090494.1 2071911..2072582(-) (ciaR) [Pseudomonas aeruginosa strain PA1_NCHU]

ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT

GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATCCTCGACCTCGGCC

TGCCCGGGCGCCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGCCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG

CGCGGTTCCTGGGCCGAACGCATCGATGGCCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA

GTTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCTGGGCTGC

GCCTGGACGAGCAGCGCCAGTGTGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC

TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA

TTCCAATGTCATCGAGGTCCACGTCAACCACTTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG

GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-216)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0H2ZC88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363

Detailed information NTG0572075