Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   KFU60_RS07465 Genome accession   NZ_CP073916
Coordinates   1547228..1549420 (-) Length   730 a.a.
NCBI ID   WP_003585566.1    Uniprot ID   A0A829GXH9
Organism   Lacticaseibacillus paracasei subsp. tolerans strain 2A     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1542228..1554420
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KFU60_RS07435 (KFU60_07435) - 1542393..1542677 (-) 285 WP_003580845.1 bacteriocin immunity protein -
  KFU60_RS07440 (KFU60_07440) - 1542871..1543167 (-) 297 WP_079322806.1 bacteriocin immunity protein -
  KFU60_RS07445 (KFU60_07445) - 1543269..1544624 (-) 1356 WP_003567335.1 threonine/serine exporter family protein -
  KFU60_RS07450 (KFU60_07450) - 1544930..1545241 (-) 312 WP_003580849.1 hypothetical protein -
  KFU60_RS07455 (KFU60_07455) - 1545314..1545664 (-) 351 WP_211772628.1 hypothetical protein -
  KFU60_RS07460 (KFU60_07460) - 1545838..1547217 (-) 1380 WP_211772629.1 bacteriocin secretion accessory protein -
  KFU60_RS07465 (KFU60_07465) comA 1547228..1549420 (-) 2193 WP_003585566.1 peptide cleavage/export ABC transporter Regulator
  KFU60_RS07470 (KFU60_07470) - 1549886..1550026 (-) 141 WP_016384130.1 hypothetical protein -
  KFU60_RS07475 (KFU60_07475) - 1550217..1551515 (+) 1299 WP_016388367.1 GHKL domain-containing protein -
  KFU60_RS07480 (KFU60_07480) - 1551520..1552326 (+) 807 WP_003567351.1 LytTR family DNA-binding domain-containing protein -
  KFU60_RS07485 (KFU60_07485) - 1552688..1552885 (-) 198 WP_016388366.1 hypothetical protein -
  KFU60_RS07490 (KFU60_07490) - 1553432..1553671 (+) 240 WP_003605974.1 hypothetical protein -
  KFU60_RS07495 (KFU60_07495) - 1553931..1554104 (-) 174 WP_032675994.1 bacteriocin -
  KFU60_RS07500 (KFU60_07500) - 1554139..1554327 (-) 189 WP_003567358.1 ComC/BlpC family leader-containing pheromone/bacteriocin -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81282.51 Da        Isoelectric Point: 7.0227

>NTDB_id=562279 KFU60_RS07465 WP_003585566.1 1547228..1549420(-) (comA) [Lacticaseibacillus paracasei subsp. tolerans strain 2A]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPILARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=562279 KFU60_RS07465 WP_003585566.1 1547228..1549420(-) (comA) [Lacticaseibacillus paracasei subsp. tolerans strain 2A]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGCTGGCGAAGA
CAGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCGGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATACTAGCGCGACAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTTGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGCCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACAATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATATTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCTATCAACGTGACCGATGTGTCTTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAGCAAATCAATCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGAAAAATCACATTTAATGGTGTTCCAATC
AGTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACGATTATTTTTGTCGCACACCGGCTCACCATAG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(510-662)

Peptidase C39 family (Peptidase_C39)

(16-152)

ABC transporter transmembrane region (ABC_membrane)

(180-448)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A829GXH9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

59.053

98.356

0.581
  comA Streptococcus pneumoniae Rx1

58.496

98.356

0.575
  comA Streptococcus pneumoniae D39

58.496

98.356

0.575
  comA Streptococcus pneumoniae R6

58.496

98.356

0.575
  comA Streptococcus mitis SK321

58.357

98.356

0.574
  comA Streptococcus pneumoniae TIGR4

58.078

98.356

0.571
  comA Streptococcus gordonii str. Challis substr. CH1

57.103

98.356

0.562
  comA/nlmT Streptococcus mutans UA159

54.986

98.904

0.544