Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   J9538_RS11525 Genome accession   NZ_CP072891
Coordinates   2471751..2473037 (+) Length   428 a.a.
NCBI ID   WP_088774953.1    Uniprot ID   -
Organism   Enterococcus hirae strain F104     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2442645..2471298 2471751..2473037 flank 453


Gene organization within MGE regions


Location: 2442645..2473037
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J9538_RS11400 (J9538_11400) - 2442645..2444588 (-) 1944 WP_088775427.1 transcription antiterminator -
  J9538_RS11405 (J9538_11405) - 2444756..2445709 (-) 954 WP_060799069.1 IS30 family transposase -
  J9538_RS11410 (J9538_11410) - 2445979..2447271 (-) 1293 WP_104843889.1 guanosine 5'-monophosphate oxidoreductase -
  J9538_RS11415 (J9538_11415) - 2447246..2449018 (-) 1773 WP_002334628.1 McrB family protein -
  J9538_RS11420 (J9538_11420) - 2449133..2452282 (-) 3150 WP_218210594.1 type I restriction endonuclease subunit R -
  J9538_RS11425 (J9538_11425) - 2452296..2453486 (-) 1191 WP_218210595.1 restriction endonuclease subunit S -
  J9538_RS11430 (J9538_11430) - 2453479..2455071 (-) 1593 WP_218210596.1 type I restriction-modification system subunit M -
  J9538_RS11435 (J9538_11435) - 2455254..2455574 (-) 321 Protein_2273 recombinase family protein -
  J9538_RS11440 (J9538_11440) - 2455601..2456554 (-) 954 WP_024265257.1 IS30 family transposase -
  J9538_RS11445 (J9538_11445) - 2456803..2457891 (-) 1089 WP_002286103.1 hypothetical protein -
  J9538_RS11450 (J9538_11450) - 2458134..2459771 (-) 1638 WP_218210597.1 recombinase family protein -
  J9538_RS11455 (J9538_11455) - 2459775..2461148 (-) 1374 WP_218210598.1 recombinase family protein -
  J9538_RS11460 (J9538_11460) - 2461164..2461403 (-) 240 WP_218210599.1 hypothetical protein -
  J9538_RS11465 (J9538_11465) - 2461834..2463240 (-) 1407 WP_218210600.1 phage/plasmid primase, P4 family -
  J9538_RS11470 (J9538_11470) - 2463233..2463604 (-) 372 WP_002390894.1 hypothetical protein -
  J9538_RS11475 (J9538_11475) - 2463780..2465159 (+) 1380 WP_002390895.1 hypothetical protein -
  J9538_RS11480 (J9538_11480) fic 2465511..2466116 (-) 606 WP_002328688.1 protein adenylyltransferase Fic -
  J9538_RS11485 (J9538_11485) - 2466718..2467608 (-) 891 WP_218210601.1 DUF4767 domain-containing protein -
  J9538_RS11490 (J9538_11490) - 2467683..2467979 (-) 297 WP_002336120.1 hypothetical protein -
  J9538_RS11495 (J9538_11495) - 2467972..2468265 (-) 294 WP_002326407.1 Mor transcription activator family protein -
  J9538_RS11500 (J9538_11500) - 2468411..2468962 (-) 552 WP_002296259.1 DUF1643 domain-containing protein -
  J9538_RS11505 (J9538_11505) - 2469136..2469435 (-) 300 WP_002340122.1 hypothetical protein -
  J9538_RS11510 (J9538_11510) - 2469462..2469770 (-) 309 WP_218210602.1 DUF960 domain-containing protein -
  J9538_RS11515 (J9538_11515) - 2469921..2470769 (-) 849 WP_218210603.1 hypothetical protein -
  J9538_RS11520 (J9538_11520) rlmH 2470819..2471298 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  J9538_RS11525 (J9538_11525) htrA 2471751..2473037 (+) 1287 WP_088774953.1 S1C family serine protease Regulator

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44609.73 Da        Isoelectric Point: 4.7976

>NTDB_id=556687 J9538_RS11525 WP_088774953.1 2471751..2473037(+) (htrA) [Enterococcus hirae strain F104]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAVSNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=556687 J9538_RS11525 WP_088774953.1 2471751..2473037(+) (htrA) [Enterococcus hirae strain F104]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGTGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTCGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTAGAAGGGCAACAAGGATTAGAAGTTTTATTAAAAGATGGTACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTAAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)

Trypsin-like peptidase domain (Trypsin_2)

(124-269)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453