Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | J7155_RS07360 | Genome accession | NZ_CP072707 |
| Coordinates | 1532207..1533496 (-) | Length | 429 a.a. |
| NCBI ID | WP_002319485.1 | Uniprot ID | - |
| Organism | Enterococcus faecium strain VB3378 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1514887..1564395 | 1532207..1533496 | within | 0 |
Gene organization within MGE regions
Location: 1514887..1564395
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7155_RS07260 (J7155_07245) | - | 1514981..1515640 (+) | 660 | WP_002294164.1 | deoxynucleoside kinase | - |
| J7155_RS07265 (J7155_07250) | - | 1515725..1516630 (+) | 906 | WP_002294163.1 | magnesium transporter CorA family protein | - |
| J7155_RS07270 (J7155_07255) | - | 1516632..1517264 (-) | 633 | WP_002294161.1 | pentapeptide repeat-containing protein | - |
| J7155_RS07275 (J7155_07260) | infC | 1517584..1518108 (+) | 525 | WP_002293357.1 | translation initiation factor IF-3 | - |
| J7155_RS07280 (J7155_07265) | rpmI | 1518180..1518380 (+) | 201 | WP_002289309.1 | 50S ribosomal protein L35 | - |
| J7155_RS07285 (J7155_07270) | rplT | 1518433..1518792 (+) | 360 | WP_002289310.1 | 50S ribosomal protein L20 | - |
| J7155_RS07290 (J7155_07275) | - | 1519044..1520381 (+) | 1338 | WP_002289312.1 | hypothetical protein | - |
| J7155_RS07295 (J7155_07280) | - | 1520429..1522558 (+) | 2130 | WP_002302676.1 | hydantoinase/oxoprolinase family protein | - |
| J7155_RS07300 (J7155_07285) | - | 1522533..1523222 (+) | 690 | WP_002289315.1 | hypothetical protein | - |
| J7155_RS07305 (J7155_07290) | - | 1523630..1524316 (-) | 687 | WP_002289316.1 | GntR family transcriptional regulator | - |
| J7155_RS07310 (J7155_07295) | - | 1524452..1524646 (-) | 195 | WP_002315615.1 | hypothetical protein | - |
| J7155_RS07315 (J7155_07300) | - | 1524696..1525136 (-) | 441 | WP_002289317.1 | acyl-CoA thioesterase | - |
| J7155_RS07320 (J7155_07305) | - | 1525140..1525985 (-) | 846 | WP_002289318.1 | NAD(P)H-hydrate dehydratase | - |
| J7155_RS07325 (J7155_07310) | pepV | 1526134..1527552 (+) | 1419 | WP_002294157.1 | dipeptidase PepV | - |
| J7155_RS07330 (J7155_07315) | - | 1527609..1528556 (-) | 948 | WP_002289860.1 | glycosyltransferase family 2 protein | - |
| J7155_RS07335 (J7155_07320) | - | 1528779..1529129 (-) | 351 | WP_002289862.1 | PepSY domain-containing protein | - |
| J7155_RS07340 (J7155_07325) | pepA | 1529329..1530408 (+) | 1080 | WP_002294156.1 | glutamyl aminopeptidase | - |
| J7155_RS07345 (J7155_07330) | - | 1530552..1530872 (+) | 321 | WP_002287837.1 | thioredoxin family protein | - |
| J7155_RS07350 (J7155_07335) | - | 1530894..1531358 (+) | 465 | WP_002287838.1 | universal stress protein | - |
| J7155_RS07355 (J7155_07340) | ytpR | 1531563..1532168 (+) | 606 | WP_002294153.1 | YtpR family tRNA-binding protein | - |
| J7155_RS07360 (J7155_07345) | htrA | 1532207..1533496 (-) | 1290 | WP_002319485.1 | trypsin-like peptidase domain-containing protein | Regulator |
| J7155_RS07365 (J7155_07350) | rlmH | 1533924..1534403 (+) | 480 | WP_002345011.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| J7155_RS07370 (J7155_07355) | - | 1534756..1535070 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| J7155_RS07375 (J7155_07360) | - | 1535086..1535472 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| J7155_RS07380 (J7155_07365) | - | 1535501..1536886 (+) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| J7155_RS07385 (J7155_07370) | - | 1536889..1537042 (+) | 154 | Protein_1425 | conjugal transfer protein | - |
| J7155_RS07390 (J7155_07375) | mobT | 1537065..1538270 (+) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| J7155_RS07395 (J7155_07380) | ltrA | 1539054..1540964 (+) | 1911 | WP_002286940.1 | group II intron reverse transcriptase/maturase | - |
| J7155_RS07400 (J7155_07385) | - | 1541068..1541292 (+) | 225 | WP_032509114.1 | hypothetical protein | - |
| J7155_RS07405 (J7155_07390) | - | 1541409..1541906 (+) | 498 | WP_002345010.1 | antirestriction protein ArdA | - |
| J7155_RS07410 (J7155_07395) | - | 1541993..1542385 (+) | 393 | WP_002345009.1 | conjugal transfer protein | - |
| J7155_RS07415 (J7155_07400) | - | 1542369..1544816 (+) | 2448 | WP_000331148.1 | ATP-binding protein | - |
| J7155_RS07420 (J7155_07405) | - | 1544819..1547002 (+) | 2184 | WP_002345008.1 | membrane protein | - |
| J7155_RS07425 (J7155_07410) | - | 1546999..1548000 (+) | 1002 | WP_002345007.1 | bifunctional lysozyme/C40 family peptidase | - |
| J7155_RS07430 (J7155_07415) | - | 1548015..1548929 (+) | 915 | WP_002345006.1 | conjugal transfer protein | - |
| J7155_RS07435 (J7155_07420) | - | 1549174..1549290 (+) | 117 | WP_001814923.1 | tetracycline resistance determinant leader peptide | - |
| J7155_RS07440 (J7155_07425) | tet(M) | 1549306..1551225 (+) | 1920 | WP_002345005.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| J7155_RS07445 (J7155_07430) | tet(L) | 1551323..1552696 (+) | 1374 | WP_002345004.1 | tetracycline efflux MFS transporter Tet(L) | - |
| J7155_RS07450 (J7155_07435) | mobV | 1553260..1554522 (+) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| J7155_RS07455 (J7155_07440) | - | 1554767..1555654 (+) | 888 | WP_085844421.1 | protein rep | - |
| J7155_RS07460 (J7155_07445) | - | 1555677..1556357 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| J7155_RS07465 (J7155_07450) | - | 1557109..1557843 (-) | 735 | WP_002345002.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(T) | - |
| J7155_RS07470 (J7155_07455) | ermCL | 1557903..1557962 (-) | 60 | WP_002503927.1 | 23S rRNA methylase leader peptide ErmCL | - |
| J7155_RS07475 (J7155_07460) | - | 1558064..1558744 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| J7155_RS07480 | - | 1558829..1559068 (+) | 240 | WP_002312623.1 | hypothetical protein | - |
| J7155_RS07485 (J7155_07465) | - | 1559084..1560457 (+) | 1374 | WP_002312624.1 | recombinase family protein | - |
| J7155_RS07490 (J7155_07470) | - | 1560461..1562095 (+) | 1635 | WP_002312625.1 | recombinase family protein | - |
| J7155_RS07495 (J7155_07475) | - | 1562258..1562464 (+) | 207 | WP_010706118.1 | hypothetical protein | - |
| J7155_RS07500 (J7155_07480) | - | 1562533..1563695 (+) | 1163 | WP_087043335.1 | IS3 family transposase | - |
Sequence
Protein
Download Length: 429 a.a. Molecular weight: 44898.89 Da Isoelectric Point: 4.5419
>NTDB_id=555250 J7155_RS07360 WP_002319485.1 1532207..1533496(-) (htrA) [Enterococcus faecium strain VB3378]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
Nucleotide
Download Length: 1290 bp
>NTDB_id=555250 J7155_RS07360 WP_002319485.1 1532207..1533496(-) (htrA) [Enterococcus faecium strain VB3378]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
54.569 |
91.841 |
0.501 |
| htrA | Streptococcus mutans UA159 |
59.887 |
82.517 |
0.494 |
| htrA | Streptococcus mitis NCTC 12261 |
52.778 |
92.308 |
0.487 |
| htrA | Streptococcus pneumoniae TIGR4 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae Rx1 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae D39 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae R6 |
59.05 |
78.555 |
0.464 |