Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   J7U22_RS08010 Genome accession   NZ_CP072428
Coordinates   1549224..1549973 (-) Length   249 a.a.
NCBI ID   WP_011225365.1    Uniprot ID   Q5M699
Organism   Streptococcus thermophilus strain S24749     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1544224..1554973
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J7U22_RS07990 (J7U22_07955) - 1544547..1545779 (-) 1233 WP_220016546.1 cysteine desulfurase -
  J7U22_RS07995 (J7U22_07960) sufD 1545833..1547095 (-) 1263 WP_372429528.1 Fe-S cluster assembly protein SufD -
  J7U22_RS08000 (J7U22_07965) sufC 1547132..1547902 (-) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  J7U22_RS08005 (J7U22_07970) - 1548063..1549220 (-) 1158 WP_138496642.1 glycosyltransferase family 4 protein -
  J7U22_RS08010 (J7U22_07975) mecA 1549224..1549973 (-) 750 WP_011225365.1 adaptor protein MecA Regulator
  J7U22_RS08015 (J7U22_07980) - 1550257..1550454 (+) 198 WP_224103664.1 DUF3021 family protein -
  J7U22_RS08020 (J7U22_07985) - 1550599..1551453 (-) 855 WP_014607892.1 undecaprenyl-diphosphate phosphatase -
  J7U22_RS08025 (J7U22_07990) - 1551656..1553206 (+) 1551 WP_014607891.1 ABC transporter substrate-binding protein/permease -
  J7U22_RS08030 (J7U22_07995) - 1553206..1553946 (+) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  J7U22_RS08035 (J7U22_08000) - 1554227..1554397 (-) 171 WP_023909348.1 hypothetical protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29157.70 Da        Isoelectric Point: 4.0659

>NTDB_id=552597 J7U22_RS08010 WP_011225365.1 1549224..1549973(-) (mecA) [Streptococcus thermophilus strain S24749]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=552597 J7U22_RS08010 WP_011225365.1 1549224..1549973(-) (mecA) [Streptococcus thermophilus strain S24749]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTTAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMG 18311

100

100

1
  mecA Streptococcus thermophilus LMD-9

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.377

97.992

0.562
  mecA Streptococcus pneumoniae Rx1

46.185

100

0.462
  mecA Streptococcus pneumoniae D39

46.185

100

0.462
  mecA Streptococcus pneumoniae R6

46.185

100

0.462
  mecA Streptococcus pneumoniae TIGR4

46.185

100

0.462