NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	J1N58_RS01265	Genome accession	NZ_CP071697
Coordinates	250645..251385 (+)	Length	246 a.a.
NCBI ID	WP_024376264.1	Uniprot ID	A0A2I5KS06
Organism	Streptococcus suis strain 1112S
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 245645..256385

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J1N58_RS01240 (J1N58_01240)	-	247415..248728 (+)	1314	Protein_213	IS1182 family transposase	-
J1N58_RS11720	-	248876..249274 (-)	399	WP_029180393.1	hypothetical protein	-
J1N58_RS01250 (J1N58_01250)	-	249500..249727 (+)	228	WP_024376261.1	hypothetical protein	-
J1N58_RS01255 (J1N58_01255)	-	249708..250013 (+)	306	WP_044672279.1	hypothetical protein	-
J1N58_RS01260 (J1N58_01260)	-	250304..250645 (+)	342	WP_024378069.1	LytTR family DNA-binding domain-containing protein	-
J1N58_RS01265 (J1N58_01265)	comE/blpR	250645..251385 (+)	741	WP_024376264.1	response regulator transcription factor	Regulator
J1N58_RS01270 (J1N58_01270)	-	251395..252726 (+)	1332	WP_099780237.1	GHKL domain-containing protein	-
J1N58_RS01275 (J1N58_01275)	-	252924..253073 (-)	150	WP_079267743.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
J1N58_RS01280 (J1N58_01280)	-	253171..254532 (-)	1362	WP_024378067.1	bacteriocin secretion accessory protein	-

Sequence

Protein

Download Length: 246 a.a. Molecular weight: 28757.89 Da Isoelectric Point: 7.0265

                                >NTDB_id=547034 J1N58_RS01265 WP_024376264.1 250645..251385(+) (comE/blpR) [Streptococcus suis strain 1112S]

MNVFVLEDDFAQQSRIESIVGSLMERHHIQTKKFEVFGKPDQLIRAVEEKGAHQLFFLDIEIRADDKKGLEVAQQIRDID

PFAIIVFVTTHSEYMPLAFRYQVSALDFIDKELAPAEFEARIETALLYANGKNSRTVAEDSFYYKSRYAQVQVPFADILY

IETSPHPHRVILHTEKDRLEFTGNLADILKQEKRLLQCHRSYLVNPNNVVKVDRQMKVLYFRNGSNCYVARNRMELVHNA

IRDLHR

Nucleotide

Download Length: 741 bp

                                >NTDB_id=547034 J1N58_RS01265 WP_024376264.1 250645..251385(+) (comE/blpR) [Streptococcus suis strain 1112S]

ATGAATGTATTTGTTTTAGAAGATGATTTTGCCCAACAGTCACGGATTGAGTCAATCGTTGGTAGTTTAATGGAGCGACA

CCACATTCAGACTAAGAAGTTTGAAGTTTTTGGGAAACCAGACCAGTTGATTCGGGCAGTAGAGGAAAAAGGAGCTCATC

AACTCTTTTTCTTGGACATTGAGATTCGAGCAGATGACAAGAAGGGGTTAGAGGTGGCTCAACAGATTCGTGATATTGAT

CCCTTTGCCATTATCGTTTTTGTTACCACTCACTCCGAGTATATGCCTCTGGCCTTTCGTTATCAGGTATCGGCTCTGGA

TTTTATTGATAAGGAGCTAGCCCCGGCCGAGTTTGAGGCACGGATTGAGACAGCTCTCCTTTATGCTAATGGGAAAAATA

GTCGGACGGTGGCAGAGGATTCCTTCTATTACAAGTCGCGTTATGCCCAGGTCCAAGTTCCCTTTGCGGATATTCTCTAT

ATCGAAACCTCTCCTCATCCCCATCGGGTTATTCTGCATACGGAGAAGGATCGCTTAGAGTTTACAGGGAATTTGGCAGA

TATTTTGAAACAAGAAAAAAGACTGCTCCAGTGTCATCGCTCTTACTTGGTCAATCCCAATAATGTGGTCAAGGTTGATC

GACAGATGAAAGTTCTCTACTTCCGAAATGGTAGCAACTGCTATGTCGCTCGGAATCGAATGGAGCTAGTTCATAATGCC

ATTCGAGACTTGCATAGATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(3-122)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A2I5KS06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	52.209	100	0.528
comE/comE1	Streptococcus equinus JB1	44.215	98.374	0.435
comE/comE2	Streptococcus equinus JB1	37.705	99.187	0.374
comE/comE2	Streptococcus gordonii strain NCTC7865	37.398	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.398	100	0.374

Detailed information NTG0547034