Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JZI59_RS00145 Genome accession   NZ_CP071144
Coordinates   26610..27284 (+) Length   224 a.a.
NCBI ID   WP_012515548.1    Uniprot ID   B4U2R0
Organism   Streptococcus equi subsp. equi strain 470_008     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 21610..32284
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JZI59_RS00130 (JZI59_00130) pstB 21938..22696 (+) 759 WP_012678019.1 phosphate ABC transporter ATP-binding protein PstB -
  JZI59_RS00135 (JZI59_00135) phoU 22767..23420 (+) 654 WP_012679476.1 phosphate signaling complex protein PhoU -
  JZI59_RS00140 (JZI59_00140) - 23654..26191 (+) 2538 WP_012679477.1 M1 family metallopeptidase -
  JZI59_RS00145 (JZI59_00145) ciaR 26610..27284 (+) 675 WP_012515548.1 response regulator transcription factor Regulator
  JZI59_RS00150 (JZI59_00150) ciaH 27277..28587 (+) 1311 WP_042356911.1 HAMP domain-containing sensor histidine kinase Regulator
  JZI59_RS00155 (JZI59_00155) - 28972..29391 (+) 420 WP_012679479.1 hypothetical protein -
  JZI59_RS00160 (JZI59_00160) - 29388..30581 (+) 1194 WP_042356913.1 hypothetical protein -
  JZI59_RS00165 (JZI59_00165) - 30578..30970 (+) 393 WP_012679481.1 hypothetical protein -
  JZI59_RS00170 (JZI59_00170) - 30989..31273 (+) 285 WP_012679482.1 hypothetical protein -
  JZI59_RS00175 (JZI59_00175) rpsT 31472..31720 (-) 249 WP_012679483.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25541.52 Da        Isoelectric Point: 4.5644

>NTDB_id=543083 JZI59_RS00145 WP_012515548.1 26610..27284(+) (ciaR) [Streptococcus equi subsp. equi strain 470_008]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=543083 JZI59_RS00145 WP_012515548.1 26610..27284(+) (ciaR) [Streptococcus equi subsp. equi strain 470_008]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAAGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGACAAGAGCCTTAAATTTGGCAACCTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B4U2R0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae Rx1

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae D39

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae R6

80.543

98.661

0.795
  ciaR Streptococcus pneumoniae TIGR4

80.543

98.661

0.795
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.428

100

0.393
  covR Streptococcus salivarius strain HSISS4

35.841

100

0.362