Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   JQR77_RS07935 Genome accession   NZ_CP069275
Coordinates   1544393..1546546 (-) Length   717 a.a.
NCBI ID   WP_041827378.1    Uniprot ID   A0A811IIL9
Organism   Streptococcus thermophilus strain EG007     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1495745..1569613 1544393..1546546 within 0


Gene organization within MGE regions


Location: 1495745..1569613
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JQR77_RS07670 (JQR77_07680) - 1496636..1497187 (-) 552 WP_002946999.1 cysteine hydrolase family protein -
  JQR77_RS07675 (JQR77_07685) codY 1497250..1498035 (-) 786 WP_002951720.1 GTP-sensing pleiotropic transcriptional regulator CodY -
  JQR77_RS07680 (JQR77_07690) - 1498295..1499509 (-) 1215 WP_002951721.1 pyridoxal phosphate-dependent aminotransferase -
  JQR77_RS07685 (JQR77_07695) - 1499864..1500316 (+) 453 WP_002946987.1 universal stress protein -
  JQR77_RS07690 - 1500496..1501067 (+) 572 Protein_1469 IS30 family transposase -
  JQR77_RS07695 (JQR77_07700) - 1501139..1501312 (-) 174 WP_011681546.1 hypothetical protein -
  JQR77_RS07700 (JQR77_07705) - 1501373..1501747 (-) 375 WP_084825650.1 hypothetical protein -
  JQR77_RS07705 (JQR77_07710) pflA 1501959..1502759 (-) 801 WP_002946980.1 pyruvate formate-lyase-activating protein -
  JQR77_RS07710 (JQR77_07715) - 1502947..1503057 (-) 111 WP_014621906.1 LPXTG cell wall anchor domain-containing protein -
  JQR77_RS07715 (JQR77_07720) - 1503755..1505089 (-) 1335 WP_023909902.1 hemolysin family protein -
  JQR77_RS07720 (JQR77_07725) - 1505201..1505983 (+) 783 WP_011226459.1 ABC transporter ATP-binding protein -
  JQR77_RS07725 (JQR77_07730) - 1506605..1508671 (-) 2067 WP_011681548.1 cation:proton antiporter -
  JQR77_RS07730 (JQR77_07735) - 1508680..1508922 (-) 243 WP_011226461.1 hypothetical protein -
  JQR77_RS07735 (JQR77_07740) - 1508919..1509467 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  JQR77_RS07740 (JQR77_07745) - 1509464..1510408 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  JQR77_RS07745 (JQR77_07750) - 1510493..1511570 (-) 1078 Protein_1480 SepM family pheromone-processing serine protease -
  JQR77_RS07750 (JQR77_07755) coaD 1511548..1512045 (-) 498 WP_014621910.1 pantetheine-phosphate adenylyltransferase -
  JQR77_RS07755 (JQR77_07760) rsmD 1512079..1512678 (-) 600 Protein_1482 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  JQR77_RS07760 (JQR77_07765) trxB 1512769..1513722 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  JQR77_RS07765 (JQR77_07770) - 1513755..1513979 (-) 225 WP_002951743.1 DUF4059 family protein -
  JQR77_RS07770 (JQR77_07775) - 1514194..1514937 (-) 744 WP_011681551.1 amino acid ABC transporter ATP-binding protein -
  JQR77_RS07775 (JQR77_07780) - 1514937..1515683 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  JQR77_RS07780 (JQR77_07785) - 1516079..1516909 (-) 831 WP_084825651.1 transporter substrate-binding domain-containing protein -
  JQR77_RS07785 (JQR77_07790) - 1517369..1517602 (-) 234 WP_002947030.1 hypothetical protein -
  JQR77_RS07790 (JQR77_07795) dinB 1517900..1519003 (-) 1104 WP_014608654.1 DNA polymerase IV -
  JQR77_RS07795 (JQR77_07800) pflB 1519282..1521591 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  JQR77_RS07800 (JQR77_07805) - 1521858..1522640 (+) 783 WP_011681555.1 carbonic anhydrase -
  JQR77_RS07805 (JQR77_07810) - 1522691..1523143 (+) 453 WP_014608655.1 GNAT family N-acetyltransferase -
  JQR77_RS07810 (JQR77_07815) - 1523494..1523778 (-) 285 WP_014608656.1 restriction endonuclease subunit S -
  JQR77_RS09700 (JQR77_07820) mobV 1523824..1524332 (-) 509 Protein_1494 MobV family relaxase -
  JQR77_RS07820 (JQR77_07825) - 1524777..1525532 (-) 756 WP_011681558.1 ABC transporter permease -
  JQR77_RS07825 (JQR77_07830) - 1525529..1526179 (-) 651 WP_011681559.1 ABC transporter ATP-binding protein -
  JQR77_RS07830 (JQR77_07835) - 1526382..1527338 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  JQR77_RS07835 (JQR77_07840) - 1527338..1528093 (-) 756 WP_011681560.1 CppA family protein -
  JQR77_RS07840 (JQR77_07845) - 1528375..1528737 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  JQR77_RS07845 (JQR77_07850) gla 1528824..1529687 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  JQR77_RS07850 (JQR77_07855) - 1529808..1532075 (+) 2268 WP_011681561.1 Xaa-Pro dipeptidyl-peptidase -
  JQR77_RS07855 (JQR77_07860) - 1532155..1532535 (-) 381 WP_002951783.1 hypothetical protein -
  JQR77_RS07860 (JQR77_07865) - 1532660..1532923 (-) 264 WP_002945924.1 hypothetical protein -
  JQR77_RS07865 (JQR77_07870) - 1533245..1533541 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  JQR77_RS07870 (JQR77_07875) - 1533706..1534632 (-) 927 WP_022096485.1 thioredoxin family protein -
  JQR77_RS07875 (JQR77_07880) - 1534819..1534998 (-) 180 WP_011681564.1 hypothetical protein -
  JQR77_RS07880 (JQR77_07885) - 1535027..1535419 (-) 393 WP_003094909.1 hypothetical protein -
  JQR77_RS07885 (JQR77_07890) - 1535431..1535670 (-) 240 WP_011681565.1 Blp family class II bacteriocin -
  JQR77_RS07890 (JQR77_07895) - 1535887..1537457 (+) 1571 WP_106693466.1 IS3-like element ISSth1b family transposase -
  JQR77_RS07895 (JQR77_07900) - 1537603..1537857 (-) 255 WP_014608660.1 Blp family class II bacteriocin -
  JQR77_RS09705 - 1538108..1538509 (-) 402 WP_011226490.1 hypothetical protein -
  JQR77_RS07900 (JQR77_07905) - 1539514..1539744 (-) 231 WP_011226494.1 bacteriocin class II family protein -
  JQR77_RS07905 (JQR77_07910) - 1540100..1540300 (-) 201 WP_011681569.1 hypothetical protein -
  JQR77_RS07910 (JQR77_07915) - 1540319..1540495 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  JQR77_RS07915 (JQR77_07920) - 1540745..1541482 (+) 738 WP_011681571.1 LytR/AlgR family response regulator transcription factor -
  JQR77_RS07920 - 1542013..1542816 (+) 804 WP_223899638.1 ATP-binding protein -
  JQR77_RS07925 (JQR77_07930) - 1542834..1542995 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  JQR77_RS07930 (JQR77_07935) - 1543010..1544377 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  JQR77_RS07935 (JQR77_07940) comA/nlmT 1544393..1546546 (-) 2154 WP_041827378.1 peptide cleavage/export ABC transporter Regulator
  JQR77_RS07940 (JQR77_07945) - 1547560..1549305 (-) 1746 WP_023909918.1 ABC transporter ATP-binding protein -
  JQR77_RS07945 (JQR77_07950) - 1549298..1551055 (-) 1758 WP_023909920.1 ABC transporter ATP-binding protein -
  JQR77_RS07950 - 1551243..1551449 (-) 207 WP_011681579.1 hypothetical protein -
  JQR77_RS07955 (JQR77_07960) - 1551654..1552181 (-) 528 WP_011226503.1 VanZ family protein -
  JQR77_RS07960 (JQR77_07965) rlmN 1552183..1553352 (-) 1170 WP_011227522.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  JQR77_RS07965 (JQR77_07970) - 1553356..1554078 (-) 723 WP_011681580.1 YutD family protein -
  JQR77_RS07970 (JQR77_07975) - 1554133..1555488 (-) 1356 WP_014727679.1 bifunctional metallophosphatase/5'-nucleotidase -
  JQR77_RS07975 (JQR77_07985) - 1556336..1557679 (-) 1344 WP_014608670.1 DEAD/DEAH box helicase -
  JQR77_RS07980 (JQR77_07990) mraY 1557754..1558776 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  JQR77_RS07985 (JQR77_07995) pbp2X 1558778..1561045 (-) 2268 WP_023909922.1 penicillin-binding protein PBP2X -
  JQR77_RS07990 (JQR77_08000) ftsL 1561049..1561369 (-) 321 WP_002948801.1 cell division protein FtsL -
  JQR77_RS07995 (JQR77_08005) rsmH 1561372..1562321 (-) 950 Protein_1531 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  JQR77_RS08000 (JQR77_08010) - 1562486..1563220 (-) 735 WP_224103476.1 hypothetical protein -
  JQR77_RS08005 (JQR77_08020) - 1563546..1563809 (+) 264 WP_162877224.1 hypothetical protein -
  JQR77_RS08010 (JQR77_08025) - 1564115..1564471 (-) 357 WP_023909925.1 DUF805 domain-containing protein -
  JQR77_RS08015 (JQR77_08030) - 1564820..1564960 (-) 141 WP_011681589.1 hypothetical protein -
  JQR77_RS08020 (JQR77_08035) - 1565320..1566570 (-) 1251 WP_014608675.1 glutamate-5-semialdehyde dehydrogenase -
  JQR77_RS08025 (JQR77_08040) proB 1566572..1567375 (-) 804 WP_014608676.1 glutamate 5-kinase -
  JQR77_RS08030 (JQR77_08045) - 1567496..1569085 (-) 1590 WP_014608677.1 ABC transporter permease -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80644.44 Da        Isoelectric Point: 6.8843

>NTDB_id=533224 JQR77_RS07935 WP_041827378.1 1544393..1546546(-) (comA/nlmT) [Streptococcus thermophilus strain EG007]
MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRFTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=533224 JQR77_RS07935 WP_041827378.1 1544393..1546546(-) (comA/nlmT) [Streptococcus thermophilus strain EG007]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGACATGAGGGATTGTGGAGTTGCTGCCTTGGCATCAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTTACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTCTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTATTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCACGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTAATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A811IIL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.787

99.582

0.675
  comA Streptococcus mitis NCTC 12261

66.104

99.163

0.656
  comA Streptococcus pneumoniae Rx1

65.682

99.163

0.651
  comA Streptococcus pneumoniae D39

65.682

99.163

0.651
  comA Streptococcus pneumoniae R6

65.682

99.163

0.651
  comA Streptococcus mitis SK321

65.401

99.163

0.649
  comA Streptococcus pneumoniae TIGR4

65.26

99.163

0.647
  comA Streptococcus gordonii str. Challis substr. CH1

64.006

99.582

0.637