NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	JOA01_RS04500	Genome accession	NZ_CP069079
Coordinates	877551..878222 (+)	Length	223 a.a.
NCBI ID	WP_130555646.1	Uniprot ID	A0A4Q8KZI7
Organism	Streptococcus parasuis strain BS26
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 872551..883222

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JOA01_RS04470 (JOA01_04475)	-	873165..874421 (-)	1257	WP_217375049.1	ISL3 family transposase	-
JOA01_RS10145	-	874756..875414 (-)	659	Protein_852	transposase	-
JOA01_RS10150	-	875521..876261 (-)	741	Protein_853	transposase	-
JOA01_RS04480 (JOA01_04485)	-	876215..876421 (-)	207	WP_105108462.1	hypothetical protein	-
JOA01_RS04485 (JOA01_04490)	tnpB	876475..876825 (-)	351	WP_217375050.1	IS66 family insertion sequence element accessory protein TnpB	-
JOA01_RS04490 (JOA01_04495)	-	876806..876991 (-)	186	WP_217375051.1	hypothetical protein	-
JOA01_RS04495 (JOA01_04500)	-	877188..877418 (+)	231	WP_217375052.1	hypothetical protein	-
JOA01_RS04500 (JOA01_04505)	ciaR	877551..878222 (+)	672	WP_130555646.1	response regulator transcription factor	Regulator
JOA01_RS04505 (JOA01_04510)	ciaH	878215..879588 (+)	1374	WP_217375053.1	cell wall metabolism sensor histidine kinase WalK	Regulator
JOA01_RS04510 (JOA01_04515)	-	879676..880893 (+)	1218	WP_217375054.1	transglutaminase domain-containing protein	-
JOA01_RS04515 (JOA01_04520)	rpsT	880927..881175 (-)	249	WP_217375055.1	30S ribosomal protein S20	-
JOA01_RS04520 (JOA01_04525)	coaA	881234..882154 (-)	921	WP_217375056.1	type I pantothenate kinase	-
JOA01_RS04525 (JOA01_04530)	-	882230..882820 (+)	591	WP_217375057.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25212.80 Da Isoelectric Point: 4.2408

                                >NTDB_id=532170 JOA01_RS04500 WP_130555646.1 877551..878222(+) (ciaR) [Streptococcus parasuis strain BS26]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPDKDGFQVLRELREKGVSTPVLITTA

KEGLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNTTTVNGQEVELLGKEFDLLVY

FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTAFGENLQTLRSVGYILKNV

Nucleotide

Download Length: 672 bp

                                >NTDB_id=532170 JOA01_RS04500 WP_130555646.1 877551..878222(+) (ciaR) [Streptococcus parasuis strain BS26]

ATGATTAAGATACTGTTGGTAGAAGACGATTTAAGCCTTTCTAATTCAGTCTTTGATTTTTTAGATGATTTTGCAGACGT

TATGCAAGTTTTTGATGGTGAAGAAGGTATTTACGAAGCGGAAACAGGGGTTTATGATTTAATTCTTTTAGATTTAATGT

TACCTGATAAAGATGGTTTTCAAGTATTAAGAGAATTGCGTGAAAAAGGGGTCTCAACTCCTGTTCTGATTACGACAGCC

AAGGAAGGCCTAGAGGATAAAGGACATGGGTTTGAATTGGGTGCAGATGACTATCTCACAAAACCATTCTATTTAGAAGA

ACTCAAAATGCGTATTCAAGCCTTGTTAAAACGAGCAGGGAAGTTCAATGAAAATACTCTAACGTACGGAGATGTTACTG

TCGACTTATCTACAAATACTACGACAGTCAATGGTCAAGAAGTAGAATTGTTAGGGAAAGAATTCGACTTGTTGGTATAT

TTCTTACAGAACCAGAATGTGATTTTACCTAAAACACAGATTTTTGATCGTATTTGGGGATTTGATAGTGATACAACCAT

TTCAGTTGTTGAAGTTTACGTATCGAAAGTAAGGAAAAAATTGAAAGGAACTGCATTTGGAGAAAATCTTCAAACTCTTC

GTAGTGTCGGTTACATTTTGAAAAATGTCTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4Q8KZI7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	88.341	100	0.883
ciaR	Streptococcus pneumoniae Rx1	87.892	100	0.879
ciaR	Streptococcus pneumoniae D39	87.892	100	0.879
ciaR	Streptococcus pneumoniae R6	87.892	100	0.879
ciaR	Streptococcus pneumoniae TIGR4	87.892	100	0.879
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.381

Detailed information NTG0532170