Detailed information NTG0530499

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: LLUC073_RS11845
• Genome accession: NZ_CP068698
• Coordinates: 2286401..2287624 (+)
• Length: 407 a.a.
• NCBI ID: WP_021211225.1
• Uniprot ID: A0A896TDA0
• Organism: Lactococcus cremoris strain UC073
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2287716..2288606	2286401..2287624	flank	92

Gene organization within MGE regions

Location: 2286401..2288606

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC073_RS11845 (LLUC073_11575)	htrA	2286401..2287624 (+)	1224	WP_021211225.1	S1C family serine protease	Regulator
LLUC073_RS11850 (LLUC073_11580)	-	2287716..2288606 (+)	891	WP_011676782.1	IS982-like element IS982B family transposase	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 41496.98 Da
• Isoelectric Point: 5.7726

>NTDB_id=530499 LLUC073_RS11845 WP_021211225.1 2286401..2287624(+) (htrA) [Lactococcus cremoris strain UC073]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSALET
NSSSSSN

Nucleotide

• Length: 1224 bp

>NTDB_id=530499 LLUC073_RS11845 WP_021211225.1 2286401..2287624(+) (htrA) [Lactococcus cremoris strain UC073]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACAACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTCACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACGGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTATAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCTGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCGGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACCGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGAGTGGTTGTCTACTCTGTTCAAGCGGGTCTTCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTTAAACTCTCTAAATCAACAAGCGCTTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (237-395)

• Trypsin-like peptidase domain (Trypsin_2) (107-252)

• PDZ domain (PDZ_2) (295-391)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	54.872	95.823	0.526
htrA	Streptococcus mitis NCTC 12261	55.614	94.103	0.523
htrA	Streptococcus pneumoniae Rx1	57.849	84.521	0.489
htrA	Streptococcus pneumoniae D39	57.849	84.521	0.489
htrA	Streptococcus pneumoniae R6	57.849	84.521	0.489
htrA	Streptococcus pneumoniae TIGR4	57.849	84.521	0.489
htrA	Streptococcus mutans UA159	53.117	90.663	0.482