Detailed information NTG0529911

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: K8B71_RS12815
• Genome accession: NZ_CP082823
• Coordinates: 2651063..2651734 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain SCAID TST-2021 (7/157)
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2646063..2656734

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K8B71_RS12780 (K8B71_12780)	ppyR	2646536..2646793 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
K8B71_RS12785 (K8B71_12785)	-	2646780..2647973 (+)	1194	WP_003131074.1	NnrS family protein	-
K8B71_RS12790 (K8B71_12790)	-	2647974..2648240 (-)	267	WP_003090500.1	DUF5329 domain-containing protein	-
K8B71_RS12795 (K8B71_12795)	-	2648224..2649117 (-)	894	WP_003131077.1	hypothetical protein	-
K8B71_RS12800 (K8B71_12800)	-	2649144..2650226 (-)	1083	WP_003131078.1	hypothetical protein	-
K8B71_RS12805 (K8B71_12805)	-	2650441..2650749 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
K8B71_RS12810 (K8B71_12810)	-	2650749..2651063 (+)	315	WP_003131079.1	PepSY domain-containing protein	-
K8B71_RS12815 (K8B71_12815)	ciaR	2651063..2651734 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
K8B71_RS12820 (K8B71_12820)	carS	2651731..2653068 (+)	1338	WP_003090493.1	two-component system sensor histidine kinase CarS	-
K8B71_RS12825 (K8B71_12825)	-	2653159..2653458 (+)	300	WP_003131081.1	hypothetical protein	-
K8B71_RS34880	-	2653463..2653999 (-)	537	Protein_2542	methyl-accepting chemotaxis protein	-
K8B71_RS34885	-	2654321..2655607 (-)	1287	Protein_2543	HAMP domain-containing protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=529911 K8B71_RS12815 WP_003090494.1 2651063..2651734(+) (ciaR) [Pseudomonas aeruginosa strain SCAID TST-2021 (7/157)]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=529911 K8B71_RS12815 WP_003090494.1 2651063..2651734(+) (ciaR) [Pseudomonas aeruginosa strain SCAID TST-2021 (7/157)]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGCCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GCTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGT
TATTTCATGCTGCACCCCGGTCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAAACCGAACGCGA
TTCCAATGTCATCGAGGTCCACGTCAACCACCTGCGACGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363