Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   I6J12_RS00805 Genome accession   NZ_CP068060
Coordinates   159852..160604 (+) Length   250 a.a.
NCBI ID   WP_003036395.1    Uniprot ID   I0SDH0
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 154852..165604
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS00790 (I6J12_00790) - 155253..156818 (-) 1566 WP_003036450.1 ABC transporter substrate-binding protein/permease -
  I6J12_RS00795 (I6J12_00795) - 156945..158819 (+) 1875 WP_003036355.1 DUF2207 domain-containing protein -
  I6J12_RS00800 (I6J12_00800) - 158886..159728 (+) 843 WP_003036361.1 undecaprenyl-diphosphate phosphatase -
  I6J12_RS00805 (I6J12_00805) mecA 159852..160604 (+) 753 WP_003036395.1 adaptor protein MecA Regulator
  I6J12_RS00810 (I6J12_00810) - 160595..161761 (+) 1167 WP_003036405.1 glycosyltransferase family 4 protein -
  I6J12_RS00815 (I6J12_00815) sufC 161852..162622 (+) 771 WP_025271948.1 Fe-S cluster assembly ATPase SufC -
  I6J12_RS00820 (I6J12_00820) sufD 162662..163924 (+) 1263 WP_003036420.1 Fe-S cluster assembly protein SufD -
  I6J12_RS00825 (I6J12_00825) - 163940..165172 (+) 1233 WP_003036376.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 28987.89 Da        Isoelectric Point: 4.1612

>NTDB_id=526776 I6J12_RS00805 WP_003036395.1 159852..160604(+) (mecA) [Streptococcus anginosus strain FDAARGOS_1155]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDMEAVRSLETAEADDNTSTSDMESEENSDELTQKYIYYIL
KFSSLKEAIVFSKTVDYAVNTSELYKMDDRYYLTILVDIEGRPKRYPAWLLALMREHAEDTDVTRAVLQEHGYLLLVNEA
VASLKKVKCL

Nucleotide


Download         Length: 753 bp        

>NTDB_id=526776 I6J12_RS00805 WP_003036395.1 159852..160604(+) (mecA) [Streptococcus anginosus strain FDAARGOS_1155]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAAATCACAATAAAATTAGAGGATTTAGAGGAACGTGGGATGGAAAT
GGCAGATTTTCTCGTTCCACAAGAAAAGACAGAGGAATTTTTCTATGCGATTTTAGATGAGTTGGAAATGCCAGAGAGCT
TTTTAGATAGTGGCATGCTCAGTTTTCGTGTGACACCAAAGCCCGACCGATTGGATGTCTTTGTCACCAAGTCTAAGATT
GATAAGAATTTGAACTTCGATGATTTGGCAGATTTGCCAGATGTAGAAGAGTTGTCTCAAATGTCTCCTGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGTAAAGACGATATGGAGGCTGTTCGTTCTTTGGAAACGGCGGAAGCAG
ACGATAACACAAGCACTTCTGATATGGAGTCAGAGGAAAATAGTGACGAACTAACGCAGAAATATATTTATTACATTTTG
AAATTTTCCAGCCTGAAAGAAGCAATTGTTTTTTCTAAGACAGTAGATTATGCTGTCAATACTTCGGAGTTGTACAAAAT
GGACGACCGCTATTATTTGACAATCTTGGTTGATATTGAAGGGCGTCCAAAGCGTTATCCAGCTTGGCTCCTGGCTTTGA
TGCGTGAACATGCAGAAGATACGGATGTGACAAGAGCTGTTTTGCAAGAGCACGGTTACTTATTGCTTGTCAACGAGGCG
GTTGCCAGTCTTAAAAAGGTTAAATGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SDH0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

66.397

98.8

0.656
  mecA Streptococcus pneumoniae D39

66.397

98.8

0.656
  mecA Streptococcus pneumoniae R6

66.397

98.8

0.656
  mecA Streptococcus pneumoniae TIGR4

65.992

98.8

0.652
  mecA Streptococcus mutans UA159

50.201

99.6

0.5
  mecA Streptococcus thermophilus LMD-9

45.49

100

0.464
  mecA Streptococcus thermophilus LMG 18311

45.098

100

0.46