Detailed information NTG0526143

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: JJN14_RS02070
• Genome accession: NZ_CP067992
• Coordinates: 412701..413438 (+)
• Length: 245 a.a.
• NCBI ID: WP_201058769.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain S022-V7-A3
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 407701..418438

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JJN14_RS02040 (JJN14_02040)	-	409138..409425 (-)	288	WP_000777754.1	hypothetical protein	-
JJN14_RS02045 (JJN14_02045)	-	409435..409845 (-)	411	WP_201058766.1	HIT family protein	-
JJN14_RS02050 (JJN14_02050)	pptA	409913..410644 (+)	732	WP_000889954.1	ABC transporter ATP-binding protein	Regulator
JJN14_RS02055 (JJN14_02055)	-	410641..411690 (+)	1050	WP_201058767.1	ABC transporter permease	-
JJN14_RS02060 (JJN14_02060)	-	411752..412081 (-)	330	WP_201058768.1	helicase BlpT	-
JJN14_RS02065 (JJN14_02065)	-	412358..412696 (+)	339	WP_150922867.1	LytTR family DNA-binding domain-containing protein	-
JJN14_RS02070 (JJN14_02070)	comE/blpR	412701..413438 (+)	738	WP_201058769.1	response regulator transcription factor	Regulator
JJN14_RS02075 (JJN14_02075)	-	413452..414801 (+)	1350	WP_201058770.1	sensor histidine kinase	-
JJN14_RS02080 (JJN14_02080)	-	414870..415226 (+)	357	WP_033679716.1	hypothetical protein	-
JJN14_RS02085 (JJN14_02085)	-	415928..416092 (+)	165	WP_201058771.1	hypothetical protein	-
JJN14_RS02090 (JJN14_02090)	-	416089..416493 (+)	405	WP_201058772.1	immunity protein	-
JJN14_RS02095 (JJN14_02095)	blpZ	416539..416787 (+)	249	WP_000276515.1	immunity protein BlpZ	-
JJN14_RS02100 (JJN14_02100)	-	416818..417429 (+)	612	WP_201058773.1	CPBP family intramembrane glutamic endopeptidase	-
JJN14_RS02105 (JJN14_02105)	ccrZ	417591..418385 (+)	795	WP_000362999.1	cell cycle regulator CcrZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28818.98 Da
• Isoelectric Point: 6.3078

>NTDB_id=526143 JJN14_RS02070 WP_201058769.1 412701..413438(+) (comE/blpR) [Streptococcus mitis strain S022-V7-A3]
MRIFVLEDDFSQQARIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRERD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
IETSPRPHRVILYTKTDRLEFTASLEEVLKQEPRFLQCHRSFLVNPTNVVRLDKKEKLLFFPNGGSCLIARYKVREVSEA
ITNLH

Nucleotide

• Length: 738 bp

>NTDB_id=526143 JJN14_RS02070 WP_201058769.1 412701..413438(+) (comE/blpR) [Streptococcus mitis strain S022-V7-A3]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAAGCTAGAATTGAAACGACCATTGAGAAACTTTTGAAAGAACA
TCATATCACTCCCAGCTCTTTTGAGGTCTTTGGCAAGCCAGATCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCGCATC
AGCTTTTCTTTTTGGATATTGAGATTCGAAACGAAGAGATGAAGGGGCTAGAGGTGGCTAGAAAGATTCGGGAACGGGAC
CCCTATGCTCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCTTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCCTTTAAAGAGGTTTACTAT
ATCGAAACGTCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTGGAATTTACGGCGAGTTTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTTTCTTGCAGTGTCATCGCTCTTTTCTAGTCAATCCAACTAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCTAATGGTGGAAGCTGTCTCATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATCACTAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.878	100	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38
comE	Streptococcus infantis strain Atu-4	37.398	100	0.376