Detailed information NTG0521510

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: JCP86_RS01215
• Genome accession: NZ_CP066659
• Coordinates: 248234..249523 (-)
• Length: 429 a.a.
• NCBI ID: WP_002290101.1
• Uniprot ID: A0A828ZUK2
• Organism: Enterococcus faecium strain Dallas 155
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	246026..247318	248234..249523	flank	916

Gene organization within MGE regions

Location: 246026..249523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JCP86_RS01205 (JCP86_01205)	-	246026..247318 (-)	1293	WP_000122610.1	ISL3-like element IS1251 family transposase	-
JCP86_RS01210 (JCP86_01210)	ytpR	247590..248195 (+)	606	WP_002313997.1	YtpR family tRNA-binding protein	-
JCP86_RS01215 (JCP86_01215)	htrA	248234..249523 (-)	1290	WP_002290101.1	S1C family serine protease	Regulator

Sequence

Protein

• Length: 429 a.a.
• Molecular weight: 44916.93 Da
• Isoelectric Point: 4.5419

>NTDB_id=521510 JCP86_RS01215 WP_002290101.1 248234..249523(-) (htrA) [Enterococcus faecium strain Dallas 155]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide

• Length: 1290 bp

>NTDB_id=521510 JCP86_RS01215 WP_002290101.1 248234..249523(-) (htrA) [Enterococcus faecium strain Dallas 155]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (10-417)

• Trypsin-like peptidase domain (Trypsin_2) (127-272)

• PDZ domain (PDZ_2) (317-414)

3D structure

• AlphaFold DB: A0A828ZUK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	54.569	91.841	0.501
htrA	Streptococcus mutans UA159	60.169	82.517	0.496
htrA	Streptococcus mitis NCTC 12261	52.778	92.308	0.487
htrA	Streptococcus pneumoniae TIGR4	59.05	78.555	0.464
htrA	Streptococcus pneumoniae Rx1	59.05	78.555	0.464
htrA	Streptococcus pneumoniae D39	59.05	78.555	0.464
htrA	Streptococcus pneumoniae R6	59.05	78.555	0.464