Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   JF649_RS02280 Genome accession   NZ_CP066541
Coordinates   435175..435885 (+) Length   236 a.a.
NCBI ID   WP_129322120.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS270     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 430175..440885
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JF649_RS02260 (JF649_02260) - 431027..431176 (+) 150 WP_002990686.1 hypothetical protein -
  JF649_RS02265 (JF649_02265) - 431571..432719 (+) 1149 WP_053308554.1 acetyl-CoA C-acyltransferase -
  JF649_RS02270 (JF649_02270) - 432676..433923 (+) 1248 WP_014407393.1 AMP-binding protein -
  JF649_RS02275 (JF649_02275) - 433979..435013 (+) 1035 WP_194118140.1 DUF3114 domain-containing protein -
  JF649_RS02280 (JF649_02280) vicR 435175..435885 (+) 711 WP_129322120.1 response regulator YycF Regulator
  JF649_RS02285 (JF649_02285) vicK 435878..437230 (+) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  JF649_RS02290 (JF649_02290) vicX 437234..438043 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  JF649_RS02295 (JF649_02295) rnc 438486..439178 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.01 Da        Isoelectric Point: 4.9944

>NTDB_id=520685 JF649_RS02280 WP_129322120.1 435175..435885(+) (vicR) [Streptococcus pyogenes strain MGAS270]
MKKILIVDDEKPISNIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=520685 JF649_RS02280 WP_129322120.1 435175..435885(+) (vicR) [Streptococcus pyogenes strain MGAS270]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTAATATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGAACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

89.831

100

0.898
  micA Streptococcus pneumoniae Cp1015

78.632

99.153

0.78
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364