Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   IGS65_RS07825 Genome accession   NZ_CP066294
Coordinates   1570400..1570981 (+) Length   193 a.a.
NCBI ID   WP_244667083.1    Uniprot ID   -
Organism   Streptococcus mutans strain 27-3     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1551922..1585912 1570400..1570981 within 0


Gene organization within MGE regions


Location: 1551922..1585912
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGS65_RS07670 (IGS65_007670) ftsH 1551922..1553892 (+) 1971 WP_002264625.1 ATP-dependent zinc metalloprotease FtsH -
  IGS65_RS07675 (IGS65_007675) - 1554380..1555792 (+) 1413 WP_002304973.1 amino acid permease -
  IGS65_RS07785 (IGS65_007785) mreC 1562884..1563702 (+) 819 WP_002279251.1 rod shape-determining protein MreC -
  IGS65_RS07790 (IGS65_007790) mreD 1563704..1564210 (+) 507 WP_002263141.1 rod shape-determining protein MreD -
  IGS65_RS07795 (IGS65_007795) - 1564320..1565615 (+) 1296 WP_002264119.1 CHAP domain-containing protein -
  IGS65_RS07800 (IGS65_007800) - 1565740..1566708 (+) 969 WP_002263139.1 ribose-phosphate diphosphokinase -
  IGS65_RS07805 (IGS65_007805) - 1566797..1567972 (+) 1176 WP_002290809.1 pyridoxal phosphate-dependent aminotransferase -
  IGS65_RS07810 (IGS65_007810) recO 1567962..1568717 (+) 756 WP_002270782.1 DNA repair protein RecO -
  IGS65_RS07815 (IGS65_007815) plsX 1568925..1569923 (+) 999 WP_002267904.1 phosphate acyltransferase PlsX -
  IGS65_RS07820 (IGS65_007820) - 1569925..1570173 (+) 249 WP_002263135.1 acyl carrier protein -
  IGS65_RS07825 (IGS65_007825) comA 1570400..1570981 (+) 582 WP_244667083.1 ATP-binding cassette domain-containing protein Regulator
  IGS65_RS07830 (IGS65_007830) purC 1571103..1571810 (+) 708 WP_002274471.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  IGS65_RS07835 (IGS65_007835) - 1571820..1575545 (+) 3726 WP_192071998.1 phosphoribosylformylglycinamidine synthase -
  IGS65_RS07840 (IGS65_007840) - 1575568..1576188 (+) 621 WP_192071999.1 DNA alkylation repair protein -
  IGS65_RS07845 (IGS65_007845) purF 1576214..1577653 (+) 1440 WP_002263130.1 amidophosphoribosyltransferase -
  IGS65_RS07850 (IGS65_007850) purM 1577711..1578733 (+) 1023 WP_192072000.1 phosphoribosylformylglycinamidine cyclo-ligase -
  IGS65_RS07855 (IGS65_007855) purN 1578733..1579287 (+) 555 WP_002273392.1 phosphoribosylglycinamide formyltransferase -
  IGS65_RS07860 (IGS65_007860) - 1579394..1580101 (+) 708 WP_002265925.1 suppressor of fused domain protein -
  IGS65_RS07865 (IGS65_007865) purH 1580143..1581690 (+) 1548 WP_192072001.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  IGS65_RS07870 (IGS65_007870) - 1581873..1582415 (-) 543 WP_002290820.1 TetR/AcrR family transcriptional regulator -
  IGS65_RS07875 (IGS65_007875) - 1582583..1583092 (+) 510 WP_192072002.1 HXXEE domain-containing protein -
  IGS65_RS07880 (IGS65_007880) - 1583582..1584457 (+) 876 WP_192072003.1 Abi family protein -
  IGS65_RS07885 (IGS65_007885) - 1584533..1585912 (+) 1380 WP_002283797.1 Eco57I restriction-modification methylase domain-containing protein -

Sequence

Protein


Download         Length: 193 a.a.        Molecular weight: 21329.34 Da        Isoelectric Point: 4.8780

>NTDB_id=519149 IGS65_RS07825 WP_244667083.1 1570400..1570981(+) (comA) [Streptococcus mutans strain 27-3]
MVKSGSGKTTLAKILAGYYTVSSGDSFLDGEKINYSQLRQLVTYVPQQSYVFTGTILDNLLLGAEEEVTDDRLMEVCSIA
EILDDIKAMPLGFQTQISADGGLSGGQKQRLAIARALLTRQPVLIFDEATSGLDRDTEEKVIANLSKLDRTIIFIAHRGS
VSYYADRIVEIDSGEKIKDRINHRPFSFLMTTL

Nucleotide


Download         Length: 582 bp        

>NTDB_id=519149 IGS65_RS07825 WP_244667083.1 1570400..1570981(+) (comA) [Streptococcus mutans strain 27-3]
ATGGTGAAAAGTGGTTCTGGAAAGACAACTTTGGCAAAAATTCTTGCAGGTTATTATACTGTTAGTAGCGGTGACTCTTT
CTTGGATGGAGAAAAGATAAATTATTCCCAGCTGCGCCAATTAGTAACTTATGTGCCACAGCAGTCTTATGTTTTTACAG
GAACAATCTTAGATAATCTGCTTCTTGGTGCTGAAGAGGAAGTAACGGATGATCGCTTAATGGAAGTTTGTTCAATTGCT
GAAATTTTAGACGATATCAAGGCAATGCCTTTAGGTTTTCAAACACAGATTTCAGCAGACGGCGGTTTATCTGGTGGTCA
AAAACAGCGTTTAGCTATTGCACGTGCTCTCTTAACCAGACAGCCTGTGTTGATTTTTGATGAGGCAACTAGCGGTTTAG
ATCGTGATACCGAAGAAAAAGTTATTGCCAATTTATCTAAATTGGATCGCACGATTATTTTTATTGCTCACCGAGGCAGT
GTTTCTTATTATGCTGATCGAATTGTTGAGATTGACTCTGGAGAGAAAATTAAGGACAGAATAAATCATCGTCCTTTCTC
ATTTTTGATGACGACTCTTTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(3-131)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

52.174

95.337

0.497
  comA Streptococcus gordonii str. Challis substr. CH1

53.073

92.746

0.492
  comA/nlmT Streptococcus mutans UA159

49.73

95.855

0.477
  comA Streptococcus pneumoniae R6

50.556

93.264

0.472
  comA Streptococcus pneumoniae Rx1

50.556

93.264

0.472
  comA Streptococcus pneumoniae D39

50.556

93.264

0.472
  comA Streptococcus mitis SK321

49.444

93.264

0.461
  comA Streptococcus pneumoniae TIGR4

49.444

93.264

0.461