Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   IGS65_RS05500 Genome accession   NZ_CP066294
Coordinates   1125865..1127715 (-) Length   616 a.a.
NCBI ID   WP_002263039.1    Uniprot ID   A0AAX1K050
Organism   Streptococcus mutans strain 27-3     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1120865..1132715
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGS65_RS05475 (IGS65_005475) - 1121262..1121648 (-) 387 WP_002263034.1 S1 RNA-binding domain-containing protein -
  IGS65_RS05480 (IGS65_005480) - 1121632..1123047 (-) 1416 WP_168750710.1 Cof-type HAD-IIB family hydrolase -
  IGS65_RS05485 (IGS65_005485) - 1123091..1123732 (-) 642 WP_002263036.1 response regulator transcription factor -
  IGS65_RS05490 (IGS65_005490) - 1123725..1124729 (-) 1005 WP_002263037.1 sensor histidine kinase -
  IGS65_RS05495 (IGS65_005495) liaF 1124726..1125421 (-) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  IGS65_RS05500 (IGS65_005500) pknB 1125865..1127715 (-) 1851 WP_002263039.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  IGS65_RS05505 (IGS65_005505) - 1127712..1128455 (-) 744 WP_002263040.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  IGS65_RS05510 (IGS65_005510) rsmB 1128494..1129816 (-) 1323 WP_002291122.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  IGS65_RS05515 (IGS65_005515) fmt 1129797..1130732 (-) 936 WP_192072088.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66913.66 Da        Isoelectric Point: 9.4520

>NTDB_id=519130 IGS65_RS05500 WP_002263039.1 1125865..1127715(-) (pknB) [Streptococcus mutans strain 27-3]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=519130 IGS65_RS05500 WP_002263039.1 1125865..1127715(-) (pknB) [Streptococcus mutans strain 27-3]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGCATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGGATTATGCTTTTTGAAATGCTGACAGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGTAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGACTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTTAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATACTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-258)

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(438-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

100

100

1
  stkP/pknB Streptococcus salivarius strain HSISS4

62.919

96.753

0.609
  stkP Streptococcus pneumoniae TIGR4

52.381

98.864

0.518
  stkP Streptococcus pneumoniae D39

52.217

98.864

0.516
  stkP Streptococcus pneumoniae R6

52.217

98.864

0.516
  stkP Streptococcus pneumoniae Rx1

52.053

98.864

0.515