Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IGS65_RS02625 Genome accession   NZ_CP066294
Coordinates   519381..520055 (+) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans strain 27-3     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 514381..525055
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGS65_RS02605 (IGS65_002605) pstB 514633..515391 (+) 759 WP_192072240.1 phosphate ABC transporter ATP-binding protein PstB -
  IGS65_RS02610 (IGS65_002610) phoU 515423..516076 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  IGS65_RS02615 (IGS65_002615) - 516117..518666 (+) 2550 WP_002286918.1 M1 family metallopeptidase -
  IGS65_RS02620 (IGS65_002620) ciaX 519067..519330 (+) 264 WP_002281780.1 three-component system regulator CiaX -
  IGS65_RS02625 (IGS65_002625) ciaR 519381..520055 (+) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  IGS65_RS02630 (IGS65_002630) ciaH 520045..521352 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  IGS65_RS02635 (IGS65_002635) rpsT 521440..521694 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  IGS65_RS02640 (IGS65_002640) coaA 521748..522668 (-) 921 WP_002262217.1 type I pantothenate kinase -
  IGS65_RS02645 (IGS65_002645) - 522764..523360 (+) 597 WP_019314021.1 class I SAM-dependent methyltransferase -
  IGS65_RS02650 (IGS65_002650) - 523469..524746 (+) 1278 WP_192072239.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=519114 IGS65_RS02625 WP_002264509.1 519381..520055(+) (ciaR) [Streptococcus mutans strain 27-3]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=519114 IGS65_RS02625 WP_002264509.1 519381..520055(+) (ciaR) [Streptococcus mutans strain 27-3]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371