Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I8F50_RS01345 Genome accession   NZ_CP066215
Coordinates   272471..273760 (-) Length   429 a.a.
NCBI ID   WP_002304098.1    Uniprot ID   A0A7V8C7J4
Organism   Enterococcus faecium strain 18-042     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 267471..278760
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I8F50_RS01315 (I8F50_01315) - 267873..268820 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  I8F50_RS01320 (I8F50_01320) - 269043..269393 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  I8F50_RS01325 (I8F50_01325) pepA 269593..270672 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  I8F50_RS01330 (I8F50_01330) - 270816..271136 (+) 321 WP_002287837.1 thioredoxin family protein -
  I8F50_RS01335 (I8F50_01335) - 271158..271622 (+) 465 WP_002287838.1 universal stress protein -
  I8F50_RS01340 (I8F50_01340) ytpR 271827..272432 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  I8F50_RS01345 (I8F50_01345) htrA 272471..273760 (-) 1290 WP_002304098.1 S1C family serine protease Regulator
  I8F50_RS01350 (I8F50_01350) rlmH 274188..274667 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I8F50_RS01355 (I8F50_01355) - 274752..275261 (+) 510 WP_002296569.1 DUF1456 family protein -
  I8F50_RS01360 (I8F50_01360) - 275361..276011 (+) 651 WP_002296570.1 hypothetical protein -
  I8F50_RS01365 (I8F50_01365) - 276462..277400 (+) 939 WP_002291914.1 2-dehydropantoate 2-reductase -
  I8F50_RS01370 (I8F50_01370) - 277413..278465 (+) 1053 WP_002291912.1 PTS sugar transporter subunit IIC -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44885.89 Da        Isoelectric Point: 4.5419

>NTDB_id=518430 I8F50_RS01345 WP_002304098.1 272471..273760(-) (htrA) [Enterococcus faecium strain 18-042]
MDRKNVTPKMKKSKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENIKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=518430 I8F50_RS01345 WP_002304098.1 272471..273760(-) (htrA) [Enterococcus faecium strain 18-042]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAGTAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATATCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(317-414)

Peptidase family M50 (Peptidase_M50)

(9-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7V8C7J4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.269

96.27

0.513
  htrA Streptococcus mutans UA159

59.605

82.517

0.492
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464